Schizophrenia Research Forum - A Catalyst for Creative Thinking
Home Your Profile Become a Member/Get Newsletter Contact Us
What's New
Recent Updates
SRF Papers
Current Papers
Search All Papers
Search Comments
News
Research News
Forums
Current Hypotheses
Idea Lab
Online Discussions
Virtual Conferences
Interviews
Tech Corner
Resources
What We Know
SchizophreniaGene
Animal Models
Drugs in Trials
Research Tools
Grants
Jobs
Conferences
Journals
Community Calendar
General Information
Community
Member Directory
Researcher Profiles
Institutes and Labs
About the Site
Mission
History
SRF Team
Advisory Board
Support Us
How to Cite
Fan (E)Mail
The Schizophrenia Research Forum web site is sponsored by NARSAD, the Brain and Behavior Research Fund, and was created with funding from the U.S. National Institute of Mental Health.
Printable version  
SZGene - Gene overview of all published SZ-association studies for TH    
Back Search Methods Disclaimer Credits
 Gene: TH  (TYH)  Entrez Gene    View on PDGene
 Protein: tyrosine hydroxylase   ProteinLink
 Chromosome: 11   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 22 October 2010
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      SZ Cases Normal Controls    
Study Population Source # Polys # Subjects
(% women)		 DX Onset Age
(range)		 Age
(range)		 # Subjects
(% women)		 Age
(range)		 Result Comment
 Caucasian
Andreou, 2009
 Sweden CL  1  (detail)  834
(42%)		M-45.7 + 14.3
(-)		1471
(42%)		44.1 + 8
(-)		Negative
Burgert, 1998
 France CL  1  (detail)  107
(-)		IV--76
(-)		25
(-)		Negative
Hoogendoorn, 2005
 Netherlands CL  1  (detail)  208
(-)		IV--288
(-)		-Negative
Jonsson, 1996
 Sweden CL  1  (detail)  118
(36%)		IIIR-45.8
(20-90)		78
(42%)		38.7
(29-56)		Negative
Jonsson, 1998
 Overlaps with
Jonsson, 1996		 CL  1  (detail)  117
(-)		IIIR--76
(-)		-n.a.
Meloni, 1995
 France CL  1  (detail)  94
(34%)		IIIR-42 + 12.3
(-)		145
(42%)		48 + 8.3
(-)		Positive
Meloni, 1995
 Tunisia CL  1  (detail)  44
(25%)		IIIR-37 + 8.2
(-)		44
(16%)		35 + 5.9
(-)		Positive
Pal, 2009
 Croatia CL  2  (detail)  103
(42%)		10-43.6 + 10.6
(23-74)		131
(-)		50.3 + 7.5
(30-74)		Positive
Talkowski, 2008
 USA CL  3  (detail)  328
(-)		IV--501
(-)		-Negative
Wei, 1995
 UK CL  1  (detail)  176
(34%)		U-36.1 + 10.4
(-)		107
(46%)		38.9 + 13.4
(-)		Positive
 African Descent
Chao, 2002
 USA CL  1  (detail)  41
(-)		IIIR--17
(-)		-n.a.
 Asian
Ishiguro, 1998
 Japan CL  3  (detail)  208
(44%)		IV22.4
(12-39)		47.2
(19-81)		266
(45%)		48.3
(29-75)		Negative
Iwata, 2003
 Japan CL  1  (detail)  51
(57%)		IV13.5 + 1.7
(9-16)		20 + 7
(-)		148
(56%)		21 + 7
(-)		Negative
Kunugi, 1998
 Japan CL  1  (detail)  194
(47%)		IV--161
(50%)		-Negative
Kurumaji, 2001
 Japan CL  1  (detail)  291
(42%)		IV-43.8 + 12
(-)		339
(46%)		46.3 + 12.3
(-)		Positive
Ota, 2001
 Japan CL  1  (detail)  201
(51%)		IV-47.8 + 12.7
(-)		175
(59%)		47.1 + 11
(-)		Negative
Pae, 2003
 Korea CL  1  (detail)  334
(51%)		IV-30.8 + 9.7
(-)		391
(46%)		35.2 + 14.4
(-)		Negative
 Other/Mixed
Srivastava, 2010
 India CL  2  (detail)  215
(48%)		IV21.4 + 6.1
(-)		29.3 + 8.9
(-)		215
(40%)		34.6 + 12.4
(-)		Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds    
Study Population # Polys # Families # Subjects
(% women)		 DX Onset Age
(range)		 Age
(range)		 # Subjects
(% women)		 Age
(range)		 Result Comment
 Caucasian
Talkowski, 2008
 USA  3  (detail)  150150
(50%)		IV--300
(50%)		-Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine SZ diagnosis ->  "IIIR"(DSM-IIIR), "IV" (DSM-IV), "9" (ICD-9), "10" (ICD-10), "M" (Mixed), "RDC" (Research Diagnostic Criteria), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
SZGene Recent Updates
SZGene Stats
Studies: 1727
Genes: 1008
Polymorphisms: 8788
Meta-analyses: 287
ALSGene
AlzGene
MSGene
PDGene
SZGene
An up-to-date collection of all published genetic association studies.
SRF News
SRF Comments
Text Size
Reset Text Size
Email this pageEmail this page

Share/Bookmark
Research Participants
Collaborators
Copyright © 2005-2024 Schizophrenia Research Forum Privacy Policy Disclaimer Disclosure Copyright