Schizophrenia Research Forum - A Catalyst for Creative Thinking
Home Your Profile Become a Member/Get Newsletter Contact Us
What's New
Recent Updates
SRF Papers
Current Papers
Search All Papers
Search Comments
News
Research News
Forums
Current Hypotheses
Idea Lab
Online Discussions
Virtual Conferences
Interviews
Tech Corner
Resources
What We Know
SchizophreniaGene
Animal Models
Drugs in Trials
Research Tools
Grants
Jobs
Conferences
Journals
Community Calendar
General Information
Community
Member Directory
Researcher Profiles
Institutes and Labs
About the Site
Mission
History
SRF Team
Advisory Board
Support Us
How to Cite
Fan (E)Mail
The Schizophrenia Research Forum web site is sponsored by NARSAD, the Brain and Behavior Research Fund, and was created with funding from the U.S. National Institute of Mental Health.
Printable version  
SZGene - Gene overview of all published SZ-association studies for DRD4    
Back Search Methods Disclaimer Credits
 Gene: DRD4  (D4DR)  Entrez Gene    View on AlzGene   View on PDGene
 Protein: dopamine receptor D4  (D(2C) dopamine receptor; seven transmembrane helix receptor)  ProteinLink
 Chromosome: 11   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 21 October 2010
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      SZ Cases Normal Controls    
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Alfimova, 2007
Russia CL  2  (detail)  150
(54%)
10-34.3 + 12.7
(-)
118
(43%)
35.5 + 13
(-)
Negative
Campion, 1994
France CL  1  (detail)  80
(-)
III--80
(-)
-Negative
Catalano, 1993
Italy CL  1  (detail)  79
(43%)
IIIR21.9 + 4.7
(13-34)
34.1 + 11.1
(16-73)
75
(57%)
30 + 7.1
(20-52)
Negative
Cichon, 1995
Germany CL  2  (detail)  256
(-)
IIIR24.6 + 7.3
(-)
31.8 + 9.8
(-)
148
(-)
30.6 + 9.1
(-)
Negative
Daniels, 1994
UK CL  1  (detail)  106
(44%)
IIIR-46.3 + 15.8
(-)
119
(40%)
49.6 + 18.8
(-)
Negative
Dollfus, 1996
France CL  1  (detail)  62
(-)
IIIR--161
(-)
-Negative
Hoogendoorn, 2005
Netherlands CL  1  (detail)  282
(-)
IV--585
(-)
-Negative
Jonsson, 1996
Sweden CL  1  (detail)  118
(36%)
IIIR-45.8
(20-90)
78
(42%)
38.7 + 29
(56-56)
Negative
Jonsson, 2001
Sweden CL  1  (detail)  132
(36%)
IIIR-44.8 + 17.1
(-)
388
(44%)
42.6 + 13.3
(-)
Negative
Kaiser, 2000
Germany CL  1  (detail)  638
(45%)
IV27 + 9.5
(12-66)
37 + 12.2
(18-70)
752
(25%)
-Negative
Kohn, 1997
Israel CL  2  (detail)  98
(-)
IIIR--204
(-)
-Negative
Kotler, 1999
Israel CL  1  (detail)  92
(35%)
10--415
(0%)
28 + 15
(-)
Negative
Nothen, 1993
Germany CL  1  (detail)  60
(33%)
IIIR25.2 + 8
(14-46)
34.8 + 11
(-)
60
(47%)
28.2 + 5.2
(-)
Negative
Nothen, 1994
Germany CL  1  (detail)  118
(-)
IIIR--232
(-)
-Negative
Olsen, 2005
Denmark CL  1  (detail)  242
(38%)
10-42.9 + 12.3
(-)
178
(39%)
46.9 + 9.1
(-)
Negative
Pal, 2009
Croatia CL  4  (detail)  103
(42%)
10-43.6 + 10.6
(23-74)
131
(-)
50.3 + 7.5
(30-74)
Positive
Paterson, 1996
USA, Canada CL  1  (detail)  45
(-)
IIIR--41
(-)
-Negative
Sanak, 2005
Poland CL  1  (detail)  237
(50%)
M-37.7 + 12.7
(-)
241
(59%)
36.8 + 9.3
(-)
Trend
Serretti, 1999
Italy CL  2  (detail)  229
(31%)
IIIR22.3 + 11.2
(-)
35.2 + 13.9
(-)
471
(55%)
42.5 + 13.9
(-)
Negative
Serretti, 2001
Italy CL  1  (detail)  419
(-)
IV--601
(56%)
47.4 + 14.9
(-)
Negative
Sommer, 1993
USA CL  1  (detail)  115
(30%)
IIIR26.6 + 7.4
(-)
38.3 + 12
(-)
115
(62%)
65 + 12.2
(-)
Negative
Talkowski, 2008
USA CL  3  (detail)  328
(-)
IV--501
(-)
-Negative
Weiss, 1996
Germany CL  1  (detail)  91
(57%)
10-36.6
(-)
92
(43%)
41.5
(-)
Positive
 African Descent
Seeman, 1994
USA, Canada, Caribbean CL  1  (detail)  183
(-)
IIIR--24
(-)
-Negative
 Asian
Fujiwara, 1997
Japan CL  1  (detail)  17
(-)
M--11
(-)
-Positive
Hattori, 2008
Japan CL  1  (detail)  570
(50%)
IV-47 + 11.4
(-)
570
(50%)
46.7 + 11.1
(-)
Negative
Hokyo, 2010
Japan CL  1  (detail)  407
(42%)
IV-54.7
(-)
384
(64%)
40.1
(-)
Negative
Hong, 1997
Taiwan CL  1  (detail)  42
(50%)
IIIR-30.8 + 8
(-)
42
(38%)
28.7 + 4.4
(-)
Negative
Hong, 1998
Taiwan CL  1  (detail)  80
(50%)
IIIR-29.2 + 6.6
(-)
42
(38%)
28.7 + 4.4
(-)
Negative
Iwata, 2003
Japan CL  1  (detail)  51
(57%)
IV13.5 + 1.7
(9-16)
20 + 7
(-)
148
(56%)
21 + 7
(-)
Negative
Lai, 2010
China CL  3  (detail)  322
(48%)
IIIR-40.6 + 16.8
(-)
300
(50%)
43.2 + 17.6
(-)
Positive
Lung, 2002
Taiwan CL  1  (detail)  305
(-)
IIIR--80
(-)
-Negative
Lung, 2006
Taiwan CO  2  (detail)  630
(-)
IIIR-35.3 + 10.8
(-)
428
(-)
45.3 + 13.9
(-)
Positive
Lung, 2009
Taiwan CL  1  (detail)  934
(31%)
IV-36.6 + 12.2
(-)
433
(56%)
45.3 + 13.9
(-)
Positive
Mitsuyasu, 2001
Overlaps with
Mitsuyasu, 2006
CL  5  (detail)  208
(44%)
IV-51.5 + 13.9
(-)
210
(43%)
50.5 + 5
(-)
n.a.
Mitsuyasu, 2006
Japan CL  17  (detail)  216
(44%)
IV-51.5 + 13.7
(18-82)
243
(43%)
50.2 + 4.6
(30-71)
Negative
Nakajima, 2006
Japan CL  9  (detail)  570
(50%)
IV-47 + 11.4
(-)
570
(50%)
46.7 + 11.1
(-)
Positive
Nakamura, 1995
Japan CL  1  (detail)  110
(-)
U-47.3
(-)
52
(-)
32.8
(-)
Positive
Nanko, 1993
Japan CL  1  (detail)  80
(-)
U--81
(-)
-Negative
Ohara, 1996
Japan CL  2  (detail)  153
(50%)
IV26.3 + 9.5
(-)
46.3 + 16
(-)
121
(58%)
34.4 + 14.1
(-)
Negative
Okuyama, 1999
Japan CL  1  (detail)  252
(40%)
IIIR24.3
(15-47)
47.1
(20-80)
269
(39%)
47.9
(35-75)
Positive
Tanaka, 1995
Japan CL  1  (detail)  70
(46%)
IIIR-44.7 + 11.8
(15-70)
70
(36%)
45.8 + 25
(22-86)
Negative
Tani, 1997
Japan CL  1  (detail)  49
(31%)
IIIR28.4 + 6.9
(17-40)
54.9 + 10.9
(25-72)
50
(30%)
54.6 + 11.5
(29-79)
Negative
Xing, 2003
China CL  7  (detail)  210
(-)
IIIR-41.2 + 16.9
(-)
206
(50%)
41.8 + 16.2
(-)
Positive
 Hispanic
Aguirre, 2007
Mexico CL  2  (detail)  94
(-)
IIIR--169
(49%)
40 + 14
(19-70)
Positive
Fresan, 2007
Mexico CL  1  (detail)  71
(31%)
IV21.4 + 6.2
(11-42)
30.5 + 7.9
(18-47)
202
(49%)
36.4 + 11.4
(-)
n.a.
 Other/Mixed
Petronis, 1995
USA, Canada CL  4  (detail)  50
(-)
IIIR--50
(-)
-Trend
Rao, 1994
USA CL  1  (detail)  41
(-)
IIIR--27
(-)
-Negative
Srivastava, 2010
India CL  3  (detail)  215
(48%)
IV21.4 + 6.1
(-)
29.3 + 8.9
(-)
215
(40%)
34.6 + 12.4
(-)
Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds    
Study Population # Polys # Families # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Ambrosio, 2004
Portugal  3  (detail)  9090
(36%)
IV--180
(50%)
-Negative
Campion, 1994
France  1  (detail)  37-IIIR--80
(-)
-Negative
Fallin, 2005
USA  1  (detail)  263274
(26%)
IV19.5 + 4.5
(-)
-548
(50%)
-Negative
Macciardi, 1994
Italy  1  (detail)  4242
(26%)
IIIR-26
(19-45)
84
(50%)
-Negative
Talkowski, 2008
USA  3  (detail)  150150
(50%)
IV--300
(50%)
-Negative
 Asian
Hattori, 2008
Japan  1  (detail)  124163
(-)
IV--213
(-)
-Negative
Hong, 1997
Taiwan  1  (detail)  4747
(32%)
IIIR-34 + 8.1
(-)
35
(43%)
34.1 + 9
(-)
Negative
 Other/Mixed
Fanous, 2004
USA  1  (detail)   540
(-)
IIIR--709
(-)
-Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine SZ diagnosis ->  "IIIR"(DSM-IIIR), "IV" (DSM-IV), "9" (ICD-9), "10" (ICD-10), "M" (Mixed), "RDC" (Research Diagnostic Criteria), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
SZGene Recent Updates
SZGene Stats
Studies: 1727
Genes: 1008
Polymorphisms: 8788
Meta-analyses: 287
ALSGene
AlzGene
MSGene
PDGene
SZGene
An up-to-date collection of all published genetic association studies.
SRF News
SRF Comments
Text Size
Reset Text Size
Email this pageEmail this page

Share/Bookmark
Research Participants
Collaborators
Copyright © 2005-2014 Schizophrenia Research Forum Privacy Policy Disclaimer Disclosure Copyright