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SZGene - Gene overview of all published SZ-association studies for MTHFR    
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 Gene: MTHFR   Entrez Gene    View on ALSGene   View on AlzGene   View on MSGene   View on PDGene
 Protein: 5,10-methylenetetrahydrofolate reductase (NADPH)  (methylenetetrahydrofolate reductase)  ProteinLink
 Chromosome: 1   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 22 October 2010
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      SZ Cases Normal Controls    
Study Population Source # Polys # Subjects
(% women)		 DX Onset Age
(range)		 Age
(range)		 # Subjects
(% women)		 Age
(range)		 Result Comment
 Caucasian
Betcheva, 2009
 Bulgaria CL  2  (detail)  185
(-)		IV--184
(-)		-Negative
Jonsson, 2007
 Denmark CL  2  (detail)  388
(42%)		10-44.4 + 12.2
(-)		1006
(42%)		44.2 + 11.8
(-)		Negative
Jonsson, 2007
 Norway CL  2  (detail)  132
(39%)		IV-36.6 + 9.8
(-)		177
(55%)		39.7 + 10.3
(-)		Negative
Jonsson, 2007
 Sweden CL  2  (detail)  233
(37%)		IIIR-55.7 + 15.6
(-)		293
(38%)		51.2 + 10.1
(-)		Negative
Joober, 2000
 Canada CL  1  (detail)  105
(29%)		IV-39.4 + 8.3
(-)		90
(-)		-Positive
Kempisty, 2006
 Poland CL  1  (detail)  200
(50%)		M-31.1 + 11.5
(21-67)		300
(47%)		42.6 + 9.9
(21-80)		Positive
Kempisty, 2007
 Poland CL  1  (detail)  200
(50%)		M36
(-)		44.7 + 13.7
(28-80)		300
(47%)		40.4 + 9.9
(18-82)		Positive
Muntjewerff, 2003
 Overlaps with
Muntjewerff, 2005		 CL  1  (detail)  35
(23%)		IV-39.4 + 9
(-)		104
(71%)		35.5 + 8.4
(-)		n.a.
Muntjewerff, 2005
 Netherlands CL  1  (detail)  254
(28%)		IV-41 + 14
(-)		432
(57%)		51 + 14
(-)		Positive
Muntjewerff, 2007
 Overlaps with
Muntjewerff, 2005		 CL  1  (detail)  252
(27%)		IV-41 + 14
(-)		405
(59%)		51 + 13
(-)		n.a.
Philibert, 2006
 USA CL  1  (detail)  206
(36%)		IV--359
(49%)		-Negative
Sazci, 2003
 Turkey CL  2  (detail)  130
(10%)		IV-42.2 + 13.1
(-)		266
(8%)		43.5 + 15.8
(-)		Positive
Sazci, 2005
 Turkey CL  2  (detail)  297
(43%)		IV-41.2 + 9.4
(-)		341
(44%)		40.9 + 8.1
(-)		Positive
Vilella, 2005
 Spain CL  2  (detail)  158
(41%)		9-55.4 + 12.1
(23-76)		234
(45%)		46.4 + 14.5
(19-75)		Negative
Virgos, 1999
 Overlaps with
Virgos, 1999		 CL  1  (detail)  210
(33%)		9-58
(19-76)		218
(11%)		58
(19-85)		n.a.
Yu, 2004
 UK (Scotland) CL  2  (detail)  426
(-)		IIIR--628
(-)		-Negative
 Asian
Arinami, 1997
 Japan CL  1  (detail)  297
(43%)		IIIR-45.2 + 13
(-)		419
(33%)		48.5 + 8.7
(-)		Positive
Feng, 2009
 China CL  1  (detail)  123
(59%)		IV-31.7
(-)		123
(57%)		33.8
(-)		Positive
Hokyo, 2010
 Japan CL  1  (detail)  407
(42%)		IV-54.7
(-)		384
(64%)		40.1
(-)		Negative
Kunugi, 1998
 Japan CL  1  (detail)  343
(51%)		IV-42.2 + 12.8
(-)		258
(50%)		31.3 + 11.3
(-)		Negative
Lee, 2006
 Korea CL  2  (detail)  235
(57%)		IV--235
(57%)		-Positive
Tan, 2004
 Singapore CL  1  (detail)  236
(24%)		IV-55.2 + 10.3
(30-88)		120
(60%)		44.7 + 16.3
(21-92)		Trend
Yu, 2004
 China CL  2  (detail)  230
(-)		IIIR--251
(-)		-Negative
Zhang, 2010
 China CL  1  (detail)  379
(42%)		IV-32.1 + 9.7
(-)		380
(43%)		31.5 + 8.6
(-)		Positive
 Hispanic
Garcia-Miss, 2009
 Mexico CL  1  (detail)  105
(30%)		IV--108
(49%)		-Negative
 Other/Mixed
Roffman, 2008
 USA CL  1  (detail)  79
(-)		IV--75
(-)		-Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds    
Study Population # Polys # Families # Subjects
(% women)		 DX Onset Age
(range)		 Age
(range)		 # Subjects
(% women)		 Age
(range)		 Result Comment
 Caucasian
Muntjewerff, 2007
 Netherlands  1  (detail)  120-IV----Negative
Wei, 1999
 UK  1  (detail)  56-U----Positive
 Asian
Zhang, 2009
 China  2  (detail)  111111
(50%)		U--143
(100%)		47.3 + 4.6
(-)		Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine SZ diagnosis ->  "IIIR"(DSM-IIIR), "IV" (DSM-IV), "9" (ICD-9), "10" (ICD-10), "M" (Mixed), "RDC" (Research Diagnostic Criteria), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
SZGene Recent Updates
SZGene Stats
Studies: 1727
Genes: 1008
Polymorphisms: 8788
Meta-analyses: 287
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