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SZGene - Gene overview of all published SZ-association studies for PLA2G4A    
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 Gene: PLA2G4A  (PLA2G4; cPLA2-alpha)  Entrez Gene
 Protein: cytosolic phospholipase A2, group IVA  (lysophospholipase; phosphatidylcholine 2-acylhydrolase; calcium-dependent phospholipid-binding protein)  ProteinLink
 Chromosome: 1   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 22 October 2010
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      SZ Cases Normal Controls    
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Barbosa, 2007
Overlaps with
Junqueira, 2004
CL  1  (detail)  75
(57%)
IV--68
(53%)
-n.a.
Chowdari, 2001
USA (I) CL  2  (detail)  74
(46%)
IV-36 + 8.6
(21-62)
74
(-)
-Negative
Doris, 1998
UK CL  1  (detail)  40
(-)
IV-37
(21-63)
40
(-)
35
(22-63)
Negative
Hudson, 1996a
Overlaps with
Hudson, 1996b
CL  1  (detail)  65
(-)
IIIR--65
(68%)
-Positive
Hudson, 1996b
USA, Canada CL  1  (detail)  65
(-)
IIIR--65
(-)
-Positive
Nadalin, 2008
Croatia CL  1  (detail)  81
(47%)
IV26.1 + 7.2
(-)
39.1 + 10.5
(-)
182
(54%)
-Negative
Price, 1997
UK CL  1  (detail)  58
(36%)
IIIR-46
(26-83)
56
(43%)
70
(-)
Negative
Wei, 1998
UK CL  1  (detail)  193
(33%)
U-36.1 + 10.5
(-)
101
(49%)
38.9 + 12.6
(-)
Negative
 African Descent
Chowdari, 2001
USA (II) CL  2  (detail)  20
(170%)
IV-36 + 8.6
(21-62)
20
(-)
-Negative
 Asian
Li, 2007
China CL  1  (detail)  498
(-)
10--299
(-)
-Negative
Pae, 2004
Korea CL  1  (detail)  97
(55%)
IV26.4 + 7.1
(-)
31.5 + 10
(-)
117
(53%)
33 + 11.1
(-)
Positive
 Other/Mixed
Junqueira, 2004
Brazil CL  1  (detail)  240
(43%)
IIIR-34 + 8.6
(-)
312
(52%)
35.5 + 9.9
(-)
Negative
Peet, 1998
India CL  1  (detail)  36
(-)
IV--27
(-)
-Positive
Semwal, 2002
India CL  1  (detail)  536
(44%)
IV-22.8 + 7
(-)
936
(47%)
32.9 + 12.7
(-)
Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds    
Study Population # Polys # Families # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Hudson, 1996a
Italy, Canada  1  (detail)  4444
(-)
IIIR--88
(50%)
-Positive
Hudson, 1996b
Italy, Canada  1  (detail)  3737
(-)
IIIR--72
(-)
-Positive
Mathur, 2009
UK  1  (detail)  221222
(28%)
M-30.5 + 7.9
(-)
352
(58%)
-Trend
Wei, 1998
Overlaps with
Mathur, 2009
 1  (detail)  5050
(-)
U--100
(-)
-n.a.
Wei, 2004
Overlaps with
Mathur, 2009
 3  (detail)  118118
(31%)
U-29 + 6.9
(-)
236
(50%)
-Positive
Wei, 2005
Overlaps with
Mathur, 2009
 1  (detail)  131131
(30%)
U-29.1 + 7.1
(-)
262
(50%)
-n.a.
 Asian
Tao, 2005a
China  1  (detail)  240240
(36%)
10-25.9 + 6.7
(-)
480
(50%)
-Trend
Tao, 2005b
Overlaps with
Tao, 2005a
 1  (detail)  236236
(35%)
10-25.8 + 6.7
(-)
472
(50%)
-n.a.
Yu, 2004
China  2  (detail)  168168
(39%)
10--336
(50%)
-Negative
 Other/Mixed
Chowdari, 2001
USA  2  (detail)  8686
(40%)
IV-36 + 8.6
(21-62)
130
(-)
-Negative
Chowdari, 2001
Overlaps with
Semwal, 2002
 1  (detail)  159159
(40%)
IV-33.3 + 9.2
(16-59)
283
(-)
-n.a.
Chowdari, 2001
India  1  (detail)  159159
(40%)
IV-33.3 + 9.2
(16-59)
283
(-)
-Negative
Frieboes, 2001
Europe, China  1  (detail)   328
(36%)
IIIR-28.4 + 7
(18-49)
426
(-)
-Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine SZ diagnosis ->  "IIIR"(DSM-IIIR), "IV" (DSM-IV), "9" (ICD-9), "10" (ICD-10), "M" (Mixed), "RDC" (Research Diagnostic Criteria), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
SZGene Recent Updates
SZGene Stats
Studies: 1727
Genes: 1008
Polymorphisms: 8788
Meta-analyses: 287
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