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Printable version
SZGene - Gene overview of all published SZ-association studies for PLA2G4A
Gene:
PLA2G4A
(PLA2G4; cPLA2-alpha)
Protein:
cytosolic phospholipase A2, group IVA
(lysophospholipase; phosphatidylcholine 2-acylhydrolase; calcium-dependent phospholipid-binding protein)
Chromosome:
1
(View:
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
X
Y
MT
)
Status:
Updated 22 October 2010
1. Case-Control Studies (by ethnic group)
SZ Cases
Normal Controls
Study
Population
Source
# Polys
# Subjects
(% women)
DX
Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
Comment
Caucasian
Barbosa, 2007
Overlaps with
Junqueira, 2004
CL
1
(detail)
75
(57%)
IV
-
-
68
(53%)
-
n.a.
Chowdari, 2001
USA (I)
CL
2
(detail)
74
(46%)
IV
-
36 + 8.6
(21-62)
74
(-)
-
Negative
Doris, 1998
UK
CL
1
(detail)
40
(-)
IV
-
37
(21-63)
40
(-)
35
(22-63)
Negative
Hudson, 1996a
Overlaps with
Hudson, 1996b
CL
1
(detail)
65
(-)
IIIR
-
-
65
(68%)
-
Positive
Hudson, 1996b
USA, Canada
CL
1
(detail)
65
(-)
IIIR
-
-
65
(-)
-
Positive
Nadalin, 2008
Croatia
CL
1
(detail)
81
(47%)
IV
26.1 + 7.2
(-)
39.1 + 10.5
(-)
182
(54%)
-
Negative
Price, 1997
UK
CL
1
(detail)
58
(36%)
IIIR
-
46
(26-83)
56
(43%)
70
(-)
Negative
Wei, 1998
UK
CL
1
(detail)
193
(33%)
U
-
36.1 + 10.5
(-)
101
(49%)
38.9 + 12.6
(-)
Negative
African Descent
Chowdari, 2001
USA (II)
CL
2
(detail)
20
(170%)
IV
-
36 + 8.6
(21-62)
20
(-)
-
Negative
Asian
Li, 2007
China
CL
1
(detail)
498
(-)
10
-
-
299
(-)
-
Negative
Pae, 2004
Korea
CL
1
(detail)
97
(55%)
IV
26.4 + 7.1
(-)
31.5 + 10
(-)
117
(53%)
33 + 11.1
(-)
Positive
Other/Mixed
Junqueira, 2004
Brazil
CL
1
(detail)
240
(43%)
IIIR
-
34 + 8.6
(-)
312
(52%)
35.5 + 9.9
(-)
Negative
Peet, 1998
India
CL
1
(detail)
36
(-)
IV
-
-
27
(-)
-
Positive
Semwal, 2002
India
CL
1
(detail)
536
(44%)
IV
-
22.8 + 7
(-)
936
(47%)
32.9 + 12.7
(-)
Negative
Contact us
if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
Affecteds
Unaffecteds
Study
Population
# Polys
# Families
# Subjects
(% women)
DX
Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
Comment
Caucasian
Hudson, 1996a
Italy, Canada
1
(detail)
44
44
(-)
IIIR
-
-
88
(50%)
-
Positive
Hudson, 1996b
Italy, Canada
1
(detail)
37
37
(-)
IIIR
-
-
72
(-)
-
Positive
Mathur, 2009
UK
1
(detail)
221
222
(28%)
M
-
30.5 + 7.9
(-)
352
(58%)
-
Trend
Wei, 1998
Overlaps with
Mathur, 2009
1
(detail)
50
50
(-)
U
-
-
100
(-)
-
n.a.
Wei, 2004
Overlaps with
Mathur, 2009
3
(detail)
118
118
(31%)
U
-
29 + 6.9
(-)
236
(50%)
-
Positive
Wei, 2005
Overlaps with
Mathur, 2009
1
(detail)
131
131
(30%)
U
-
29.1 + 7.1
(-)
262
(50%)
-
n.a.
Asian
Tao, 2005a
China
1
(detail)
240
240
(36%)
10
-
25.9 + 6.7
(-)
480
(50%)
-
Trend
Tao, 2005b
Overlaps with
Tao, 2005a
1
(detail)
236
236
(35%)
10
-
25.8 + 6.7
(-)
472
(50%)
-
n.a.
Yu, 2004
China
2
(detail)
168
168
(39%)
10
-
-
336
(50%)
-
Negative
Other/Mixed
Chowdari, 2001
USA
2
(detail)
86
86
(40%)
IV
-
36 + 8.6
(21-62)
130
(-)
-
Negative
Chowdari, 2001
Overlaps with
Semwal, 2002
1
(detail)
159
159
(40%)
IV
-
33.3 + 9.2
(16-59)
283
(-)
-
n.a.
Chowdari, 2001
India
1
(detail)
159
159
(40%)
IV
-
33.3 + 9.2
(16-59)
283
(-)
-
Negative
Frieboes, 2001
Europe, China
1
(detail)
328
(36%)
IIIR
-
28.4 + 7
(18-49)
426
(-)
-
Negative
Contact us
if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:
Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:
Number of polymorphisms tested per gene and per sample.
Onset Age and Age:
Mean or median age at onset or examination, respectively.
DX:
Criteria used to determine SZ diagnosis -> "IIIR"(DSM-IIIR), "IV" (DSM-IV), "9" (ICD-9), "10" (ICD-10), "M" (Mixed), "RDC" (Research Diagnostic Criteria), "U" (Unknown).
Result:
Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-)
: Either no data provided or in case of overlap, data included in original study.
SZGene Recent Updates
SZGene Stats
Studies: 1727
Genes: 1008
Polymorphisms: 8788
Meta-analyses: 287
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