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Meta-Analysis of All Published SZ Association Studies (Case-Control Only) rs4680
Back Search Methods Disclaimer Credits
 Polymorphism: rs4680 (Val108/158Met)
 Gene: COMT   Entrez Gene    View on AlzGene   View on MSGene   View on PDGene
 Protein: catechol-O-methyltransferase   ProteinLink
 Chromosome: 22   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 21 October 2010
Gene Overview
 Polymorphism:
1) Summary of Allele and Genotype Distribution of all Published Association Studies (by Ethnic Group)
      Alleles Genotypes
  # Case-Control
Samples
  A-Allele
(frequency)
G-Allele
(frequency)
A/A
(frequency)
A/G
(frequency)
G/G
(frequency)
 Caucasian 34 SZ
CTR
0.49
0.49
0.51
0.51
2271 (0.241)
3147 (0.235)
4594 (0.489)
6775 (0.507)
2539 (0.270)
3442 (0.258)
 Asian 21 SZ
CTR
0.30
0.29
0.71
0.71
468 (0.092)
495 (0.087)
2078 (0.407)
2269 (0.399)
2565 (0.502)
2920 (0.514)
 Other/Mixed 6 SZ
CTR
0.45
0.51
0.55
0.50
223 (0.213)
277 (0.256)
498 (0.475)
537 (0.497)
327 (0.312)
267 (0.247)
Total 61 SZ
CTR
0.42
0.43
0.58
0.57
2962 (0.190)
3919 (0.195)
7170 (0.461)
9581 (0.476)
5431 (0.349)
6629 (0.329)

Meta-Analysis Methods      * New * Cumulative Meta-analysis
2) Forest plot for polymorphism  rs4680 (Val108/158Met)

Please also see disclaimer for more information on these meta-analyses.


Meta-analyses have not been performed on the following polymorphisms since they lack published genotype data in at least four independent case-control samples, or the published genotype data was otherwise not eligible for inclusion (see methods for details):

COMT_-137A/G
COMT_-287A/G
COMT_597G/A
D22S264
D22S446 (BV079565)
D22S447 (BV079566)
D22S451 (BV079567)
D22S688 (BV079568)
D22S705 (BV079569)
D22S873 (BV079570)
D22S944
D22S958 (BV079571)
rs1012157
rs1544325
rs1548357
rs165656
rs165722
rs165728
rs16982844
rs17210001
rs174673
rs174675
rs174682
rs174696
rs174697
rs174699
rs1800706 (HinfI)
rs1805052 (177G/C)
rs2020917
rs2075507 (HindIII)
rs2075507 (rs2097603/HindIII)
rs2075507
rs2097603
rs2238794
rs2238797
rs2239393
rs2240716
rs362204
rs3788310
rs3788319
rs3810595
rs3838146 (820/900)
rs3838146 (820/900)
rs4633 (186C/T)
rs4646310
rs4646312
rs4646315
rs4646317
rs4646318
rs4680 (Val108/158Met)
rs4818 (408/256)
rs4818 (136C/G)
rs5746849
rs5992500
rs5993882
rs5993883
rs6269
rs6518592
rs71186636 (T-repeat)
rs7289747
rs7290221
rs737864
rs737866
rs740601
rs8185002
rs885987
rs9332347
rs9332362
rs9332377
rs9332381
rs933271

SZGene Recent Updates
SZGene Stats
Studies: 1727
Genes: 1008
Polymorphisms: 8788
Meta-analyses: 287
ALSGene
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An up-to-date collection of all published genetic association studies.
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