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SZGene - Gene overview of all published SZ-association studies for SLC6A4    
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 Gene: SLC6A4  (HTT; 5HTT; OCD1; SERT; 5-HTT; hSERT)  Entrez Gene    View on AlzGene   View on PDGene
 Protein: solute carrier family 6 member 4  (5HT transporter; serotonin transporter; 5-hydroxytryptamine transporter; sodium-dependent serotonin transporter; Na+/Cl- dependent serotonin transporter)  ProteinLink
 Chromosome: 17   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 22 October 2010
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      SZ Cases Normal Controls    
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Bayle, 2003
France CL  1  (detail)  185
(30%)
IV-32 + 9
(-)
159
(35%)
35 + 10
(-)
Negative
Bonnet-Brilhault, 1997
France CL  1  (detail)  105
(30%)
IIIR--114
(48%)
-Negative
Chotai, 2005
Overlaps with
Serretti, 2002
CL  1  (detail)  114
(24%)
IV22 + 5
(-)
36 + 9
(-)
241
(42%)
54 + 13
(-)
n.a.
Collier, 1996
UK CL  1  (detail)  129
(-)
IIIR--187
(-)
-Trend
Dutt, 2009
UK, Ireland CL  1  (detail)  83
(-)
IV--57
(-)
-Negative
Golimbet, 2003
Russia CL  2  (detail)  110
(43%)
1023.7 + 5.8
(-)
25.3 + 6.7
(-)
124
(63%)
31.6 + 13.5
(-)
Negative
Herken, 2002
Turkey CL  1  (detail)  128
(-)
IV--135
(-)
-Negative
Herken, 2003a
Turkey CL  2  (detail)  143
(35%)
IV-32.3 + 9.1
(-)
79
(-)
-Negative
Kaiser, 2001
Germany CL  2  (detail)  684
(47%)
IV27 + 9.3
(12-66)
38.5 + 12.1
(18-70)
587
(22%)
30.1 + 7.6
(18-58)
Trend
Kotler, 1999
Israel CL  1  (detail)  92
(37%)
10--415
(62%)
28 + 15
(-)
Negative
Mata, 2004
Spain CL  2  (detail)  200
(-)
IV--334
(47%)
26.8 + 5.4
(-)
Negative
Meda, 2009
USA CL  2  (detail)  31
(-)
IV--35
(-)
-Negative
Mendes de Oliveira, 1998
Brazil CL  1  (detail)  39
(-)
IV--98
(-)
-Negative
Naylor, 1998
Australia CL  1  (detail)  58
(-)
IIIR--62
(-)
-Negative
Pal, 2009
Croatia CL  4  (detail)  103
(42%)
10-43.6 + 10.6
(23-74)
131
(-)
50.3 + 7.5
(30-74)
Positive
Rao, 1998
USA CL  1  (detail)  80
(40%)
IV-37.4 + 10
(-)
127
(66%)
30 + 10.3
(-)
Negative
Rao, 1998
Overlaps with
Zaboli, 2007
CL  1  (detail)  122
(35%)
IIIR-45 + 17.3
(-)
99
(34%)
38.2 + 6.3
(-)
n.a.
Saiz, 2007
Spain CL  2  (detail)  227
(40%)
IV-35.7 + 11.7
(-)
420
(49%)
40.6 + 11.3
(-)
Negative
Sanjuan, 2006
Spain CL  1  (detail)  158
(31%)
IV-38.4 + 11.6
(-)
138
(-)
-Positive
Serretti, 2002
Italy CL  1  (detail)  261
(-)
IV--457
(51%)
46 + 15.5
(-)
Negative
Stober, 1998
Germany CL  2  (detail)  180
(38%)
1026.5 + 9.7
(-)
-233
(41%)
29.9 + 10
(-)
Negative
Zaboli, 2007
Sweden CL  4  (detail)  155
(40%)
M24.2 + 7.3
(-)
43.8 + 16.5
(-)
246
(39%)
41 + 11.2
(-)
Positive
 African Descent
Rao, 1998
USA CL  1  (detail)  47
(43%)
IV-35.2 + 9.3
(-)
37
(57%)
30 + 8
(-)
Negative
 Asian
Chong, 2000
China CL  1  (detail)  338
(36%)
IV--103
(-)
-Negative
Han, 2004
Korea CL  1  (detail)  168
(0%)
IV--158
(0%)
-Negative
Ikeda, 2006
Japan CL  6  (detail)  287
(48%)
IV-42.3 + 14.7
(-)
288
(48%)
33.6 + 12.9
(-)
Negative
Lee, 2009
Korea CL  2  (detail)  141
(57%)
IV-34 + 10.7
(-)
115
(47%)
33.5 + 10.3
(-)
Negative
Lin, 2009
China PO  4  (detail)  329
(38%)
IV-49.5 + 11.4
(-)
288
(45%)
37 + 8.1
(-)
Positive
Liu, 1999
China CL  1  (detail)  255
(42%)
IIIR-42 + 15.3
(-)
362
(45%)
42 + 10.2
(-)
Positive
Pae, 2003
Korea CL  1  (detail)  111
(52%)
IV24.7
(-)
30.3 + 9.4
(-)
208
(45%)
23.8 + 4.3
(-)
Negative
Pae, 2005
Overlaps with
Pae, 2003
CL  1  (detail)  111
(52%)
IV-30.3 + 9.4
(-)
172
(53%)
25 + 9.9
(-)
n.a.
Pae, 2006
Korea CL  1  (detail)  152
(52%)
IV-26.9 + 11.6
(-)
152
(55%)
32 + 10.7
(-)
Negative
Tsai, 2000
China CL  1  (detail)  90
(34%)
IV-37.1 + 0.9
(-)
104
(72%)
49.6 + 0.8
(-)
Negative
Tsai, 2002
Taiwan CL  1  (detail)  114
(59%)
IIIR-44.5 + 11.1
(-)
127
(65%)
42.8 + 9.2
(-)
Positive
 Other/Mixed
Konneker, 2010
USA CL  2  (detail)  738
(26%)
IV--733
(33%)
-Negative
Vijayan, 2009
India CL  5  (detail)  243
(66%)
IV-33 + 11
(-)
243
(-)
31.7 + 6.9
(-)
Positive
Young, 2006
USA CL  1  (detail)  12
(-)
U--15
(-)
-Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds    
Study Population # Polys # Families # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Dimitrova, 2002
Bulgaria  1  (detail)  266-IIIR----Negative
Dubertret, 2005
France  2  (detail)  103103
(21%)
IV20.8 + 8.1
(-)
31.4 + 7.7
(-)
206
(50%)
59.8 + 7.8
(-)
Positive
Hranilovic, 2000
Germany, Israel  2  (detail)  61139
(-)
IIIR--266
(50%)
-Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine SZ diagnosis ->  "IIIR"(DSM-IIIR), "IV" (DSM-IV), "9" (ICD-9), "10" (ICD-10), "M" (Mixed), "RDC" (Research Diagnostic Criteria), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
SZGene Recent Updates
SZGene Stats
Studies: 1727
Genes: 1008
Polymorphisms: 8788
Meta-analyses: 287
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