SZGene

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SZGene - Gene overview of all published SZ-association studies for NR4A2

Gene:

NR4A2 (NOT; RNR1; HZF-3; NURR1; TINUR)

View on PDGene

Protein:

nuclear receptor subfamily 4, group A, member 2 (T-cell nuclear receptor NOT; orphan nuclear receptor NURR1; intermediate-early receptor protein; nur related protein-1 (mouse), human homolog of; NGFI-B/nur77 beta-type transcription factor homolog; ranscriptionally inducible nuclear receptor related 1)

Chromosome:

2 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 22 October 2010

1. Case-Control Studies (by ethnic group)
				SZ Cases				Normal Controls
Study	Population	Source	# Polys	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result	Comment
Caucasian
Buervenich, 2000	Sweden	CL	1 (detail)	135 (-)	IIIR	-	-	136 (-)	-	Negative
Buervenich, 2000	USA	CL	1 (detail)	160 (-)	IIIR	-	-	90 (-)	-	Negative
Carmine, 2003	Sweden	CL	3 (detail)	134 (37%)	IIIR	-	45 + 17 (20-90)	207 (37%)	40 + 10 (19-86)	Negative
Carmine, 2003	USA	CL	2 (detail)	141 (35%)	IV	-	45 + 17 (20-90)	139 (55%)	40 + 10 (19-86)	Negative
Novak, 2010a	Overlaps with Novak, 2010b	CO	2 (detail)	171 (35%)	IV	-	38 (-)	151 (-)	-	n.a.
Novak, 2010b	Canada	CO	2 (detail)	385 (30%)	IV	-	-	190 (36%)	-	Negative
Talkowski, 2008	USA	CL	5 (detail)	328 (-)	IV	-	-	501 (-)	-	Negative
Asian
Chen, 2001	Taiwan	CL	1 (detail)	177 (46%)	IV	-	47 (-)	130 (42%)	45 (-)	Negative
Ishiguro, 2002	Japan	CL	2 (detail)	296 (45%)	IV	23.5 (12-52)	45.3 (18-80)	186 (42%)	48.3 (32-65)	Negative
Iwayama-Shigeno, 2003	Japan	CL	3 (detail)	180 (49%)	IV	-	47.4 + 12.7 (-)	180 (50%)	43 + 11 (-)	Negative

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

2. Family-Based Studies (by ethnic group)
				Affecteds				Unaffecteds
Study	Population	# Polys	# Families	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result	Comment
Caucasian
Talkowski, 2008	USA	5 (detail)	150	150 (50%)	IV	-	-	300 (50%)	-	Negative

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine SZ diagnosis -> "IIIR"(DSM-IIIR), "IV" (DSM-IV), "9" (ICD-9), "10" (ICD-10), "M" (Mixed), "RDC" (Research Diagnostic Criteria), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.


SZGene Recent Updates
SZGene Stats Studies: 1727 Genes: 1008 Polymorphisms: 8788 Meta-analyses: 287





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