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SZGene - Gene overview of all published SZ-association studies for APOE    
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 Gene: APOE  (AD2; apoprotein)  Entrez Gene    View on ALSGene   View on AlzGene   View on MSGene   View on PDGene
 Protein: apolipoprotein E  (apolipoprotein E3; Alzheimer disease 2 (APOE*E4-associated, late onset))  ProteinLink
 Chromosome: 19   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 1 December 2010
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      SZ Cases Normal Controls    
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Arnold, 1997
USA (I) CL  1  (detail)  56
(-)
IIIR--75
(-)
-Negative
Dean, 2003
Australia CL  2  (detail)  23
(35%)
IV-42 + 2.7
(-)
47
(36%)
55 + 2.7
(-)
Negative
Durany, 2000
Spain CL  1  (detail)  114
(57%)
10-56 + 15
(26-90)
94
(49%)
60 + 15
(16-95)
Negative
Harrington, 1995
UK CL  1  (detail)  42
(57%)
U-65.8 + 17.3
(19-95)
131
(46%)
76.1 + 14.4
(19-98)
Positive
Howard, 1995
UK CL  1  (detail)  23
(-)
U--325
(-)
-Negative
Jonsson, 1996
Sweden CL  1  (detail)  87
(36%)
IIIR-46.8
(20-90)
57
(40%)
38.6
(29-55)
Negative
Joober, 1996
Canada CL  1  (detail)  51
(-)
U-41.5 + 9.1
(-)
35
(-)
65.4 + 12
(-)
Negative
Jungerius, 2007
Netherlands CL  2  (detail)  310
(-)
IV--880
(-)
-Negative
Kampman, 2004
Finland CL  1  (detail)  94
(51%)
IV29.7 + 9.9
(-)
45.9 + 10.9
(-)
98
(-)
-Negative
Martinoli, 1995
Canada CL  1  (detail)  9
(-)
IIIR-80
(72-99)
243
(-)
-Negative
Martorell, 2001
Spain CL  1  (detail)  365
(39%)
9-56.9 + 16.3
(19-90)
584
(37%)
52.2 + 18.5
(19-97)
Negative
Martorell, 2007
Spain CL  4  (detail)  585
(34%)
IV-48.8 + 17.5
(-)
615
(48%)
43.1 + 15.3
(-)
Negative
Saiz, 2002
Spain CL  1  (detail)  106
(43%)
IV-35.1 + 10.3
(-)
250
(52%)
46 + 15
(-)
Negative
Schurhoff, 2003
France CL  1  (detail)  114
(51%)
IV--91
(41%)
50.9 + 5.3
(-)
Trend
Sorbi, 1998
Italy CL  1  (detail)  69
(32%)
IIIR47.5 + 14.5
(-)
-121
(72%)
60.3 + 18.1
(27-81)
Negative
St Clair, 1997
UK (Scotland) CL  1  (detail)  175
(-)
IV--400
(-)
-Negative
Thibaut, 1998
France CL  1  (detail)  134
(33%)
IIIR22.9 + 6.5
(-)
42.3 + 12.5
(-)
103
(42%)
44.1 + 11.5
(-)
Negative
Thibaut, 1999
Overlaps with
Thibaut, 1998
CL  1  (detail)  106
(27%)
IIIR-38.6 + 9.1
(22-60)
98
(41%)
41.6 + 11.7
(21-60)
n.a.
Town, 1997
USA CO  1  (detail)  63
(-)
IIIR-42.9 + 8.6
(-)
301
(-)
71.7 + 7.6
(-)
Negative
Vila-Rodriguez, 2010
Canada CL  1  (detail)  35
(26%)
IV21.3 + 6.1
(-)
42.6 + 8.5
(-)
35
(26%)
44.2 + 7.6
(-)
Negative
Zhu, 1996
Germany CL  1  (detail)  98
(38%)
IIIR24.9 + 8.4
(9-48)
32.9 + 10.4
(19-61)
98
(-)
-Negative
 African Descent
Arnold, 1997
USA (II) CL  1  (detail)  37
(-)
IIIR--31
(-)
-Negative
 Asian
Chen, 1999
Taiwan CL  1  (detail)  237
(-)
IV--137
(-)
-Positive
Igata-Yi, 1997
Japan CL  1  (detail)  54
(72%)
IV36 + 22.5
(12-87)
-33
(48%)
53.2 + 15.7
(24-88)
Positive
Kimura, 1997a
Overlaps with
Kimura, 2000a
CL  1  (detail)  164
(51%)
IIIR-45.2 + 17.6
(-)
141
(64%)
42.3 + 10.6
(-)
n.a.
Kimura, 1997b
Overlaps with
Kimura, 2000a
CL  1  (detail)  122
(51%)
IIIR-47 + 17.6
(-)
126
(64%)
42 + 10.2
(-)
n.a.
Kimura, 2000a
Japan CL  1  (detail)  333
(50%)
IV-40.9 + 17.7
(-)
191
(70%)
40.5 + 13.2
(-)
Negative
Kimura, 2000b
Overlaps with
Kimura, 2000a
CL  1  (detail)  314
(49%)
IV-41.2 + 17.7
(-)
188
(71%)
40.6 + 13.2
(-)
n.a.
Lan, 1997
Overlaps with
Chen, 1999
CL  1  (detail)  62
(65%)
IV-35.7 + 8.6
(19-55)
63
(43%)
35.4 + 4.9
(24-48)
n.a.
Lee, 2001
Korea CL  1  (detail)  60
(35%)
IV-32.9 + 7
(-)
60
(50%)
35 + 8.9
(-)
Positive
Liu, 2003
China CL  1  (detail)  579
(55%)
IV--1528
(30%)
33 + 83
(-)
Positive
Shinkai, 1998
Japan CL  2  (detail)  144
(57%)
IV-54.3 + 11.2
(-)
134
(52%)
55.4 + 6.8
(-)
Negative
 Other/Mixed
Akanji, 2009
Kuwait CL  1  (detail)  207
(-)
IV-36
(15-76)
165
(-)
38
(22-61)
Positive
Fernandez, 1999
USA CL  1  (detail)  40
(-)
IIIR10.2 + 1.8
(-)
15 + 2.5
(-)
57
(-)
15.7 + 9.1
(-)
Negative
Moberg, 2006
USA CL  1  (detail)  28
(50%)
IV-36.6 + 9.1
(-)
26
(42%)
29.4 + 11.2
(-)
Negative
Powchik, 1997
USA CL  1  (detail)  116
(46%)
IIIR-77.1 + 11.4
(-)
19
(53%)
79.4 + 11.9
(-)
Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine SZ diagnosis ->  "IIIR"(DSM-IIIR), "IV" (DSM-IV), "9" (ICD-9), "10" (ICD-10), "M" (Mixed), "RDC" (Research Diagnostic Criteria), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
SZGene Recent Updates
SZGene Stats
Studies: 1727
Genes: 1008
Polymorphisms: 8788
Meta-analyses: 287
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