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SZGene - Gene overview of all published SZ-association studies for BDNF    
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 Gene: BDNF  (MGC34632)  Entrez Gene    View on AlzGene   View on MSGene   View on PDGene
 Protein: brain-derived neurotrophic factor  (neurotrophin)  ProteinLink
 Chromosome: 11   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 21 October 2010
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      SZ Cases Normal Controls    
Study Population Source # Polys # Subjects
(% women)		 DX Onset Age
(range)		 Age
(range)		 # Subjects
(% women)		 Age
(range)		 Result Comment
 Caucasian
Agartz, 2006
 Overlaps with
Jonsson, 2006		 CL  4  (detail)  96
(26%)		M24.6 + 5.9
(-)		42 + 7.3
(-)		104
(34%)		41.6 + 8.9
(-)		n.a.
Antilla, 2005
 Finland CL  2  (detail)  94
(-)		IV--98
(-)		-Negative
Betcheva, 2009
 Bulgaria CL  1  (detail)  185
(-)		IV--184
(-)		-Negative
de Krom, 2005
 Netherlands CL  4  (detail)  273
(-)		IV--580
(-)		-Negative
Donohoe, 2007
 Ireland CL  1  (detail)  359
(-)		U--745
(-)		-Negative
Dutt, 2009
 UK, Ireland CL  1  (detail)  83
(-)		IV--57
(-)		-Negative
Galderisi, 2005
 Italy CL  1  (detail)  106
(28%)		IV--111
(-)		-Negative
Gourion, 2005
 France CL  1  (detail)  210
(32%)		IV21.6 + 4.8
(-)		31.4 + 8.5
(-)		99
(54%)		30.5 + 9.9
(-)		Negative
Hall, 2007
 Overlaps with
Jonsson, 2006		 CL  1  (detail)  103
(38%)		M-42.4 + 11.5
(-)		89
(33%)		39.2 + 11.5
(-)		n.a.
Hawi, 1998
 Ireland CL  1  (detail)  220
(32%)		IIIR--234
(45%)		-Negative
Ho, 2006
 USA CL  1  (detail)  293
(27%)		M21.5 + 6.7
(-)		27.3 + 9.2
(-)		144
(55%)		27.9 + 8.1
(-)		Positive
Jonsson, 2006
 Sweden CL  4  (detail)  187
(37%)		M-44.3 + 15.8
(-)		275
(37%)		40.5 + 9.8
(-)		Negative
Jungerius, 2007
 Netherlands CL  4  (detail)  310
(-)		IV--880
(-)		-Negative
Koolschijn, 2009
 Overlaps with
de Krom, 2005		 CL  1  (detail)  87
(18%)		IV-36 + 12.7
(17-68)		90
(38%)		38.1 + 13.5
(17-65)		n.a.
Krebs, 2000
 France CL  1  (detail)  88
(-)		IIIR--52
(-)		-Positive
Lencz, 2009
 USA CL  5  (detail)  211
(26%)		IV-38.3 + 10.3
(-)		222
(59%)		47.6 + 18.6
(-)		Negative
Meda, 2009
 USA CL  1  (detail)  31
(-)		IV--35
(-)		-Negative
Neves-Pereira, 2005
 UK (Scotland) CL  2  (detail)  321
(-)		IV--350
(-)		-Positive
Schumacher, 2005
 Germany CL  3  (detail)  533
(56%)		IV-36.8 + 11.5
(-)		1097
(50%)		44.5 + 15.8
(-)		Trend
Shaikh, 2010
 Overlaps with
Dutt, 2009		 CL  1  (detail)  70
(-)		IV--204
(63%)		40.1 + 13.2
(18-65)		n.a.
Skibinska, 2004
 Poland CL  1  (detail)  336
(44%)		M-31.7 + 11.7
(-)		375
(60%)		40.7 + 11.3
(-)		Negative
Squassina, 2010
 Italy CL  3  (detail)  171
(30%)		IV-36.7 + 9.7
(-)		349
(36%)		38.6 + 10.1
(-)		Negative
Szczepankiewicz, 2005
 Poland CL  1  (detail)  397
(45%)		M-31.2 + 11.5
(-)		380
(62%)		41 + 12.1
(-)		Negative
Szekeres, 2003
 Finland CL  1  (detail)  101
(39%)		IV-39.8 + 11.8
(-)		68
(43%)		36.8 + 11.1
(-)		Positive
Varnaes, 2008
 Overlaps with
Jonsson, 2006		 CL  4  (detail)  96
(26%)		IV24.6 + 5.9
(-)		42 + 7.3
(-)		104
(34%)		41.6 + 8.9
(-)		n.a.
Virgos, 2001
 Spain CL  1  (detail)  262
(40%)		9-61.4
(19-90)		278
(39%)		54.2
(21-90)		Negative
Zai, 2010
 Canada CL  4  (detail)  167
(37%)		IV-37.5 + 10.8
(-)		167
(37%)		-Negative
Zhang, 2006
 USA CL  3  (detail)  84
(40%)		M-37.5 + 19.7
(-)		250
(59%)		37.5 + 19.7
(-)		Negative
 Asian
Chang, 2009
 Taiwan CL  1  (detail)  251
(36%)		U-36.3 + 12.8
(-)		284
(33%)		35.9 + 9.4
(-)		Negative
Chen, 2006
 China CL  3  (detail)  560
(47%)		IV-37.3 + 13.6
(-)		576
(48%)		33.2 + 10.5
(-)		Negative
Hong, 2003
 Taiwan CL  1  (detail)  93
(34%)		IV-36.8 + 8.1
(-)		198
(38%)		35.7 + 9.1
(-)		Trend
Kawashima, 2009
 Japan PO  8  (detail)  1117
(44%)		IV-47.4 + 15.3
(-)		1102
(54%)		37.1 + 14.4
(-)		Negative
Li, 2007
 China CL  1  (detail)  130
(38%)		IV27.8 + 9
(-)		-144
(36%)		-Negative
Nanko, 2003
 Japan CL  2  (detail)  178
(49%)		IV-39.7 + 12.7
(-)		332
(55%)		44 + 16.6
(-)		Positive
Naoe, 2007
 Japan CL  1  (detail)  211
(47%)		IV26.8 + 8.1
(-)		52.8 + 11.6
(-)		205
(49%)		54.9 + 6.9
(-)		Negative
Numata, 2006
 Japan CL  1  (detail)  159
(28%)		IV25.9 + 8.3
(-)		53.9 + 12.8
(-)		318
(-)		-Positive
Qian, 2007
 China CL  4  (detail)  617
(40%)		IV-45.9 + 12
(-)		672
(53%)		34.7 + 9
(-)		Positive
Sasaki, 1997
 Japan CL  1  (detail)  60
(-)		IIIR--60
(-)		-Negative
Tan, 2005
 China CL  1  (detail)  108
(35%)		IV--145
(34%)		-Negative
Tochigi, 2006
 Japan CL  1  (detail)  401
(45%)		IV-45.3 + 14.8
(-)		569
(55%)		35.6 + 11.5
(-)		Negative
Wang, 2010
 China CL  1  (detail)  815
(16%)		IV23.4
(-)		48.1
(-)		546
(19%)		-Negative
Watanabe, 2006
 Japan CL  3  (detail)  349
(46%)		IV23.1 + 7.2
(-)		41.4 + 15
(-)		423
(49%)		34.2 + 7.7
(-)		Negative
Xu, 2007
 China PO  2  (detail)  275
(45%)		IV-43.3 + 11.5
(-)		297
(47%)		43.7 + 12.1
(-)		Negative
Zhou, 2010
 China CL  1  (detail)  387
(33%)		IV-50.5 + 9.9
(-)		365
(30%)		49.8 + 9.3
(-)		Negative
 Other/Mixed
Egan, 2003
 USA CL  1  (detail)  203
(21%)		U--133
(45%)		-Negative
Gupta, 2009
 India CL  1  (detail)  254
(39%)		IV-29.2 + 7.6
(-)		225
(62%)		86 + 31
(-)		Positive
Hashimoto, 2006
 USA CL  1  (detail)  27
(-)		U--27
(-)		-Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds    
Study Population # Polys # Families # Subjects
(% women)		 DX Onset Age
(range)		 Age
(range)		 # Subjects
(% women)		 Age
(range)		 Result Comment
 Caucasian
Muglia, 2003
 Mixed  1  (detail)  8989
(-)		IIIR--188
(47%)		-Positive
Rosa, 2006
 Spain  1  (detail)  9494
(22%)		IV-26.8 + 5.8
(-)		282
(51%)		-Positive
Shaikh, 2010
 Overlaps with
Dutt, 2009		  1  (detail)   138
(40%)		IV-40.8 + 11.8
(21-65)		109
(53%)		45.9 + 12.8
(19-65)		Negative
Zai, 2010
 Canada, USA  4  (detail)  95-IV----Negative
 Other/Mixed
Fanous, 2004
 USA  1  (detail)  270595
(-)		IIIR----Trend
Wassink, 1999
 USA  1  (detail)  4848
(21%)		M20.1 + 4.4
(-)		-96
(50%)		-Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine SZ diagnosis ->  "IIIR"(DSM-IIIR), "IV" (DSM-IV), "9" (ICD-9), "10" (ICD-10), "M" (Mixed), "RDC" (Research Diagnostic Criteria), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
SZGene Recent Updates
SZGene Stats
Studies: 1727
Genes: 1008
Polymorphisms: 8788
Meta-analyses: 287
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