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SZGene - Gene overview of all published SZ-association studies for TCF4    
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 Gene: TCF4  (E2-2; ITF2; SEF2; SEF2-1; SEF2-1A; SEF2-1B)  Entrez Gene
 Protein: transcription factor 4  (immunoglobulin transcription factor-2)  ProteinLink
 Chromosome: 18   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 22 October 2010
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      SZ Cases Normal Controls    
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Bowen, 2000
UK, Ireland CL  1  (detail)  206
(31%)
IIIR-41.1 + 12.9
(-)
219
(32%)
41.5 + 11.9
(-)
Negative
McInnis, 2000
Sweden CL  1  (detail)  96
(-)
U--96
(-)
-Negative
Stefansson, 2009
Denmark (Aarhus; Follow-up) CL  1  (detail)  680
(-)
M--1110
(-)
-Negative
Stefansson, 2009
Denmark (Copenhagen; Follow-up) CL  1  (detail)  513
(-)
10--1339
(-)
-Negative
Stefansson, 2009
Finland (Follow-up) CL  1  (detail)  287
(-)
IV--3987
(-)
-Positive
Stefansson, 2009
Finland (Helsinki; GWAS) CL  1  (detail)  59
(-)
IV--147
(-)
-Trend
Stefansson, 2009
Finland (Kuusamo; GWAS) CL  1  (detail)  123
(-)
IV--50
(-)
-Negative
Stefansson, 2009
Germany (Bonn; Follow-up) CL  1  (detail)  618
(-)
IV--1550
(-)
-Negative
Stefansson, 2009
Germany (Bonn; GWAS) CL  1  (detail)  483
(-)
IV--367
(-)
-Positive
Stefansson, 2009
Germany (Munich; Follow-up) CL  1  (detail)  303
(-)
IV--1625
(-)
-Trend
Stefansson, 2009
Germany (Munich; GWAS) CL  1  (detail)  574
(-)
IV--604
(-)
-Negative
Stefansson, 2009
Hungary (Follow-up) CL  1  (detail)  272
(-)
IV--227
(-)
-Negative
Stefansson, 2009
Iceland (GWAS) CL  1  (detail)  589
(-)
M--11492
(-)
-Trend
Stefansson, 2009
Italy (GWAS) CL  1  (detail)  84
(-)
10--89
(-)
-Trend
Stefansson, 2009
Netherlands-I (Follow-up) CL  1  (detail)  715
(-)
IV--3634
(-)
-Positive
Stefansson, 2009
Norway (Follow-up) CL  1  (detail)  114
(-)
M--170
(-)
-Negative
Stefansson, 2009
Russia (Follow-up) CL  1  (detail)  484
(-)
IV--491
(-)
-Negative
Stefansson, 2009
Spain (Santiago; Follow-up) CL  1  (detail)  296
(-)
IV--625
(-)
-Negative
Stefansson, 2009
Spain (Valencia; Follow-up) CL  1  (detail)  371
(-)
IV--417
(-)
-Negative
Stefansson, 2009
Sweden (Follow-up) CL  1  (detail)  255
(-)
M--293
(-)
-Positive
Stefansson, 2009
UK (England; GWAS) CL  1  (detail)  93
(-)
10--88
(-)
-Negative
Stefansson, 2009
UK (Scotland; GWAS) CL  1  (detail)  658
(-)
M--661
(-)
-Trend
Stefansson, 2009
Netherlands-II (Follow-up) CL  1  (detail)  91
(-)
IV--87
(-)
-Negative
 Asian
Li, 2010
China CL  2  (detail)  2496
(45%)
IV25.6 + 8.1
(-)
-5184
(48%)
56.2 + 12.8
(-)
Positive
 Other/Mixed
Vincent, 1999
USA CL  1  (detail)  97
(28%)
IIIR-34.2 + 8.5
(-)
97
(28%)
33.3 + 8.3
(-)
Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine SZ diagnosis ->  "IIIR"(DSM-IIIR), "IV" (DSM-IV), "9" (ICD-9), "10" (ICD-10), "M" (Mixed), "RDC" (Research Diagnostic Criteria), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
SZGene Recent Updates
SZGene Stats
Studies: 1727
Genes: 1008
Polymorphisms: 8788
Meta-analyses: 287
ALSGene
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SZGene
An up-to-date collection of all published genetic association studies.
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