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Printable version
SZGene - Gene overview of all published SZ-association studies for SLC6A4
Gene:
SLC6A4
(HTT; 5HTT; OCD1; SERT; 5-HTT; hSERT)
View on AlzGene
View on PDGene
Protein:
solute carrier family 6 member 4
(5HT transporter; serotonin transporter; 5-hydroxytryptamine transporter; sodium-dependent serotonin transporter; Na+/Cl- dependent serotonin transporter)
Chromosome:
17
(View:
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
X
Y
MT
)
Status:
Updated 22 October 2010
1. Case-Control Studies (by ethnic group)
SZ Cases
Normal Controls
Study
Population
Source
# Polys
# Subjects
(% women)
DX
Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
Comment
Caucasian
Bayle, 2003
France
CL
1
(detail)
185
(30%)
IV
-
32 + 9
(-)
159
(35%)
35 + 10
(-)
Negative
Bonnet-Brilhault, 1997
France
CL
1
(detail)
105
(30%)
IIIR
-
-
114
(48%)
-
Negative
Chotai, 2005
Overlaps with
Serretti, 2002
CL
1
(detail)
114
(24%)
IV
22 + 5
(-)
36 + 9
(-)
241
(42%)
54 + 13
(-)
n.a.
Collier, 1996
UK
CL
1
(detail)
129
(-)
IIIR
-
-
187
(-)
-
Trend
Dutt, 2009
UK, Ireland
CL
1
(detail)
83
(-)
IV
-
-
57
(-)
-
Negative
Golimbet, 2003
Russia
CL
2
(detail)
110
(43%)
10
23.7 + 5.8
(-)
25.3 + 6.7
(-)
124
(63%)
31.6 + 13.5
(-)
Negative
Herken, 2002
Turkey
CL
1
(detail)
128
(-)
IV
-
-
135
(-)
-
Negative
Herken, 2003a
Turkey
CL
2
(detail)
143
(35%)
IV
-
32.3 + 9.1
(-)
79
(-)
-
Negative
Kaiser, 2001
Germany
CL
2
(detail)
684
(47%)
IV
27 + 9.3
(12-66)
38.5 + 12.1
(18-70)
587
(22%)
30.1 + 7.6
(18-58)
Trend
Kotler, 1999
Israel
CL
1
(detail)
92
(37%)
10
-
-
415
(62%)
28 + 15
(-)
Negative
Mata, 2004
Spain
CL
2
(detail)
200
(-)
IV
-
-
334
(47%)
26.8 + 5.4
(-)
Negative
Meda, 2009
USA
CL
2
(detail)
31
(-)
IV
-
-
35
(-)
-
Negative
Mendes de Oliveira, 1998
Brazil
CL
1
(detail)
39
(-)
IV
-
-
98
(-)
-
Negative
Naylor, 1998
Australia
CL
1
(detail)
58
(-)
IIIR
-
-
62
(-)
-
Negative
Pal, 2009
Croatia
CL
4
(detail)
103
(42%)
10
-
43.6 + 10.6
(23-74)
131
(-)
50.3 + 7.5
(30-74)
Positive
Rao, 1998
USA
CL
1
(detail)
80
(40%)
IV
-
37.4 + 10
(-)
127
(66%)
30 + 10.3
(-)
Negative
Rao, 1998
Overlaps with
Zaboli, 2007
CL
1
(detail)
122
(35%)
IIIR
-
45 + 17.3
(-)
99
(34%)
38.2 + 6.3
(-)
n.a.
Saiz, 2007
Spain
CL
2
(detail)
227
(40%)
IV
-
35.7 + 11.7
(-)
420
(49%)
40.6 + 11.3
(-)
Negative
Sanjuan, 2006
Spain
CL
1
(detail)
158
(31%)
IV
-
38.4 + 11.6
(-)
138
(-)
-
Positive
Serretti, 2002
Italy
CL
1
(detail)
261
(-)
IV
-
-
457
(51%)
46 + 15.5
(-)
Negative
Stober, 1998
Germany
CL
2
(detail)
180
(38%)
10
26.5 + 9.7
(-)
-
233
(41%)
29.9 + 10
(-)
Negative
Zaboli, 2007
Sweden
CL
4
(detail)
155
(40%)
M
24.2 + 7.3
(-)
43.8 + 16.5
(-)
246
(39%)
41 + 11.2
(-)
Positive
African Descent
Rao, 1998
USA
CL
1
(detail)
47
(43%)
IV
-
35.2 + 9.3
(-)
37
(57%)
30 + 8
(-)
Negative
Asian
Chong, 2000
China
CL
1
(detail)
338
(36%)
IV
-
-
103
(-)
-
Negative
Han, 2004
Korea
CL
1
(detail)
168
(0%)
IV
-
-
158
(0%)
-
Negative
Ikeda, 2006
Japan
CL
6
(detail)
287
(48%)
IV
-
42.3 + 14.7
(-)
288
(48%)
33.6 + 12.9
(-)
Negative
Lee, 2009
Korea
CL
2
(detail)
141
(57%)
IV
-
34 + 10.7
(-)
115
(47%)
33.5 + 10.3
(-)
Negative
Lin, 2009
China
PO
4
(detail)
329
(38%)
IV
-
49.5 + 11.4
(-)
288
(45%)
37 + 8.1
(-)
Positive
Liu, 1999
China
CL
1
(detail)
255
(42%)
IIIR
-
42 + 15.3
(-)
362
(45%)
42 + 10.2
(-)
Positive
Pae, 2003
Korea
CL
1
(detail)
111
(52%)
IV
24.7
(-)
30.3 + 9.4
(-)
208
(45%)
23.8 + 4.3
(-)
Negative
Pae, 2005
Overlaps with
Pae, 2003
CL
1
(detail)
111
(52%)
IV
-
30.3 + 9.4
(-)
172
(53%)
25 + 9.9
(-)
n.a.
Pae, 2006
Korea
CL
1
(detail)
152
(52%)
IV
-
26.9 + 11.6
(-)
152
(55%)
32 + 10.7
(-)
Negative
Tsai, 2000
China
CL
1
(detail)
90
(34%)
IV
-
37.1 + 0.9
(-)
104
(72%)
49.6 + 0.8
(-)
Negative
Tsai, 2002
Taiwan
CL
1
(detail)
114
(59%)
IIIR
-
44.5 + 11.1
(-)
127
(65%)
42.8 + 9.2
(-)
Positive
Other/Mixed
Konneker, 2010
USA
CL
2
(detail)
738
(26%)
IV
-
-
733
(33%)
-
Negative
Vijayan, 2009
India
CL
5
(detail)
243
(66%)
IV
-
33 + 11
(-)
243
(-)
31.7 + 6.9
(-)
Positive
Young, 2006
USA
CL
1
(detail)
12
(-)
U
-
-
15
(-)
-
Negative
Contact us
if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
Affecteds
Unaffecteds
Study
Population
# Polys
# Families
# Subjects
(% women)
DX
Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
Comment
Caucasian
Dimitrova, 2002
Bulgaria
1
(detail)
266
-
IIIR
-
-
-
-
Negative
Dubertret, 2005
France
2
(detail)
103
103
(21%)
IV
20.8 + 8.1
(-)
31.4 + 7.7
(-)
206
(50%)
59.8 + 7.8
(-)
Positive
Hranilovic, 2000
Germany, Israel
2
(detail)
61
139
(-)
IIIR
-
-
266
(50%)
-
Positive
Contact us
if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:
Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:
Number of polymorphisms tested per gene and per sample.
Onset Age and Age:
Mean or median age at onset or examination, respectively.
DX:
Criteria used to determine SZ diagnosis -> "IIIR"(DSM-IIIR), "IV" (DSM-IV), "9" (ICD-9), "10" (ICD-10), "M" (Mixed), "RDC" (Research Diagnostic Criteria), "U" (Unknown).
Result:
Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-)
: Either no data provided or in case of overlap, data included in original study.
SZGene Recent Updates
SZGene Stats
Studies: 1727
Genes: 1008
Polymorphisms: 8788
Meta-analyses: 287
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