SZGene

Printable version

SZGene - Gene overview of all published SZ-association studies for DBH

Gene:

DBH (DBM)

View on AlzGene View on PDGene

Protein:

dopamine beta-hydroxylase (dopamine beta-monooxygenase)

Chromosome:

9 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 19 January 2010

1. Case-Control Studies (by ethnic group)
				SZ Cases				Normal Controls
Study	Population	Source	# Polys	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result	Comment
Caucasian
Arrufat, 2000	Spain	CL	1 (detail)	47 (-)	U	-	-	74 (-)	-	Negative
Hoogendoorn, 2005	Netherlands	CL	2 (detail)	208 (-)	IV	-	-	288 (-)	-	Negative
Jonsson, 2003	Finland	CL	1 (detail)	155 (39%)	IIIR	-	42.7 + 13.4 (-)	436 (44%)	41 + 16.9 (-)	Negative
Meda, 2009	USA	CL	1 (detail)	31 (-)	IV	-	-	35 (-)	-	Negative
Meszaros, 1996	Austria	CL	2 (detail)	64 (-)	IIIR	-	-	60 (-)	-	Negative
Pal, 2009	Croatia	CL	8 (detail)	103 (42%)	10	-	43.6 + 10.6 (23-74)	131 (-)	50.3 + 7.5 (30-74)	Positive
Talkowski, 2008	USA	CL	9 (detail)	328 (-)	IV	-	-	501 (-)	-	Negative
Wei, 1996	UK	CL	1 (detail)	174 (32%)	U	-	35.3 + 10.5 (-)	72 (53%)	39.7 + 13.6 (-)	Negative
Wei, 1997	UK	CL	1 (detail)	175 (34%)	U	-	36.1 + 10.4 (-)	81 (48%)	39.7 + 13.5 (-)	Negative
Williams, 1999	UK	CL	1 (detail)	178 (30%)	IIIR	-	41 + 13.1 (-)	178 (30%)	40 + 11.9 (-)	Negative
Yamamoto, 2003	Canada	CL	2 (detail)	106 (28%)	U	-	-	120 (55%)	-	Negative
Asian
Iwata, 2003	Japan	CL	1 (detail)	51 (57%)	IV	13.5 + 1.7 (9-16)	20 + 7 (-)	148 (56%)	21 + 7 (-)	Negative
Park, 2007	Korea	CL	3 (detail)	140 (-)	IV	-	-	161 (-)	-	Negative
Other/Mixed
Srivastava, 2010	India	CL	5 (detail)	215 (48%)	IV	21.4 + 6.1 (-)	29.3 + 8.9 (-)	215 (40%)	34.6 + 12.4 (-)	Positive

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

2. Family-Based Studies (by ethnic group)
				Affecteds				Unaffecteds
Study	Population	# Polys	# Families	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result	Comment
Caucasian
Arrufat, 2000	Spain	1 (detail)	47	47 (-)	U	-	-	72 (-)	-	Negative
Meszaros, 1996	Austria	1 (detail)	34	48 (-)	IIIR	-	-	-	-	Negative
Talkowski, 2008	USA	9 (detail)	150	150 (50%)	IV	-	-	300 (50%)	-	Negative

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine SZ diagnosis -> "IIIR"(DSM-IIIR), "IV" (DSM-IV), "9" (ICD-9), "10" (ICD-10), "M" (Mixed), "RDC" (Research Diagnostic Criteria), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.


SZGene Recent Updates
SZGene Stats Studies: 1727 Genes: 1008 Polymorphisms: 8788 Meta-analyses: 287





			ALSGene
			AlzGene
			MSGene
			PDGene
			SZGene

			An up-to-date collection of all published genetic association studies.






			SRF News SRF Comments Text Size Reset Text Size Email this page







			Research Participants Collaborators