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SZGene - Gene overview of all published SZ-association studies for RGS4    
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 Gene: RGS4  (RGP4; SCZD9)  Entrez Gene    View on AlzGene
 Protein: regulator of G-protein signaling 4   ProteinLink
 Chromosome: 1   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 22 October 2010
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      SZ Cases Normal Controls    
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Bakker, 2006
Netherlands CL  2  (detail)  308
(-)
IV--580
(-)
-Positive
Betcheva, 2009
Bulgaria (I) CL  5  (detail)  185
(-)
IV--184
(-)
-Positive
Betcheva, 2009
Bulgaria (II) CL  2  (detail)  70
(-)
IV--372
(-)
-Negative
Chowdari, 2002
USA (I) CO  4  (detail)  93
(-)
U--174
(-)
-Positive
Chowdari, 2007
USA CO  20  (detail)  154
(-)
IIIR--92
(-)
-Negative
Chowdari, 2007
Overlaps with
Chowdari, 2002 USA (I)
CO  4  (detail)  154
(-)
IIIR--92
(-)
-n.a.
Kampman, 2006
Finland CL  1  (detail)  219
(42%)
IV-41.6 + 12.4
(18-76)
389
(46%)
44.5 + 11.1
(19-65)
Negative
Morris, 2004
Ireland CL  4  (detail)  249
(-)
IIIR--231
(-)
-Positive
Nicodemus, 2006
USA CL  5  (detail)  296
(21%)
IV--370
(51%)
-Positive
Nicodemus, 2006
Germany CL  5  (detail)  501
(35%)
IV--627
(52%)
-Positive
Puri, 2006b
Overlaps with
Rizig, 2006
CL  4  (detail)  450
(-)
10--450
(-)
-n.a.
Rethelyi, 2009
Hungary CL  2  (detail)  280
(54%)
IV28.6
(-)
37.6
(-)
230
(57%)
39.9
(-)
Negative
Rizig, 2006
UK CL  4  (detail)  450
(-)
10--450
(-)
-Negative
Sanders, 2008
USA, Australia CL  11  (detail)  1870
(31%)
IV--2002
(53%)
-Negative
Sobell, 2005
USA CL  4  (detail)  568
(-)
IIIR27.4 + 8.9
(-)
38.8 + 10.5
(-)
689
(-)
66.2 + 10.6
(-)
Negative
Vilella, 2007
Spain PO  2  (detail)  589
(31%)
IV--615
(48%)
-Negative
Williams, 2004
UK, Ireland CL  4  (detail)  709
(32%)
IV-46.6 + 14.5
(-)
710
(33%)
44.9 + 12
(-)
Positive
Wood, 2006
USA CL  9  (detail)  311
(-)
IV--291
(-)
-Positive
Zhang, 2005
UK (Scotland) CL  4  (detail)  580
(28%)
M--620
(43%)
-Positive
 African Descent
Chowdari, 2002
USA (II) CO  1  (detail)  70
(-)
U--93
(-)
-Negative
 Asian
Guo, 2006
China CL  6  (detail)  288
(43%)
IV25.8 + 7.5
(-)
46.6 + 10.5
(-)
288
(45%)
-Negative
Ishiguro, 2006
Japan CL  4  (detail)  1918
(45%)
IV-48.9 + 14.5
(-)
1909
(47%)
49 + 14.3
(-)
Negative
So, 2007
China CL  4  (detail)  504
(29%)
IV-41.8 + 10.3
(-)
531
(41%)
41.9 + 9.7
(-)
Trend
 Other/Mixed
Cordeiro, 2005
Brazil CO  4  (detail)  271
(-)
IV--576
(-)
-Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds    
Study Population # Polys # Families # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Chen, 2004
Ireland  4  (detail)  274-IIIR----Trend
Chowdari, 2002
USA  4  (detail)  9393
(-)
U--186
(-)
-Positive
Chowdari, 2007
Overlaps with
Chowdari, 2002 USA (I)
 4  (detail)  154154
(-)
IV--298
(52%)
-n.a.
Chowdari, 2007
USA (NIMH)  20  (detail)  3939
(-)
IV--78
(50%)
-Positive
Chowdari, 2007
Overlaps with
Chowdari, 2007 USA
 20  (detail)  154154
(-)
IV--298
(52%)
-n.a.
Chowdari, 2007
Overlaps with
Chowdari, 2002 USA (NIMH)
 4  (detail)  3939
(-)
IV--78
(50%)
-n.a.
Fallin, 2005
USA  3  (detail)  263274
(26%)
IV19.5 + 4.5
(-)
-548
(50%)
-Positive
Nicodemus, 2006
USA  5  (detail)  296-IV--627
(-)
-Positive
 Asian
Liu, 2006
Taiwan  3  (detail)  218434
(-)
IV--864
(-)
-Negative
Zhang, 2005
China  4  (detail)  322-IV----Negative
 Other/Mixed
Chowdari, 2002
USA (NIMH)  4  (detail)  3939
(-)
IV--186
(-)
-Positive
Chowdari, 2002
India  4  (detail)  341413
(-)
U--538
(-)
-Positive
Cordeiro, 2005
Overlaps wtih Cordeiro, 2005  4  (detail)  4949
(-)
IV--98
(-)
-n.a.
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine SZ diagnosis ->  "IIIR"(DSM-IIIR), "IV" (DSM-IV), "9" (ICD-9), "10" (ICD-10), "M" (Mixed), "RDC" (Research Diagnostic Criteria), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
SZGene Recent Updates
SZGene Stats
Studies: 1727
Genes: 1008
Polymorphisms: 8788
Meta-analyses: 287
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