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SZGene - Gene overview of all published SZ-association studies for BDNF    
Back Search Methods Disclaimer Credits
 Gene: BDNF  (MGC34632)  Entrez Gene    View on AlzGene   View on MSGene   View on PDGene
 Protein: brain-derived neurotrophic factor  (neurotrophin)  ProteinLink
 Chromosome: 11   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 21 October 2010
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      SZ Cases Normal Controls    
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Agartz, 2006
Overlaps with
Jonsson, 2006
CL  4  (detail)  96
(26%)
M24.6 + 5.9
(-)
42 + 7.3
(-)
104
(34%)
41.6 + 8.9
(-)
n.a.
Antilla, 2005
Finland CL  2  (detail)  94
(-)
IV--98
(-)
-Negative
Betcheva, 2009
Bulgaria CL  1  (detail)  185
(-)
IV--184
(-)
-Negative
de Krom, 2005
Netherlands CL  4  (detail)  273
(-)
IV--580
(-)
-Negative
Donohoe, 2007
Ireland CL  1  (detail)  359
(-)
U--745
(-)
-Negative
Dutt, 2009
UK, Ireland CL  1  (detail)  83
(-)
IV--57
(-)
-Negative
Galderisi, 2005
Italy CL  1  (detail)  106
(28%)
IV--111
(-)
-Negative
Gourion, 2005
France CL  1  (detail)  210
(32%)
IV21.6 + 4.8
(-)
31.4 + 8.5
(-)
99
(54%)
30.5 + 9.9
(-)
Negative
Hall, 2007
Overlaps with
Jonsson, 2006
CL  1  (detail)  103
(38%)
M-42.4 + 11.5
(-)
89
(33%)
39.2 + 11.5
(-)
n.a.
Hawi, 1998
Ireland CL  1  (detail)  220
(32%)
IIIR--234
(45%)
-Negative
Ho, 2006
USA CL  1  (detail)  293
(27%)
M21.5 + 6.7
(-)
27.3 + 9.2
(-)
144
(55%)
27.9 + 8.1
(-)
Positive
Jonsson, 2006
Sweden CL  4  (detail)  187
(37%)
M-44.3 + 15.8
(-)
275
(37%)
40.5 + 9.8
(-)
Negative
Jungerius, 2007
Netherlands CL  4  (detail)  310
(-)
IV--880
(-)
-Negative
Koolschijn, 2009
Overlaps with
de Krom, 2005
CL  1  (detail)  87
(18%)
IV-36 + 12.7
(17-68)
90
(38%)
38.1 + 13.5
(17-65)
n.a.
Krebs, 2000
France CL  1  (detail)  88
(-)
IIIR--52
(-)
-Positive
Lencz, 2009
USA CL  5  (detail)  211
(26%)
IV-38.3 + 10.3
(-)
222
(59%)
47.6 + 18.6
(-)
Negative
Meda, 2009
USA CL  1  (detail)  31
(-)
IV--35
(-)
-Negative
Neves-Pereira, 2005
UK (Scotland) CL  2  (detail)  321
(-)
IV--350
(-)
-Positive
Schumacher, 2005
Germany CL  3  (detail)  533
(56%)
IV-36.8 + 11.5
(-)
1097
(50%)
44.5 + 15.8
(-)
Trend
Shaikh, 2010
Overlaps with
Dutt, 2009
CL  1  (detail)  70
(-)
IV--204
(63%)
40.1 + 13.2
(18-65)
n.a.
Skibinska, 2004
Poland CL  1  (detail)  336
(44%)
M-31.7 + 11.7
(-)
375
(60%)
40.7 + 11.3
(-)
Negative
Squassina, 2010
Italy CL  3  (detail)  171
(30%)
IV-36.7 + 9.7
(-)
349
(36%)
38.6 + 10.1
(-)
Negative
Szczepankiewicz, 2005
Poland CL  1  (detail)  397
(45%)
M-31.2 + 11.5
(-)
380
(62%)
41 + 12.1
(-)
Negative
Szekeres, 2003
Finland CL  1  (detail)  101
(39%)
IV-39.8 + 11.8
(-)
68
(43%)
36.8 + 11.1
(-)
Positive
Varnaes, 2008
Overlaps with
Jonsson, 2006
CL  4  (detail)  96
(26%)
IV24.6 + 5.9
(-)
42 + 7.3
(-)
104
(34%)
41.6 + 8.9
(-)
n.a.
Virgos, 2001
Spain CL  1  (detail)  262
(40%)
9-61.4
(19-90)
278
(39%)
54.2
(21-90)
Negative
Zai, 2010
Canada CL  4  (detail)  167
(37%)
IV-37.5 + 10.8
(-)
167
(37%)
-Negative
Zhang, 2006
USA CL  3  (detail)  84
(40%)
M-37.5 + 19.7
(-)
250
(59%)
37.5 + 19.7
(-)
Negative
 Asian
Chang, 2009
Taiwan CL  1  (detail)  251
(36%)
U-36.3 + 12.8
(-)
284
(33%)
35.9 + 9.4
(-)
Negative
Chen, 2006
China CL  3  (detail)  560
(47%)
IV-37.3 + 13.6
(-)
576
(48%)
33.2 + 10.5
(-)
Negative
Hong, 2003
Taiwan CL  1  (detail)  93
(34%)
IV-36.8 + 8.1
(-)
198
(38%)
35.7 + 9.1
(-)
Trend
Kawashima, 2009
Japan PO  8  (detail)  1117
(44%)
IV-47.4 + 15.3
(-)
1102
(54%)
37.1 + 14.4
(-)
Negative
Li, 2007
China CL  1  (detail)  130
(38%)
IV27.8 + 9
(-)
-144
(36%)
-Negative
Nanko, 2003
Japan CL  2  (detail)  178
(49%)
IV-39.7 + 12.7
(-)
332
(55%)
44 + 16.6
(-)
Positive
Naoe, 2007
Japan CL  1  (detail)  211
(47%)
IV26.8 + 8.1
(-)
52.8 + 11.6
(-)
205
(49%)
54.9 + 6.9
(-)
Negative
Numata, 2006
Japan CL  1  (detail)  159
(28%)
IV25.9 + 8.3
(-)
53.9 + 12.8
(-)
318
(-)
-Positive
Qian, 2007
China CL  4  (detail)  617
(40%)
IV-45.9 + 12
(-)
672
(53%)
34.7 + 9
(-)
Positive
Sasaki, 1997
Japan CL  1  (detail)  60
(-)
IIIR--60
(-)
-Negative
Tan, 2005
China CL  1  (detail)  108
(35%)
IV--145
(34%)
-Negative
Tochigi, 2006
Japan CL  1  (detail)  401
(45%)
IV-45.3 + 14.8
(-)
569
(55%)
35.6 + 11.5
(-)
Negative
Wang, 2010
China CL  1  (detail)  815
(16%)
IV23.4
(-)
48.1
(-)
546
(19%)
-Negative
Watanabe, 2006
Japan CL  3  (detail)  349
(46%)
IV23.1 + 7.2
(-)
41.4 + 15
(-)
423
(49%)
34.2 + 7.7
(-)
Negative
Xu, 2007
China PO  2  (detail)  275
(45%)
IV-43.3 + 11.5
(-)
297
(47%)
43.7 + 12.1
(-)
Negative
Zhou, 2010
China CL  1  (detail)  387
(33%)
IV-50.5 + 9.9
(-)
365
(30%)
49.8 + 9.3
(-)
Negative
 Other/Mixed
Egan, 2003
USA CL  1  (detail)  203
(21%)
U--133
(45%)
-Negative
Gupta, 2009
India CL  1  (detail)  254
(39%)
IV-29.2 + 7.6
(-)
225
(62%)
86 + 31
(-)
Positive
Hashimoto, 2006
USA CL  1  (detail)  27
(-)
U--27
(-)
-Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds    
Study Population # Polys # Families # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Muglia, 2003
Mixed  1  (detail)  8989
(-)
IIIR--188
(47%)
-Positive
Rosa, 2006
Spain  1  (detail)  9494
(22%)
IV-26.8 + 5.8
(-)
282
(51%)
-Positive
Shaikh, 2010
Overlaps with
Dutt, 2009
 1  (detail)   138
(40%)
IV-40.8 + 11.8
(21-65)
109
(53%)
45.9 + 12.8
(19-65)
Negative
Zai, 2010
Canada, USA  4  (detail)  95-IV----Negative
 Other/Mixed
Fanous, 2004
USA  1  (detail)  270595
(-)
IIIR----Trend
Wassink, 1999
USA  1  (detail)  4848
(21%)
M20.1 + 4.4
(-)
-96
(50%)
-Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine SZ diagnosis ->  "IIIR"(DSM-IIIR), "IV" (DSM-IV), "9" (ICD-9), "10" (ICD-10), "M" (Mixed), "RDC" (Research Diagnostic Criteria), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
SZGene Recent Updates
SZGene Stats
Studies: 1727
Genes: 1008
Polymorphisms: 8788
Meta-analyses: 287
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