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SZGene - Gene overview of all published SZ-association studies for NOS1AP    
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 Gene: NOS1AP  (CAPON)  Entrez Gene
 Protein: nitric oxide synthase 1 (neuronal) adaptor protein  (C-terminal PDZ domain ligand of neuronal nitric oxide synthase)  ProteinLink
 Chromosome: 1   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 3 October 2010
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      SZ Cases Normal Controls    
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Betcheva, 2009
Bulgaria CL  1  (detail)  185
(-)
IV--184
(-)
-Negative
Delorme, 2010
France CL  11  (detail)  297
(-)
IV--286
(-)
-Negative
Puri, 2006a
UK CL  8  (detail)  450
(30%)
10-44.8
(-)
450
(54%)
36.5
(-)
Negative
Puri, 2006b
Overlaps with
Puri, 2006a
CL  8  (detail)  450
(-)
10--450
(-)
-n.a.
 Asian
Zheng, 2005
China CL  9  (detail)  664
(45%)
IIIR25 + 10.2
(-)
46.5 + 14.7
(-)
941
(46%)
33.6 + 9.5
(-)
Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds    
Study Population # Polys # Families # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Brzustowicz, 2004
Overlaps with
Wratten, 2009
 19  (detail)  2485
(-)
IIIR--232
(-)
-Positive
Wratten, 2009
Canada  60  (detail)  2485
(-)
M--232
(-)
-Positive
 Asian
Fang, 2008
China  5  (detail)  319319
(45%)
IV-24 + 6.6
(-)
638
(50%)
-Negative
 Hispanic
Kremeyer, 2009
Colombia  22  (detail)   102
(23%)
IV21 + 7.2
(-)
34.3 + 10.2
(-)
--Positive
 Other/Mixed
Miranda, 2006
Colombia  1  (detail)  110-IV----Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine SZ diagnosis ->  "IIIR"(DSM-IIIR), "IV" (DSM-IV), "9" (ICD-9), "10" (ICD-10), "M" (Mixed), "RDC" (Research Diagnostic Criteria), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
SZGene Recent Updates
SZGene Stats
Studies: 1727
Genes: 1008
Polymorphisms: 8788
Meta-analyses: 287
ALSGene
AlzGene
MSGene
PDGene
SZGene
An up-to-date collection of all published genetic association studies.
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