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SZGene - Gene overview of all published SZ-association studies for TPH1    
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 Gene: TPH1  (TPH; TPRH)  Entrez Gene    View on AlzGene
 Protein: tryptophan hydroxylase 1  (tryptophan 5-monooxygenase)  ProteinLink
 Chromosome: 11   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 22 October 2010
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      SZ Cases Normal Controls    
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Anttila, 2007
Finland CL  1  (detail)  94
(51%)
IV30 + 9.9
(-)
45.9 + 10.9
(-)
392
(46%)
44.4 + 11.1
(-)
Positive
Betcheva, 2009
Bulgaria CL  3  (detail)  185
(-)
IV--184
(-)
-Negative
Chotai, 2003
Overlaps with
Serretti, 2001
CL  1  (detail)  147
(-)
IV22 + 5
(-)
36 + 9
(-)
395
(46%)
54 + 13
(-)
n.a.
Chotai, 2005
Overlaps with
Serretti, 2001
CL  1  (detail)  114
(24%)
IV22 + 5
(-)
36 + 9
(-)
241
(42%)
54 + 13
(-)
n.a.
Saetre, 2009
Denmark, Norway, Sweden CL  5  (detail)  837
(42%)
M27
(-)
45.7
(-)
1473
(42%)
44.1
(-)
Positive
Serretti, 2001
Italy CL  1  (detail)  210
(-)
IV--380
(50%)
46.4 + 13.6
(-)
Negative
Zaboli, 2006
Overlaps with
Saetre, 2009
CL  6  (detail)  155
(39%)
IIIR24.2 + 7.3
(-)
43.8 + 16.5
(-)
253
(39%)
42.6 + 13.7
(-)
Positive
 African Descent
Chao, 2002
USA CL  2  (detail)  41
(76%)
IIIR-50.5
(-)
17
(88%)
67.1
(-)
n.a.
 Asian
Hokyo, 2010
Japan CL  1  (detail)  407
(42%)
IV-54.7
(-)
384
(64%)
40.1
(-)
Negative
Hong, 2001
Taiwan CL  1  (detail)  196
(54%)
IV-35.3 + 12.1
(-)
251
(51%)
33.8 + 7.4
(-)
Positive
Kim, 2010
Korea CL  1  (detail)  165
(42%)
IV24.5
(-)
38.4
(-)
335
(39%)
24.5 + 5.7
(19-57)
Negative
Liu, 2006
China CL  5  (detail)  626
(38%)
IIIR-44.6
(-)
184
(47%)
42.8 + 14.4
(-)
Positive
Paik, 2000
Korea CL  1  (detail)  217
(49%)
IIIR-30 + 9
(-)
236
(47%)
29.6 + 3.7
(-)
Negative
Sekizawa, 2004
Japan CL  1  (detail)  51
(57%)
IV-20 + 7
(-)
148
(56%)
21 + 7
(-)
Positive
Shinkai, 2000
Japan CL  2  (detail)  182
(53%)
IV-53.9 + 11
(-)
148
(49%)
55.5 + 6.8
(-)
Negative
Shiroiwa, 2010
Japan CL  1  (detail)  343
(54%)
IV-52.7
(-)
377
(57%)
42.7
(-)
Negative
Watanabe, 2007
Japan CL  6  (detail)  409
(46%)
IV22 + 6.2
(-)
40.5 + 14.7
(-)
440
(48%)
38.2 + 10.4
(-)
Negative
 Other/Mixed
Semwal, 2002
India CL  2  (detail)  536
(44%)
IV-22.8 + 7
(-)
936
(47%)
32.9 + 12.7
(-)
Positive
Viana, 2006
Brazil CL  1  (detail)  104
(-)
IV--63
(43%)
34.3 + 8.9
(-)
Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds    
Study Population # Polys # Families # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Asian
Semwal, 2001
Overlaps with
Semwal, 2002
 2  (detail)  179179
(42%)
IV22.1 + 6.3
(-)
---n.a.
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine SZ diagnosis ->  "IIIR"(DSM-IIIR), "IV" (DSM-IV), "9" (ICD-9), "10" (ICD-10), "M" (Mixed), "RDC" (Research Diagnostic Criteria), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
SZGene Recent Updates
SZGene Stats
Studies: 1727
Genes: 1008
Polymorphisms: 8788
Meta-analyses: 287
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An up-to-date collection of all published genetic association studies.
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