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SZGene - Gene overview of all published SZ-association studies for NOTCH4    
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 Gene: NOTCH4  (INT3)  Entrez Gene    View on AlzGene   View on MSGene
 Protein: notch4   ProteinLink
 Chromosome: 6   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 22 October 2010
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      SZ Cases Normal Controls    
Study Population Source # Polys # Subjects
(% women)		 DX Onset Age
(range)		 Age
(range)		 # Subjects
(% women)		 Age
(range)		 Result Comment
 Caucasian
Anttila, 2003
 Finland CL  1  (detail)  94
(51%)		IV29.6 + 10.1
(-)		46 + 11.1
(-)		94
(-)		-Negative
Anttila, 2004
 Overlaps with
Anttila, 2003		 CL  1  (detail)  94
(51%)		IV--98
(-)		-n.a.
Betcheva, 2009
 Bulgaria (I) CL  4  (detail)  185
(-)		IV--184
(-)		-Positive
Betcheva, 2009
 Bulgaria (II) CL  2  (detail)  70
(-)		IV--372
(-)		-Negative
Carmine, 2003
 Sweden CL  2  (detail)  74
(39%)		IIIR--135
(33%)		-Negative
Ikeda, 2010
 UK (published GWAS) CL  1  (detail)  479
(-)		U--2938
(-)		-Negative
ISC, 2009
 UK (London; GWAS) CL  1  (detail)  523
(29%)		M--505
(58%)		-Positive
ISC, 2009
 Ireland (GWAS) CL  1  (detail)  275
(31%)		M--866
(70%)		-Positive
ISC, 2009
 Portugal (GWAS) CL  1  (detail)  347
(38%)		M--216
(63%)		-Positive
ISC, 2009
 Sweden-I (GWAS) CL  1  (detail)  170
(-)		M--170
(-)		-Positive
ISC, 2009
 Sweden-II (GWAS) CL  1  (detail)  390
(-)		M--230
(-)		-Positive
ISC, 2009
 UK (Aberdeen; GWAS) CL  1  (detail)  720
(26%)		M--702
(36%)		-Positive
ISC, 2009
 UK (Edinburgh; GWAS) CL  1  (detail)  369
(27%)		M--287
(48%)		-Positive
ISC, 2009
 Bulgaria (GWAS) CL  1  (detail)  528
(49%)		M--611
(52%)		-Positive
Ivo, 2006
 Germany CL  10  (detail)  512
(-)		IIIR--232
(69%)		-Negative
Luo, 2004
 USA CL  2  (detail)  223
(-)		IIIR--211
(-)		-Negative
McGinnis, 2001
 UK (Scotland) CL  2  (detail)  324
(-)		U--692
(-)		-Negative
Sklar, 2001
 UK PO  3  (detail)  142
(-)		IV--161
(67%)		-Negative
Stefansson, 2009
 Italy (GWAS) CL  1  (detail)  84
(-)		10--89
(-)		-Negative
Stefansson, 2009
 Netherlands-I (Follow-up) CL  1  (detail)  715
(-)		IV--3634
(-)		-Negative
Stefansson, 2009
 Norway (Follow-up) CL  1  (detail)  114
(-)		M--170
(-)		-Negative
Stefansson, 2009
 UK (England; GWAS) CL  1  (detail)  93
(-)		10--88
(-)		-Negative
Stefansson, 2009
 Russia (Follow-up) CL  1  (detail)  484
(-)		IV--491
(-)		-Trend
Stefansson, 2009
 Spain (Santiago; Follow-up) CL  1  (detail)  296
(-)		IV--625
(-)		-Negative
Stefansson, 2009
 Spain (Valencia; Follow-up) CL  1  (detail)  371
(-)		IV--417
(-)		-Negative
Stefansson, 2009
 Sweden (Follow-up) CL  1  (detail)  255
(-)		M--293
(-)		-Trend
Stefansson, 2009
 Denmark (Aarhus; Follow-up) CL  1  (detail)  680
(-)		M--1110
(-)		-Negative
Stefansson, 2009
 Denmark (Copenhagen; Follow-up) CL  1  (detail)  513
(-)		10--1339
(-)		-Positive
Stefansson, 2009
 Finland (Follow-up) CL  1  (detail)  287
(-)		IV--3987
(-)		-Trend
Stefansson, 2009
 Finland (Helsinki; GWAS) CL  1  (detail)  59
(-)		IV--147
(-)		-Positive
Stefansson, 2009
 Finland (Kuusamo; GWAS) CL  1  (detail)  123
(-)		IV--50
(-)		-Negative
Stefansson, 2009
 Germany (Bonn; Follow-up) CL  1  (detail)  618
(-)		IV--1550
(-)		-Negative
Stefansson, 2009
 Germany (Bonn; GWAS) CL  1  (detail)  483
(-)		IV--367
(-)		-Trend
Stefansson, 2009
 Germany (Munich; Follow-up) CL  1  (detail)  303
(-)		IV--1625
(-)		-Positive
Stefansson, 2009
 Germany (Munich; GWAS) CL  1  (detail)  574
(-)		IV--604
(-)		-Negative
Stefansson, 2009
 Hungary (Follow-up) CL  1  (detail)  272
(-)		IV--227
(-)		-Negative
Stefansson, 2009
 Iceland (GWAS) CL  1  (detail)  589
(-)		M--11492
(-)		-Negative
Stefansson, 2009
 UK (Scotland; GWAS) CL  1  (detail)  658
(-)		M--661
(-)		-Positive
Stefansson, 2009
 Netherlands-II (Follow-up) CL  1  (detail)  91
(-)		IV--87
(-)		-Negative
 African Descent
Luo, 2004
 USA, Canada CL  2  (detail)  123
(-)		IIIR--85
(-)		-Positive
 Asian
Fan, 2002
 China CL  5  (detail)  544
(47%)		IIIR-42 + 16.5
(-)		621
(50%)		41.5 + 16.1
(-)		Negative
Ikeda, 2010
 Japan (GWAS) CL  2  (detail)  575
(-)		IV-43.5 + 14.8
(-)		564
(-)		44 + 14.4
(-)		Positive
Ikeda, 2010
 Japan (REP) CL  2  (detail)  1511
(-)		IV-45.9 + 14
(-)		1517
(-)		46 + 14.6
(-)		Positive
Imai, 2001
 Japan CL  1  (detail)  102
(40%)		IV25.9 + 8.7
(-)		46.7 + 13.4
(-)		100
(70%)		39.8 + 11.8
(-)		Negative
Kaneko, 2004
 Japan CL  5  (detail)  235
(48%)		IV30 + 9.4
(-)		46 + 13.3
(-)		235
(48%)		42.8 + 10.8
(-)		Negative
Li, 2010
 China CL  1  (detail)  2496
(45%)		IV25.6 + 8.1
(-)		-5184
(48%)		56.2 + 12.8
(-)		Positive
Shibata, 2006
 Japan CL  3  (detail)  191
(47%)		IV-40.6 + 13.7
(17-47)		133
(53%)		51.5 + 18.4
(28-58)		Negative
Tochigi, 2004
 Japan CL  6  (detail)  284
(43%)		IV-46.1 + 14.6
(-)		284
(43%)		40.1 + 11.5
(-)		Negative
Tochigi, 2007
 Japan CL  4  (detail)  241
(43%)		IV-46.2 + 14.8
(-)		290
(43%)		41.6 + 11.6
(-)		Trend
Tochigi, 2007
 Overlaps with
Tochigi, 2004		 CL  3  (detail)  241
(43%)		IV-46.2 + 14.8
(-)		290
(43%)		41.6 + 11.6
(-)		n.a.
Ujike, 2001
 Japan CL  3  (detail)  188
(42%)		10-44.7 + 14
(-)		143
(56%)		42.6 + 15.1
(-)		Negative
 Other/Mixed
Wassink, 2003
 USA CL  1  (detail)  210
(26%)		M-28.5 + 9.2
(-)		85
(49%)		28.4 + 7.8
(-)		Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds    
Study Population # Polys # Families # Subjects
(% women)		 DX Onset Age
(range)		 Age
(range)		 # Subjects
(% women)		 Age
(range)		 Result Comment
 Caucasian
Ivo, 2006
 Germany  10  (detail)  159159
(-)		IIIR--318
(50%)		-Negative
Prasad, 2004
 USA  5  (detail)  148148
(-)		IV--296
(50%)		-Positive
Sklar, 2001
 Bulgaria  3  (detail)  108108
(-)		IV--216
(50%)		-Negative
Sklar, 2001
 Germany (I)  3  (detail)  251251
(-)		IV--502
(50%)		-Negative
Skol, 2003
 USA (II)  5  (detail)  62-IIIR----Negative
Wei, 2000
 UK  5  (detail)  8080
(-)		U--160
(50%)		-Positive
 African Descent
Skol, 2003
 USA (I)  5  (detail)  60-IIIR----Positive
 Asian
Fan, 2002
 China  5  (detail)  327327
(45%)		IIIR-25.8 + 7.7
(-)		654
(50%)		-Negative
Kaneko, 2004
 Japan  5  (detail)  7878
(44%)		IV30 + 9.4
(-)		-156
(50%)		-Negative
Liu, 2006
 Taiwan  7  (detail)  218461
(38%)		IV22.2 + 6.2
(-)		34.5 + 9.4
(-)		403
(53%)		52.6 + 15.3
(-)		Positive
Proitsi, 2008
 China  2  (detail)  307307
(50%)		IV--614
(50%)		-Negative
Takahashi, 2003
 Japan, China  6  (detail)  123123
(50%)		IV22.9 + 5.4
(-)		29.5 + 5.7
(-)		246
(50%)		60.5 + 7.3
(-)		Negative
Wang, 2006
 China  4  (detail)  282282
(36%)		10-25.5 + 6.7
(-)		564
(50%)		-Positive
Zhang, 2004
 Overlaps with
Wang, 2006		  4  (detail)  141141
(-)		10--182
(77%)		-Positive
 Other/Mixed
Ivo, 2006
 Palestine  10  (detail)  208208
(-)		IV--416
(50%)		-Negative
Miranda, 2006
 Colombia  1  (detail)  110-IV----Negative
Prasad, 2004
 India  5  (detail)  182182
(-)		IV--364
(50%)		-Positive
Sklar, 2001
 Germany (II)  3  (detail)  160160
(-)		IV--160
(-)		-Negative
Skol, 2003
 USA (III)  5  (detail)  44-IIIR----Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine SZ diagnosis ->  "IIIR"(DSM-IIIR), "IV" (DSM-IV), "9" (ICD-9), "10" (ICD-10), "M" (Mixed), "RDC" (Research Diagnostic Criteria), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
SZGene Recent Updates
SZGene Stats
Studies: 1727
Genes: 1008
Polymorphisms: 8788
Meta-analyses: 287
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