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SZGene - Gene overview of all published SZ-association studies for HTR1B    
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 Gene: HTR1B  (S12; 5-HT1B; HTR1D2; HTR1DB)  Entrez Gene
 Protein: 5-hydroxytryptamine receptor 1B  (serotonin receptor 1B)  ProteinLink
 Chromosome: 6   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 11 October 2010
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      SZ Cases Normal Controls    
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Pal, 2009
Croatia CL  5  (detail)  103
(42%)
10-436 + 106
(23-74)
131
(-)
503 + 75
(30-74)
Positive
Rujescu, 2003
Germany CO  1  (detail)  28
(-)
IV--327
(55%)
45.8 + 14.9
(19-79)
Negative
 Asian
Duan, 2005
China CL  5  (detail)  456
(45%)
IV27.8 + 7.1
(-)
43.3 + 10.1
(-)
557
(46%)
37.7 + 9.8
(-)
Negative
Hong, 2004
Taiwan PO  1  (detail)  110
(54%)
IV-37.2 + 13.3
(-)
215
(58%)
35.3 + 8
(-)
Negative
 Other/Mixed
Cordeiro, 2005
Brazil CL  1  (detail)  196
(-)
IV--143
(-)
-Negative
Huang, 2003
USA CL  1  (detail)  83
(-)
M--96
(47%)
40.9 + 15.9
(-)
Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds    
Study Population # Polys # Families # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Ambrosio, 2004
Portugal  2  (detail)  9292
(35%)
IV--184
(50%)
-Negative
 Asian
Duan, 2005
China  1  (detail)  229229
(40%)
IV28.2 + 8.5
(-)
32.3 + 9.8
(-)
458
(50%)
-Negative
 Other/Mixed
Sanders, 2001
USA (NIMH I)  6  (detail)  82-IIIR----Negative
Sanders, 2001
USA (NIMH II)  6  (detail)  75-IIIR----Negative
Sanders, 2001
USA, Australia  6  (detail)  36-IIIR----Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine SZ diagnosis ->  "IIIR"(DSM-IIIR), "IV" (DSM-IV), "9" (ICD-9), "10" (ICD-10), "M" (Mixed), "RDC" (Research Diagnostic Criteria), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
SZGene Recent Updates
SZGene Stats
Studies: 1727
Genes: 1008
Polymorphisms: 8788
Meta-analyses: 287
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SZGene
An up-to-date collection of all published genetic association studies.
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