SZGene

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SZGene - Gene overview of all published SZ-association studies for APOE

Gene:

APOE (AD2; apoprotein)

View on ALSGene View on AlzGene View on MSGene View on PDGene

Protein:

apolipoprotein E (apolipoprotein E3; Alzheimer disease 2 (APOE*E4-associated, late onset))

Chromosome:

19 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 1 December 2010

1. Case-Control Studies (by ethnic group)
				SZ Cases				Normal Controls
Study	Population	Source	# Polys	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result	Comment
Caucasian
Arnold, 1997	USA (I)	CL	1 (detail)	56 (-)	IIIR	-	-	75 (-)	-	Negative
Dean, 2003	Australia	CL	2 (detail)	23 (35%)	IV	-	42 + 2.7 (-)	47 (36%)	55 + 2.7 (-)	Negative
Durany, 2000	Spain	CL	1 (detail)	114 (57%)	10	-	56 + 15 (26-90)	94 (49%)	60 + 15 (16-95)	Negative
Harrington, 1995	UK	CL	1 (detail)	42 (57%)	U	-	65.8 + 17.3 (19-95)	131 (46%)	76.1 + 14.4 (19-98)	Positive
Howard, 1995	UK	CL	1 (detail)	23 (-)	U	-	-	325 (-)	-	Negative
Jonsson, 1996	Sweden	CL	1 (detail)	87 (36%)	IIIR	-	46.8 (20-90)	57 (40%)	38.6 (29-55)	Negative
Joober, 1996	Canada	CL	1 (detail)	51 (-)	U	-	41.5 + 9.1 (-)	35 (-)	65.4 + 12 (-)	Negative
Jungerius, 2007	Netherlands	CL	2 (detail)	310 (-)	IV	-	-	880 (-)	-	Negative
Kampman, 2004	Finland	CL	1 (detail)	94 (51%)	IV	29.7 + 9.9 (-)	45.9 + 10.9 (-)	98 (-)	-	Negative
Martinoli, 1995	Canada	CL	1 (detail)	9 (-)	IIIR	-	80 (72-99)	243 (-)	-	Negative
Martorell, 2001	Spain	CL	1 (detail)	365 (39%)	9	-	56.9 + 16.3 (19-90)	584 (37%)	52.2 + 18.5 (19-97)	Negative
Martorell, 2007	Spain	CL	4 (detail)	585 (34%)	IV	-	48.8 + 17.5 (-)	615 (48%)	43.1 + 15.3 (-)	Negative
Saiz, 2002	Spain	CL	1 (detail)	106 (43%)	IV	-	35.1 + 10.3 (-)	250 (52%)	46 + 15 (-)	Negative
Schurhoff, 2003	France	CL	1 (detail)	114 (51%)	IV	-	-	91 (41%)	50.9 + 5.3 (-)	Trend
Sorbi, 1998	Italy	CL	1 (detail)	69 (32%)	IIIR	47.5 + 14.5 (-)	-	121 (72%)	60.3 + 18.1 (27-81)	Negative
St Clair, 1997	UK (Scotland)	CL	1 (detail)	175 (-)	IV	-	-	400 (-)	-	Negative
Thibaut, 1998	France	CL	1 (detail)	134 (33%)	IIIR	22.9 + 6.5 (-)	42.3 + 12.5 (-)	103 (42%)	44.1 + 11.5 (-)	Negative
Thibaut, 1999	Overlaps with Thibaut, 1998	CL	1 (detail)	106 (27%)	IIIR	-	38.6 + 9.1 (22-60)	98 (41%)	41.6 + 11.7 (21-60)	n.a.
Town, 1997	USA	CO	1 (detail)	63 (-)	IIIR	-	42.9 + 8.6 (-)	301 (-)	71.7 + 7.6 (-)	Negative
Vila-Rodriguez, 2010	Canada	CL	1 (detail)	35 (26%)	IV	21.3 + 6.1 (-)	42.6 + 8.5 (-)	35 (26%)	44.2 + 7.6 (-)	Negative
Zhu, 1996	Germany	CL	1 (detail)	98 (38%)	IIIR	24.9 + 8.4 (9-48)	32.9 + 10.4 (19-61)	98 (-)	-	Negative
African Descent
Arnold, 1997	USA (II)	CL	1 (detail)	37 (-)	IIIR	-	-	31 (-)	-	Negative
Asian
Chen, 1999	Taiwan	CL	1 (detail)	237 (-)	IV	-	-	137 (-)	-	Positive
Igata-Yi, 1997	Japan	CL	1 (detail)	54 (72%)	IV	36 + 22.5 (12-87)	-	33 (48%)	53.2 + 15.7 (24-88)	Positive
Kimura, 1997a	Overlaps with Kimura, 2000a	CL	1 (detail)	164 (51%)	IIIR	-	45.2 + 17.6 (-)	141 (64%)	42.3 + 10.6 (-)	n.a.
Kimura, 1997b	Overlaps with Kimura, 2000a	CL	1 (detail)	122 (51%)	IIIR	-	47 + 17.6 (-)	126 (64%)	42 + 10.2 (-)	n.a.
Kimura, 2000a	Japan	CL	1 (detail)	333 (50%)	IV	-	40.9 + 17.7 (-)	191 (70%)	40.5 + 13.2 (-)	Negative
Kimura, 2000b	Overlaps with Kimura, 2000a	CL	1 (detail)	314 (49%)	IV	-	41.2 + 17.7 (-)	188 (71%)	40.6 + 13.2 (-)	n.a.
Lan, 1997	Overlaps with Chen, 1999	CL	1 (detail)	62 (65%)	IV	-	35.7 + 8.6 (19-55)	63 (43%)	35.4 + 4.9 (24-48)	n.a.
Lee, 2001	Korea	CL	1 (detail)	60 (35%)	IV	-	32.9 + 7 (-)	60 (50%)	35 + 8.9 (-)	Positive
Liu, 2003	China	CL	1 (detail)	579 (55%)	IV	-	-	1528 (30%)	33 + 83 (-)	Positive
Shinkai, 1998	Japan	CL	2 (detail)	144 (57%)	IV	-	54.3 + 11.2 (-)	134 (52%)	55.4 + 6.8 (-)	Negative
Other/Mixed
Akanji, 2009	Kuwait	CL	1 (detail)	207 (-)	IV	-	36 (15-76)	165 (-)	38 (22-61)	Positive
Fernandez, 1999	USA	CL	1 (detail)	40 (-)	IIIR	10.2 + 1.8 (-)	15 + 2.5 (-)	57 (-)	15.7 + 9.1 (-)	Negative
Moberg, 2006	USA	CL	1 (detail)	28 (50%)	IV	-	36.6 + 9.1 (-)	26 (42%)	29.4 + 11.2 (-)	Negative
Powchik, 1997	USA	CL	1 (detail)	116 (46%)	IIIR	-	77.1 + 11.4 (-)	19 (53%)	79.4 + 11.9 (-)	Negative

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine SZ diagnosis -> "IIIR"(DSM-IIIR), "IV" (DSM-IV), "9" (ICD-9), "10" (ICD-10), "M" (Mixed), "RDC" (Research Diagnostic Criteria), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.


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SZGene Stats Studies: 1727 Genes: 1008 Polymorphisms: 8788 Meta-analyses: 287





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