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Polymorphism Details     
Back Search Methods Disclaimer Credits
 Study: Jungerius, 2007
 Gene: NRG1  (GGF; HGL; HRG; NDF; ARIA; GGF2; HRG1; HRGA; SMDF)  Entrez Gene    View on AlzGene
 Protein: neuregulin 1  (glial growth factor; neu differentiation factor; sensory and motor neuron derived factor; heregulin, alpha (45kD, ERBB2 p185-activator))  ProteinLink
 Chromosome: 8   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 23 November 2010
Meta-Analysis     Gene Overview
Total number of polymorphisms investigated by this study: 17

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   T-Allele C-Allele T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
 Caucasian
rs7819063 Netherlands SZ
CTR
0.23
0.23
0.77
0.77
16 (0.052)
27 (0.052)
109 (0.355)
182 (0.351)
182 (0.593)
310 (0.597)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   G-Allele T-Allele G/G
(frequency)
G/T
(frequency)
T/T
(frequency)
 Caucasian
rs7007436 Netherlands SZ
CTR
0.31
0.29
0.69
0.71
30 (0.097)
45 (0.087)
133 (0.430)
216 (0.416)
146 (0.472)
258 (0.497)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   m-Allele M-Allele m/m
(frequency)
m/M
(frequency)
M/M
(frequency)
 Caucasian
rs4452759 Netherlands SZ
CTR
0.51
0.47
0.49
0.53
81 (0.263)
114 (0.221)
154 (0.500)
258 (0.499)
73 (0.237)
145 (0.280)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
rs10503929 Netherlands SZ
CTR
0.17
0.20
0.83
0.80
9 (0.029)
20 (0.038)
86 (0.277)
164 (0.315)
216 (0.695)
336 (0.646)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   G-Allele C-Allele G/G
(frequency)
G/C
(frequency)
C/C
(frequency)
 Caucasian
rs4733132 Netherlands SZ
CTR
0.26
0.27
0.74
0.73
21 (0.068)
39 (0.075)
119 (0.384)
207 (0.399)
170 (0.548)
273 (0.526)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
rs2466059 Netherlands SZ
CTR
0.10
0.11
0.90
0.89
3 (0.010)
6 (0.012)
58 (0.188)
97 (0.187)
247 (0.802)
415 (0.801)


Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)
Population   G-Allele A-Allele G/G
(frequency)
G/A
(frequency)
A/A
(frequency)
 Caucasian
rs4733130 Netherlands SZ
CTR
0.47
0.50
0.53
0.50
67 (0.217)
130 (0.250)
154 (0.498)
260 (0.500)
88 (0.285)
130 (0.250)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)
Population   G-Allele A-Allele G/G
(frequency)
G/A
(frequency)
A/A
(frequency)
 Caucasian
rs7005288 Netherlands SZ
CTR
0.21
0.20
0.79
0.80
14 (0.045)
20 (0.038)
104 (0.337)
163 (0.313)
191 (0.618)
337 (0.648)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
rs2976532 Netherlands SZ
CTR
0.52
0.50
0.48
0.50
83 (0.267)
128 (0.246)
155 (0.498)
260 (0.499)
73 (0.235)
133 (0.255)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
rs4236710 Netherlands SZ
CTR
0.42
0.40
0.58
0.60
55 (0.177)
84 (0.162)
151 (0.486)
250 (0.481)
105 (0.338)
186 (0.358)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)
Population   A-Allele G-Allele A/A
(frequency)
A/G
(frequency)
G/G
(frequency)
 Caucasian
rs12547858 Netherlands SZ
CTR
0.19
0.21
0.81
0.79
12 (0.039)
22 (0.042)
97 (0.312)
171 (0.329)
202 (0.650)
327 (0.629)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele G-Allele C/C
(frequency)
C/G
(frequency)
G/G
(frequency)
 Caucasian
rs10954864 Netherlands SZ
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)
Population   A-Allele G-Allele A/A
(frequency)
A/G
(frequency)
G/G
(frequency)
 Caucasian
rs4281084 Netherlands SZ
CTR
0.25
0.24
0.75
0.76
20 (0.064)
31 (0.060)
117 (0.376)
191 (0.368)
174 (0.559)
297 (0.572)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)
Population   C-Allele A-Allele C/C
(frequency)
C/A
(frequency)
A/A
(frequency)
 Caucasian
rs10954809 Netherlands SZ
CTR
0.47
0.48
0.53
0.52
68 (0.221)
119 (0.229)
153 (0.498)
259 (0.499)
86 (0.280)
141 (0.272)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)
Population   T-Allele A-Allele T/T
(frequency)
T/A
(frequency)
A/A
(frequency)
 Caucasian
rs6996203 Netherlands SZ
CTR
0.09
0.09
0.91
0.91
2 (0.006)
4 (0.008)
50 (0.162)
86 (0.166)
257 (0.832)
427 (0.826)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)
Population   T-Allele C-Allele T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
 Caucasian
rs2466064 Netherlands SZ
CTR
0.32
0.32
0.68
0.68
32 (0.104)
52 (0.101)
135 (0.437)
224 (0.435)
142 (0.460)
239 (0.464)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   G-Allele C-Allele G/G
(frequency)
G/C
(frequency)
C/C
(frequency)
 Caucasian
rs10098373 Netherlands SZ
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).
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Genes: 1008
Polymorphisms: 8788
Meta-analyses: 287
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