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SZGene - Gene overview of all published SZ-association studies for DRD4    
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 Gene: DRD4  (D4DR)  Entrez Gene    View on AlzGene   View on PDGene
 Protein: dopamine receptor D4  (D(2C) dopamine receptor; seven transmembrane helix receptor)  ProteinLink
 Chromosome: 11   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 21 October 2010
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      SZ Cases Normal Controls    
Study Population Source # Polys # Subjects
(% women)		 DX Onset Age
(range)		 Age
(range)		 # Subjects
(% women)		 Age
(range)		 Result Comment
 Caucasian
Alfimova, 2007
 Russia CL  2  (detail)  150
(54%)		10-34.3 + 12.7
(-)		118
(43%)		35.5 + 13
(-)		Negative
Campion, 1994
 France CL  1  (detail)  80
(-)		III--80
(-)		-Negative
Catalano, 1993
 Italy CL  1  (detail)  79
(43%)		IIIR21.9 + 4.7
(13-34)		34.1 + 11.1
(16-73)		75
(57%)		30 + 7.1
(20-52)		Negative
Cichon, 1995
 Germany CL  2  (detail)  256
(-)		IIIR24.6 + 7.3
(-)		31.8 + 9.8
(-)		148
(-)		30.6 + 9.1
(-)		Negative
Daniels, 1994
 UK CL  1  (detail)  106
(44%)		IIIR-46.3 + 15.8
(-)		119
(40%)		49.6 + 18.8
(-)		Negative
Dollfus, 1996
 France CL  1  (detail)  62
(-)		IIIR--161
(-)		-Negative
Hoogendoorn, 2005
 Netherlands CL  1  (detail)  282
(-)		IV--585
(-)		-Negative
Jonsson, 1996
 Sweden CL  1  (detail)  118
(36%)		IIIR-45.8
(20-90)		78
(42%)		38.7 + 29
(56-56)		Negative
Jonsson, 2001
 Sweden CL  1  (detail)  132
(36%)		IIIR-44.8 + 17.1
(-)		388
(44%)		42.6 + 13.3
(-)		Negative
Kaiser, 2000
 Germany CL  1  (detail)  638
(45%)		IV27 + 9.5
(12-66)		37 + 12.2
(18-70)		752
(25%)		-Negative
Kohn, 1997
 Israel CL  2  (detail)  98
(-)		IIIR--204
(-)		-Negative
Kotler, 1999
 Israel CL  1  (detail)  92
(35%)		10--415
(0%)		28 + 15
(-)		Negative
Nothen, 1993
 Germany CL  1  (detail)  60
(33%)		IIIR25.2 + 8
(14-46)		34.8 + 11
(-)		60
(47%)		28.2 + 5.2
(-)		Negative
Nothen, 1994
 Germany CL  1  (detail)  118
(-)		IIIR--232
(-)		-Negative
Olsen, 2005
 Denmark CL  1  (detail)  242
(38%)		10-42.9 + 12.3
(-)		178
(39%)		46.9 + 9.1
(-)		Negative
Pal, 2009
 Croatia CL  4  (detail)  103
(42%)		10-43.6 + 10.6
(23-74)		131
(-)		50.3 + 7.5
(30-74)		Positive
Paterson, 1996
 USA, Canada CL  1  (detail)  45
(-)		IIIR--41
(-)		-Negative
Sanak, 2005
 Poland CL  1  (detail)  237
(50%)		M-37.7 + 12.7
(-)		241
(59%)		36.8 + 9.3
(-)		Trend
Serretti, 1999
 Italy CL  2  (detail)  229
(31%)		IIIR22.3 + 11.2
(-)		35.2 + 13.9
(-)		471
(55%)		42.5 + 13.9
(-)		Negative
Serretti, 2001
 Italy CL  1  (detail)  419
(-)		IV--601
(56%)		47.4 + 14.9
(-)		Negative
Sommer, 1993
 USA CL  1  (detail)  115
(30%)		IIIR26.6 + 7.4
(-)		38.3 + 12
(-)		115
(62%)		65 + 12.2
(-)		Negative
Talkowski, 2008
 USA CL  3  (detail)  328
(-)		IV--501
(-)		-Negative
Weiss, 1996
 Germany CL  1  (detail)  91
(57%)		10-36.6
(-)		92
(43%)		41.5
(-)		Positive
 African Descent
Seeman, 1994
 USA, Canada, Caribbean CL  1  (detail)  183
(-)		IIIR--24
(-)		-Negative
 Asian
Fujiwara, 1997
 Japan CL  1  (detail)  17
(-)		M--11
(-)		-Positive
Hattori, 2008
 Japan CL  1  (detail)  570
(50%)		IV-47 + 11.4
(-)		570
(50%)		46.7 + 11.1
(-)		Negative
Hokyo, 2010
 Japan CL  1  (detail)  407
(42%)		IV-54.7
(-)		384
(64%)		40.1
(-)		Negative
Hong, 1997
 Taiwan CL  1  (detail)  42
(50%)		IIIR-30.8 + 8
(-)		42
(38%)		28.7 + 4.4
(-)		Negative
Hong, 1998
 Taiwan CL  1  (detail)  80
(50%)		IIIR-29.2 + 6.6
(-)		42
(38%)		28.7 + 4.4
(-)		Negative
Iwata, 2003
 Japan CL  1  (detail)  51
(57%)		IV13.5 + 1.7
(9-16)		20 + 7
(-)		148
(56%)		21 + 7
(-)		Negative
Lai, 2010
 China CL  3  (detail)  322
(48%)		IIIR-40.6 + 16.8
(-)		300
(50%)		43.2 + 17.6
(-)		Positive
Lung, 2002
 Taiwan CL  1  (detail)  305
(-)		IIIR--80
(-)		-Negative
Lung, 2006
 Taiwan CO  2  (detail)  630
(-)		IIIR-35.3 + 10.8
(-)		428
(-)		45.3 + 13.9
(-)		Positive
Lung, 2009
 Taiwan CL  1  (detail)  934
(31%)		IV-36.6 + 12.2
(-)		433
(56%)		45.3 + 13.9
(-)		Positive
Mitsuyasu, 2001
 Overlaps with
Mitsuyasu, 2006		 CL  5  (detail)  208
(44%)		IV-51.5 + 13.9
(-)		210
(43%)		50.5 + 5
(-)		n.a.
Mitsuyasu, 2006
 Japan CL  17  (detail)  216
(44%)		IV-51.5 + 13.7
(18-82)		243
(43%)		50.2 + 4.6
(30-71)		Negative
Nakajima, 2006
 Japan CL  9  (detail)  570
(50%)		IV-47 + 11.4
(-)		570
(50%)		46.7 + 11.1
(-)		Positive
Nakamura, 1995
 Japan CL  1  (detail)  110
(-)		U-47.3
(-)		52
(-)		32.8
(-)		Positive
Nanko, 1993
 Japan CL  1  (detail)  80
(-)		U--81
(-)		-Negative
Ohara, 1996
 Japan CL  2  (detail)  153
(50%)		IV26.3 + 9.5
(-)		46.3 + 16
(-)		121
(58%)		34.4 + 14.1
(-)		Negative
Okuyama, 1999
 Japan CL  1  (detail)  252
(40%)		IIIR24.3
(15-47)		47.1
(20-80)		269
(39%)		47.9
(35-75)		Positive
Tanaka, 1995
 Japan CL  1  (detail)  70
(46%)		IIIR-44.7 + 11.8
(15-70)		70
(36%)		45.8 + 25
(22-86)		Negative
Tani, 1997
 Japan CL  1  (detail)  49
(31%)		IIIR28.4 + 6.9
(17-40)		54.9 + 10.9
(25-72)		50
(30%)		54.6 + 11.5
(29-79)		Negative
Xing, 2003
 China CL  7  (detail)  210
(-)		IIIR-41.2 + 16.9
(-)		206
(50%)		41.8 + 16.2
(-)		Positive
 Hispanic
Aguirre, 2007
 Mexico CL  2  (detail)  94
(-)		IIIR--169
(49%)		40 + 14
(19-70)		Positive
Fresan, 2007
 Mexico CL  1  (detail)  71
(31%)		IV21.4 + 6.2
(11-42)		30.5 + 7.9
(18-47)		202
(49%)		36.4 + 11.4
(-)		n.a.
 Other/Mixed
Petronis, 1995
 USA, Canada CL  4  (detail)  50
(-)		IIIR--50
(-)		-Trend
Rao, 1994
 USA CL  1  (detail)  41
(-)		IIIR--27
(-)		-Negative
Srivastava, 2010
 India CL  3  (detail)  215
(48%)		IV21.4 + 6.1
(-)		29.3 + 8.9
(-)		215
(40%)		34.6 + 12.4
(-)		Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds    
Study Population # Polys # Families # Subjects
(% women)		 DX Onset Age
(range)		 Age
(range)		 # Subjects
(% women)		 Age
(range)		 Result Comment
 Caucasian
Ambrosio, 2004
 Portugal  3  (detail)  9090
(36%)		IV--180
(50%)		-Negative
Campion, 1994
 France  1  (detail)  37-IIIR--80
(-)		-Negative
Fallin, 2005
 USA  1  (detail)  263274
(26%)		IV19.5 + 4.5
(-)		-548
(50%)		-Negative
Macciardi, 1994
 Italy  1  (detail)  4242
(26%)		IIIR-26
(19-45)		84
(50%)		-Negative
Talkowski, 2008
 USA  3  (detail)  150150
(50%)		IV--300
(50%)		-Negative
 Asian
Hattori, 2008
 Japan  1  (detail)  124163
(-)		IV--213
(-)		-Negative
Hong, 1997
 Taiwan  1  (detail)  4747
(32%)		IIIR-34 + 8.1
(-)		35
(43%)		34.1 + 9
(-)		Negative
 Other/Mixed
Fanous, 2004
 USA  1  (detail)   540
(-)		IIIR--709
(-)		-Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine SZ diagnosis ->  "IIIR"(DSM-IIIR), "IV" (DSM-IV), "9" (ICD-9), "10" (ICD-10), "M" (Mixed), "RDC" (Research Diagnostic Criteria), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
SZGene Recent Updates
SZGene Stats
Studies: 1727
Genes: 1008
Polymorphisms: 8788
Meta-analyses: 287
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