SZGene

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SZGene - Gene overview of all published SZ-association studies for NOS1AP

Gene:

NOS1AP (CAPON)

Protein:

nitric oxide synthase 1 (neuronal) adaptor protein (C-terminal PDZ domain ligand of neuronal nitric oxide synthase)

Chromosome:

1 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 3 October 2010

1. Case-Control Studies (by ethnic group)
				SZ Cases				Normal Controls
Study	Population	Source	# Polys	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result	Comment
Caucasian
Betcheva, 2009	Bulgaria	CL	1 (detail)	185 (-)	IV	-	-	184 (-)	-	Negative
Delorme, 2010	France	CL	11 (detail)	297 (-)	IV	-	-	286 (-)	-	Negative
Puri, 2006a	UK	CL	8 (detail)	450 (30%)	10	-	44.8 (-)	450 (54%)	36.5 (-)	Negative
Puri, 2006b	Overlaps with Puri, 2006a	CL	8 (detail)	450 (-)	10	-	-	450 (-)	-	n.a.
Asian
Zheng, 2005	China	CL	9 (detail)	664 (45%)	IIIR	25 + 10.2 (-)	46.5 + 14.7 (-)	941 (46%)	33.6 + 9.5 (-)	Positive

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

2. Family-Based Studies (by ethnic group)
				Affecteds				Unaffecteds
Study	Population	# Polys	# Families	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result	Comment
Caucasian
Brzustowicz, 2004	Overlaps with Wratten, 2009	19 (detail)	24	85 (-)	IIIR	-	-	232 (-)	-	Positive
Wratten, 2009	Canada	60 (detail)	24	85 (-)	M	-	-	232 (-)	-	Positive
Asian
Fang, 2008	China	5 (detail)	319	319 (45%)	IV	-	24 + 6.6 (-)	638 (50%)	-	Negative
Hispanic
Kremeyer, 2009	Colombia	22 (detail)		102 (23%)	IV	21 + 7.2 (-)	34.3 + 10.2 (-)	-	-	Positive
Other/Mixed
Miranda, 2006	Colombia	1 (detail)	110	-	IV	-	-	-	-	Positive

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine SZ diagnosis -> "IIIR"(DSM-IIIR), "IV" (DSM-IV), "9" (ICD-9), "10" (ICD-10), "M" (Mixed), "RDC" (Research Diagnostic Criteria), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.


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SZGene Stats Studies: 1727 Genes: 1008 Polymorphisms: 8788 Meta-analyses: 287





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