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SZGene - Gene overview of all published SZ-association studies for IL1B    
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 Gene: IL1B  (IL1F2; IL1-BETA)  Entrez Gene    View on AlzGene   View on MSGene   View on PDGene
 Protein: interleukin 1, beta  (catabolin; preinterleukin 1 beta; pro-interleukin-1-beta)  ProteinLink
 Chromosome: 2   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 22 October 2010
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      SZ Cases Normal Controls    
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Betcheva, 2009
Bulgaria CL  1  (detail)  185
(-)
IV--184
(-)
-Negative
Hanninen, 2007
Finland CL  1  (detail)  113
(39%)
IV23.7 + 6.1
(-)
39.7 + 12
(18-76)
393
(46%)
44.5 + 11.1
(19-65)
Positive
Katila, 1999
Overlaps with
Hanninen, 2007
CL  1  (detail)  50
(-)
IV--400
(-)
-n.a.
Laurent, 1997
France CL  2  (detail)  75
(31%)
IIIR-40.3 + 12.3
(-)
75
(41%)
48.8 + 12.2
(-)
Negative
Meisenzahl, 2001
Germany CL  1  (detail)  44
(0%)
U-30.2 + 8.8
(18-47)
48
(0%)
30.3 + 8.9
(18-47)
Negative
Papiol, 2004
Spain CL  1  (detail)  78
(-)
IV21.2 + 4.6
(-)
31.1 + 7.6
(-)
176
(-)
39.8 + 10.3
(-)
Positive
Saiz, 2006
Spain CL  1  (detail)  228
(39%)
IV26.2 + 9.9
(-)
35.6 + 11.8
(-)
419
(50%)
40.5 + 11.3
(-)
Negative
Shirts, 2006
USA CL  8  (detail)  478
(35%)
IV-38.2 + 9.6
(-)
501
(48%)
-Negative
Zanardini, 2003
Italy CL  1  (detail)  169
(34%)
IV22.8 + 6.5
(-)
42.1 + 12.5
(-)
177
(41%)
54.2 + 13.1
(-)
Positive
 Asian
Chowdari, 2001
China CL  1  (detail)  100
(-)
IV--99
(-)
-Negative
Chowdari, 2001
Singapore CL  1  (detail)  171
(0%)
10--130
(-)
-Negative
Tatsumi, 1997
Japan CL  1  (detail)  54
(-)
IIIR-35 + 11
(19-63)
54
(-)
28 + 7
(19-53)
Negative
Watanabe, 2007
Japan CL  2  (detail)  416
(46%)
IV22.9 + 7.4
(-)
40.5 + 14.7
(-)
440
(48%)
38 + 10.4
(-)
Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds    
Study Population # Polys # Families # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Rosa, 2004
Spain  1  (detail)  8989
(24%)
IV-26.7 + 5.8
(16-42)
267
(-)
-Trend
 Asian
Yang, 2003
China  1  (detail)  132132
(40%)
10--264
(50%)
-Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine SZ diagnosis ->  "IIIR"(DSM-IIIR), "IV" (DSM-IV), "9" (ICD-9), "10" (ICD-10), "M" (Mixed), "RDC" (Research Diagnostic Criteria), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
SZGene Recent Updates
SZGene Stats
Studies: 1727
Genes: 1008
Polymorphisms: 8788
Meta-analyses: 287
ALSGene
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MSGene
PDGene
SZGene
An up-to-date collection of all published genetic association studies.
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