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Meta-Analysis of All Published SZ Association Studies (Case-Control Only) CHRNA7_-86C/T

Polymorphism:

CHRNA7_-86C/T

Gene:

CHRNA7 (NACHRA7)

View on AlzGene View on PDGene

Protein:

cholinergic receptor, nicotinic, alpha 7 (alpha7 nicotinic receptor subunit; a7 nicotinic acetylcholine receptor; nicotinic cholinergic receptor alpha 7; nicotinic acetylcholine alpha-7 subunit; alpha-7 nicotinic cholinergic receptor subunit; alpha 7 neuronal nicotinic acetylcholine receptor; cholinergic receptor, nicotinic, alpha polypeptide 7; neuronal nicotinic acetylcholine receptor alpha-7 subunit; nicotinic acetylcholine receptor alpha7 subunit precursor)

Chromosome:

15 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 21 October 2010

Polymorphism:

1) Summary of Allele and Genotype Distribution of all Published Association Studies (by Ethnic Group)
			Alleles		Genotypes
	# Case-Control Samples		T-Allele (frequency)	C-Allele (frequency)	T/T (frequency)	T/C (frequency)	C/C (frequency)
Caucasian	2	SZ CTR	0.06 0.06	0.94 0.94	4 (0.005) 2 (0.003)	97 (0.113) 79 (0.112)	760 (0.883) 622 (0.885)
Total	2	SZ CTR	0.06 0.06	0.94 0.94	4 (0.005) 2 (0.003)	97 (0.113) 79 (0.112)	760 (0.883) 622 (0.885)

Meta-Analysis Methods * New * Cumulative Meta-analysis

2) Forest plot for polymorphism CHRNA7_-86C/T

Please also see disclaimer for more information on these meta-analyses.

Meta-analyses have not been performed on the following polymorphisms since they lack published genotype data in at least four independent case-control samples, or the published genotype data was otherwise not eligible for inclusion (see methods for details):

CHRNA7_-1252C/A
CHRNA7_-178Indel (-/G)
CHRNA7_-190Indel
CHRNA7_-190Indel
CHRNA7_-46G/T
CHRNA7_-46G/T
CHRNA7_-86C/T
CHRNA7_-92A/G
CHRNA7_933A/G
CHRNA7_STR (ACTC)
CHRNA7PROM ((Promoter-SNP))
D15S128
D15S1360
D15S144
D15S659
L76630 (2bpSTR)
rs10438342
rs12915265
rs12916879
rs1514246
rs1514252
rs1604265
rs2221223
rs2337506
rs2337980
rs2611605
rs28531779 (-194G/C)
rs3087454
rs3935407
rs4779563
rs4779969
rs6494165
rs6494223
rs7174479
rs7179733
rs7402321
rs8035668
rs868437
rs883473
rs904951
rs904952
rs982574


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SZGene Stats Studies: 1727 Genes: 1008 Polymorphisms: 8788 Meta-analyses: 287





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