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Printable version
SZGene - Gene overview of all published SZ-association studies for BDNF
Gene:
BDNF
(MGC34632)
View on AlzGene
View on MSGene
View on PDGene
Protein:
brain-derived neurotrophic factor
(neurotrophin)
Chromosome:
11
(View:
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
X
Y
MT
)
Status:
Updated 21 October 2010
1. Case-Control Studies (by ethnic group)
SZ Cases
Normal Controls
Study
Population
Source
# Polys
# Subjects
(% women)
DX
Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
Comment
Caucasian
Agartz, 2006
Overlaps with
Jonsson, 2006
CL
4
(detail)
96
(26%)
M
24.6 + 5.9
(-)
42 + 7.3
(-)
104
(34%)
41.6 + 8.9
(-)
n.a.
Antilla, 2005
Finland
CL
2
(detail)
94
(-)
IV
-
-
98
(-)
-
Negative
Betcheva, 2009
Bulgaria
CL
1
(detail)
185
(-)
IV
-
-
184
(-)
-
Negative
de Krom, 2005
Netherlands
CL
4
(detail)
273
(-)
IV
-
-
580
(-)
-
Negative
Donohoe, 2007
Ireland
CL
1
(detail)
359
(-)
U
-
-
745
(-)
-
Negative
Dutt, 2009
UK, Ireland
CL
1
(detail)
83
(-)
IV
-
-
57
(-)
-
Negative
Galderisi, 2005
Italy
CL
1
(detail)
106
(28%)
IV
-
-
111
(-)
-
Negative
Gourion, 2005
France
CL
1
(detail)
210
(32%)
IV
21.6 + 4.8
(-)
31.4 + 8.5
(-)
99
(54%)
30.5 + 9.9
(-)
Negative
Hall, 2007
Overlaps with
Jonsson, 2006
CL
1
(detail)
103
(38%)
M
-
42.4 + 11.5
(-)
89
(33%)
39.2 + 11.5
(-)
n.a.
Hawi, 1998
Ireland
CL
1
(detail)
220
(32%)
IIIR
-
-
234
(45%)
-
Negative
Ho, 2006
USA
CL
1
(detail)
293
(27%)
M
21.5 + 6.7
(-)
27.3 + 9.2
(-)
144
(55%)
27.9 + 8.1
(-)
Positive
Jonsson, 2006
Sweden
CL
4
(detail)
187
(37%)
M
-
44.3 + 15.8
(-)
275
(37%)
40.5 + 9.8
(-)
Negative
Jungerius, 2007
Netherlands
CL
4
(detail)
310
(-)
IV
-
-
880
(-)
-
Negative
Koolschijn, 2009
Overlaps with
de Krom, 2005
CL
1
(detail)
87
(18%)
IV
-
36 + 12.7
(17-68)
90
(38%)
38.1 + 13.5
(17-65)
n.a.
Krebs, 2000
France
CL
1
(detail)
88
(-)
IIIR
-
-
52
(-)
-
Positive
Lencz, 2009
USA
CL
5
(detail)
211
(26%)
IV
-
38.3 + 10.3
(-)
222
(59%)
47.6 + 18.6
(-)
Negative
Meda, 2009
USA
CL
1
(detail)
31
(-)
IV
-
-
35
(-)
-
Negative
Neves-Pereira, 2005
UK (Scotland)
CL
2
(detail)
321
(-)
IV
-
-
350
(-)
-
Positive
Schumacher, 2005
Germany
CL
3
(detail)
533
(56%)
IV
-
36.8 + 11.5
(-)
1097
(50%)
44.5 + 15.8
(-)
Trend
Shaikh, 2010
Overlaps with
Dutt, 2009
CL
1
(detail)
70
(-)
IV
-
-
204
(63%)
40.1 + 13.2
(18-65)
n.a.
Skibinska, 2004
Poland
CL
1
(detail)
336
(44%)
M
-
31.7 + 11.7
(-)
375
(60%)
40.7 + 11.3
(-)
Negative
Squassina, 2010
Italy
CL
3
(detail)
171
(30%)
IV
-
36.7 + 9.7
(-)
349
(36%)
38.6 + 10.1
(-)
Negative
Szczepankiewicz, 2005
Poland
CL
1
(detail)
397
(45%)
M
-
31.2 + 11.5
(-)
380
(62%)
41 + 12.1
(-)
Negative
Szekeres, 2003
Finland
CL
1
(detail)
101
(39%)
IV
-
39.8 + 11.8
(-)
68
(43%)
36.8 + 11.1
(-)
Positive
Varnaes, 2008
Overlaps with
Jonsson, 2006
CL
4
(detail)
96
(26%)
IV
24.6 + 5.9
(-)
42 + 7.3
(-)
104
(34%)
41.6 + 8.9
(-)
n.a.
Virgos, 2001
Spain
CL
1
(detail)
262
(40%)
9
-
61.4
(19-90)
278
(39%)
54.2
(21-90)
Negative
Zai, 2010
Canada
CL
4
(detail)
167
(37%)
IV
-
37.5 + 10.8
(-)
167
(37%)
-
Negative
Zhang, 2006
USA
CL
3
(detail)
84
(40%)
M
-
37.5 + 19.7
(-)
250
(59%)
37.5 + 19.7
(-)
Negative
Asian
Chang, 2009
Taiwan
CL
1
(detail)
251
(36%)
U
-
36.3 + 12.8
(-)
284
(33%)
35.9 + 9.4
(-)
Negative
Chen, 2006
China
CL
3
(detail)
560
(47%)
IV
-
37.3 + 13.6
(-)
576
(48%)
33.2 + 10.5
(-)
Negative
Hong, 2003
Taiwan
CL
1
(detail)
93
(34%)
IV
-
36.8 + 8.1
(-)
198
(38%)
35.7 + 9.1
(-)
Trend
Kawashima, 2009
Japan
PO
8
(detail)
1117
(44%)
IV
-
47.4 + 15.3
(-)
1102
(54%)
37.1 + 14.4
(-)
Negative
Li, 2007
China
CL
1
(detail)
130
(38%)
IV
27.8 + 9
(-)
-
144
(36%)
-
Negative
Nanko, 2003
Japan
CL
2
(detail)
178
(49%)
IV
-
39.7 + 12.7
(-)
332
(55%)
44 + 16.6
(-)
Positive
Naoe, 2007
Japan
CL
1
(detail)
211
(47%)
IV
26.8 + 8.1
(-)
52.8 + 11.6
(-)
205
(49%)
54.9 + 6.9
(-)
Negative
Numata, 2006
Japan
CL
1
(detail)
159
(28%)
IV
25.9 + 8.3
(-)
53.9 + 12.8
(-)
318
(-)
-
Positive
Qian, 2007
China
CL
4
(detail)
617
(40%)
IV
-
45.9 + 12
(-)
672
(53%)
34.7 + 9
(-)
Positive
Sasaki, 1997
Japan
CL
1
(detail)
60
(-)
IIIR
-
-
60
(-)
-
Negative
Tan, 2005
China
CL
1
(detail)
108
(35%)
IV
-
-
145
(34%)
-
Negative
Tochigi, 2006
Japan
CL
1
(detail)
401
(45%)
IV
-
45.3 + 14.8
(-)
569
(55%)
35.6 + 11.5
(-)
Negative
Wang, 2010
China
CL
1
(detail)
815
(16%)
IV
23.4
(-)
48.1
(-)
546
(19%)
-
Negative
Watanabe, 2006
Japan
CL
3
(detail)
349
(46%)
IV
23.1 + 7.2
(-)
41.4 + 15
(-)
423
(49%)
34.2 + 7.7
(-)
Negative
Xu, 2007
China
PO
2
(detail)
275
(45%)
IV
-
43.3 + 11.5
(-)
297
(47%)
43.7 + 12.1
(-)
Negative
Zhou, 2010
China
CL
1
(detail)
387
(33%)
IV
-
50.5 + 9.9
(-)
365
(30%)
49.8 + 9.3
(-)
Negative
Other/Mixed
Egan, 2003
USA
CL
1
(detail)
203
(21%)
U
-
-
133
(45%)
-
Negative
Gupta, 2009
India
CL
1
(detail)
254
(39%)
IV
-
29.2 + 7.6
(-)
225
(62%)
86 + 31
(-)
Positive
Hashimoto, 2006
USA
CL
1
(detail)
27
(-)
U
-
-
27
(-)
-
Positive
Contact us
if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
Affecteds
Unaffecteds
Study
Population
# Polys
# Families
# Subjects
(% women)
DX
Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
Comment
Caucasian
Muglia, 2003
Mixed
1
(detail)
89
89
(-)
IIIR
-
-
188
(47%)
-
Positive
Rosa, 2006
Spain
1
(detail)
94
94
(22%)
IV
-
26.8 + 5.8
(-)
282
(51%)
-
Positive
Shaikh, 2010
Overlaps with
Dutt, 2009
1
(detail)
138
(40%)
IV
-
40.8 + 11.8
(21-65)
109
(53%)
45.9 + 12.8
(19-65)
Negative
Zai, 2010
Canada, USA
4
(detail)
95
-
IV
-
-
-
-
Negative
Other/Mixed
Fanous, 2004
USA
1
(detail)
270
595
(-)
IIIR
-
-
-
-
Trend
Wassink, 1999
USA
1
(detail)
48
48
(21%)
M
20.1 + 4.4
(-)
-
96
(50%)
-
Negative
Contact us
if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:
Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:
Number of polymorphisms tested per gene and per sample.
Onset Age and Age:
Mean or median age at onset or examination, respectively.
DX:
Criteria used to determine SZ diagnosis -> "IIIR"(DSM-IIIR), "IV" (DSM-IV), "9" (ICD-9), "10" (ICD-10), "M" (Mixed), "RDC" (Research Diagnostic Criteria), "U" (Unknown).
Result:
Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-)
: Either no data provided or in case of overlap, data included in original study.
SZGene Recent Updates
SZGene Stats
Studies: 1727
Genes: 1008
Polymorphisms: 8788
Meta-analyses: 287
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