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Polymorphism Details     
Back Search Methods Disclaimer Credits
 Study: Weickert, 2008
 Gene: ESR1  (ER; ESR; Era; ESRA; NR3A1)  Entrez Gene    View on AlzGene   View on MSGene   View on PDGene
 Protein: estrogen receptor 1  (oestrogen receptor; steroid hormone receptor)  ProteinLink
 Chromosome: 6   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 9 August 2010
Meta-Analysis     Gene Overview
Total number of polymorphisms investigated by this study: 12

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 African Descent
rs488133 USA (NIMH) SZ
CTR		 0.09
0.09		 0.91
0.91		 2 (0.050)
2 (0.024)		 3 (0.075)
10 (0.122)		 35 (0.875)
70 (0.854)
 Caucasian
rs488133 USA (NIMH) SZ
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele T-Allele G/G
(frequency)		 G/T
(frequency)		 T/T
(frequency)
 African Descent
rs2071454 USA (NIMH) SZ
CTR		 0.38
0.38		 0.62
0.62		 6 (0.133)
16 (0.186)		 22 (0.489)
34 (0.395)		 17 (0.378)
36 (0.419)
 Caucasian
rs2071454 USA (NIMH) SZ
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele C-Allele G/G
(frequency)		 G/C
(frequency)		 C/C
(frequency)
 African Descent
rs1801132 USA (NIMH) SZ
CTR		 0.07
0.12		 0.93
0.88		 0 (0.000)
3 (0.035)		 6 (0.136)
15 (0.174)		 38 (0.864)
68 (0.791)
 Caucasian
rs1801132 USA (NIMH) SZ
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 African Descent
rs932477 USA (NIMH) SZ
CTR		 0.11
0.12		 0.89
0.88		 0 (0.000)
1 (0.012)		 10 (0.222)
19 (0.221)		 35 (0.778)
66 (0.767)
 Caucasian
rs932477 USA (NIMH) SZ
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 African Descent
ESR1_SNP-C1 USA (NIMH) SZ
CTR		 0.08
0.04		 0.92
0.96		 2 (0.051)
0 (0.000)		 2 (0.051)
6 (0.082)		 35 (0.897)
67 (0.918)
 Caucasian
ESR1_SNP-C1 USA (NIMH) SZ
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 African Descent
rs9478245 USA (NIMH) SZ
CTR		 0.20
0.12		 0.80
0.88		 2 (0.050)
0 (0.000)		 12 (0.300)
20 (0.238)		 26 (0.650)
64 (0.762)
 Caucasian
rs9478245 USA (NIMH) SZ
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 African Descent
rs2234693 (PvuII) USA (NIMH) SZ
CTR		 0.46
0.46		 0.54
0.54		 13 (0.317)
16 (0.184)		 12 (0.293)
48 (0.552)		 16 (0.390)
23 (0.264)
 Caucasian
rs2234693 (PvuII) USA (NIMH) SZ
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele G-Allele T/T
(frequency)		 T/G
(frequency)		 G/G
(frequency)
 African Descent
rs2273206 USA (NIMH) SZ
CTR		 0.39
0.36		 0.61
0.64		 7 (0.171)
10 (0.120)		 18 (0.439)
39 (0.470)		 16 (0.390)
34 (0.410)
 Caucasian
rs2273206 USA (NIMH) SZ
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 African Descent
rs2273207 USA (NIMH) SZ
CTR		 0.04
0.10		 0.96
0.90		 0 (0.000)
1 (0.012)		 4 (0.089)
15 (0.174)		 41 (0.911)
70 (0.814)
 Caucasian
rs2273207 USA (NIMH) SZ
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 African Descent
ESR1_SNP-C24 USA (NIMH) SZ
CTR		 0.04
0.10		 0.96
0.90		 0 (0.000)
1 (0.012)		 4 (0.089)
15 (0.174)		 41 (0.911)
70 (0.814)
 Caucasian
ESR1_SNP-C24 USA (NIMH) SZ
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)


Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 African Descent
rs488133 USA (NIMHGI) SZ
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Caucasian
rs488133 USA (NIMH) SZ
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele T-Allele G/G
(frequency)		 G/T
(frequency)		 T/T
(frequency)
 African Descent
rs2071454 USA (NIMHGI) SZ
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Caucasian
rs2071454 USA (NIMH) SZ
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele C-Allele G/G
(frequency)		 G/C
(frequency)		 C/C
(frequency)
 African Descent
rs1801132 USA (NIMHGI) SZ
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Caucasian
rs1801132 USA (NIMH) SZ
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 African Descent
rs932477 USA (NIMHGI) SZ
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Caucasian
rs932477 USA (NIMH) SZ
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   del-Allele ins-Allele del/del
(frequency)		 del/ins
(frequency)		 ins/ins
(frequency)
 African Descent
rs35903830 (Indel) USA (NIMHGI) SZ
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Caucasian
rs35903830 (Indel) USA (NIMH) SZ
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 African Descent
ESR1_SNP-C1 USA (NIMHGI) SZ
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 African Descent
rs9478245 USA (NIMHGI) SZ
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Caucasian
rs9478245 USA (NIMH) SZ
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 African Descent
rs2234693 (PvuII) USA (NIMHGI) SZ
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Caucasian
rs2234693 (PvuII) USA (NIMH) SZ
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele G-Allele T/T
(frequency)		 T/G
(frequency)		 G/G
(frequency)
 African Descent
rs2273206 USA (NIMHGI) SZ
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Caucasian
rs2273206 USA (NIMH) SZ
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 African Descent
rs2273207 USA (NIMHGI) SZ
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Caucasian
rs2273207 USA (NIMH) SZ
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 African Descent
ESR1_SNP-C24 USA (NIMHGI) SZ
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Caucasian
ESR1_SNP-C24 USA (NIMH) SZ
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 African Descent
ESR1_C1 USA (NIMHGI) SZ
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Caucasian
ESR1_C1 USA (NIMH) SZ
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).
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