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Printable version
SZGene - Gene overview of all published SZ-association studies for KCNN3
Gene:
KCNN3
(SK3; hSK3; SKCA3; KCa2.3)
View on PDGene
Protein:
small conductance calcium-activated potassium channel protein 3
Chromosome:
1
(View:
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
X
Y
MT
)
Status:
Updated 18 October 2010
1. Case-Control Studies (by ethnic group)
SZ Cases
Normal Controls
Study
Population
Source
# Polys
# Subjects
(% women)
DX
Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
Comment
Caucasian
Bonnet-Brilhault, 1999
France
CL
1
(detail)
151
(26%)
IIIR
22.6 + 5.7
(-)
41 + 12.4
(-)
153
(24%)
38.8 + 12.3
(-)
Negative
Bowen, 1998
UK, Ireland
CL
1
(detail)
194
(-)
IIIR
-
-
183
(-)
-
Positive
Bowen, 2001
UK
CL
2
(detail)
184
(-)
IV
-
-
184
(-)
-
Negative
Chandy, 1998
USA, France
CL
1
(detail)
141
(-)
IV
-
-
159
(-)
-
Positive
Dror, 1999
Israel
CL
1
(detail)
84
(-)
IV
-
-
102
(-)
-
Positive
Hawi, 1999
Ireland
CL
1
(detail)
170
(-)
IIIR
-
-
217
(-)
-
Negative
Ivkovic, 2006
Serbia
CL
1
(detail)
55
(55%)
IV
22 + 8.1
(-)
37.6 + 10.2
(-)
46
(52%)
36.5 + 6.9
(-)
Positive
Joober, 1999
Canada
CL
1
(detail)
106
(28%)
IV
-
-
93
(53%)
44 + 12
(-)
Negative
Ritsner, 2003
Israel
CL
1
(detail)
147
(22%)
IV
-
-
207
(34%)
33.4 + 6.2
(-)
Positive
Rohrmeier, 1999
Germany
CL
1
(detail)
172
(46%)
IV
-
36.7 + 11.1
(-)
175
(61%)
32.5 + 9.5
(-)
Negative
Wittekindt, 1998
Overlaps with
Chandy, 1998
CL
1
(detail)
117
(-)
IV
-
-
116
(-)
-
n.a.
African Descent
Laurent, 2003
South Africa
CL
1
(detail)
168
(-)
IV
-
-
90
(-)
-
Negative
Asian
Imamura, 2001
Japan
CL
1
(detail)
112
(55%)
M
-
40.9 + 11.4
(-)
102
(58%)
40.2 + 11.3
(-)
Negative
Shen, 2010
China
CL
9
(detail)
893
(44%)
IV
-
50.4 + 13.3
(-)
611
(45%)
41.9 + 9.9
(-)
Negative
Tsai, 1999
Taiwan
CL
1
(detail)
92
(45%)
IV
-
53
(-)
100
(51%)
55
(-)
Negative
Ujike, 2001
Japan
CL
1
(detail)
265
(54%)
10
-
49.8 + 14.3
(-)
100
(65%)
38.2 + 10.9
(-)
Negative
Other/Mixed
Saleem, 2000
India
CL
1
(detail)
59
(42%)
10
21.1 + 6.9
(-)
30.4 + 10.6
(-)
100
(28%)
29.5 + 12.9
(-)
Positive
Contact us
if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
Affecteds
Unaffecteds
Study
Population
# Polys
# Families
# Subjects
(% women)
DX
Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
Comment
Caucasian
Bonnet-Brilhault, 1999
France
1
(detail)
20
62
(-)
IIIR
-
-
60
(-)
-
Negative
Chowdari, 2000
USA
1
(detail)
88
101
(-)
IV
-
-
131
(-)
-
Negative
Meissner, 1999
Germany
5
(detail)
12
35
(-)
IIIR
-
-
63
(-)
-
Negative
Stober, 1998
Germany
1
(detail)
59
59
(41%)
10
23.3 + 8.5
(-)
-
118
(50%)
-
Positive
Wittekindt, 1999
Germany (I)
1
(detail)
49
110
(-)
U
-
-
-
-
Negative
Wittekindt, 1999
Germany (II)
1
(detail)
83
83
(-)
U
-
-
-
-
Negative
African Descent
Laurent, 2003
South Africa
1
(detail)
176
176
(-)
IV
-
-
320
(-)
-
Negative
Asian
Li, 1998
China
1
(detail)
97
97
(41%)
M
-
29.7 + 11.3
(15-65)
194
(50%)
-
Negative
Other/Mixed
Antonarakis, 1999
USA
1
(detail)
54
136
(-)
IV
-
-
166
(-)
-
Negative
Austin, 1999
USA
1
(detail)
187
(-)
IIIR
-
-
53
(-)
-
Negative
Contact us
if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:
Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:
Number of polymorphisms tested per gene and per sample.
Onset Age and Age:
Mean or median age at onset or examination, respectively.
DX:
Criteria used to determine SZ diagnosis -> "IIIR"(DSM-IIIR), "IV" (DSM-IV), "9" (ICD-9), "10" (ICD-10), "M" (Mixed), "RDC" (Research Diagnostic Criteria), "U" (Unknown).
Result:
Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-)
: Either no data provided or in case of overlap, data included in original study.
SZGene Recent Updates
SZGene Stats
Studies: 1727
Genes: 1008
Polymorphisms: 8788
Meta-analyses: 287
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