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SZGene - Gene overview of all published SZ-association studies for DAOA    
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 Gene: DAOA  (G72; LG72; SG72)  Entrez Gene
 Protein: D-amino acid oxidase activator  (putative protein LG72; schizophrenia- and bipolar disorder-associated protein G72)  ProteinLink
 Chromosome: 13   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 21 October 2010
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      SZ Cases Normal Controls    
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Bakker, 2006
Netherlands CL  4  (detail)  308
(-)
IV--580
(-)
-Negative
Bass, 2009
UK CL  8  (detail)  431
(-)
M--442
(-)
-Positive
Carrera, 2010
Spain CL  5  (detail)  301
(33%)
IV-52.1 + 15.8
(-)
604
(48%)
37.4 + 12.4
(-)
Negative
Chumakov, 2002
Canada CL  19  (detail)  213
(-)
IV--241
(-)
-Positive
Chumakov, 2002
Russia CL  13  (detail)  183
(-)
IIIR--183
(-)
-Positive
Corvin, 2007
Ireland CL  5  (detail)  373
(-)
IV--812
(-)
-Positive
Jonsson, 2009
Denmark, Norway, Sweden CL  4  (detail)  837
(42%)
M26.5
(-)
45.7
(-)
1473
(42%)
44.1
(-)
Negative
Korostishevsky, 2004
Israel CL  11  (detail)  60
(-)
IV-38.6 + 9.5
(18-65)
130
(-)
-Positive
Ma, 2006
UK (Scotland) CL  6  (detail)  183
(28%)
IIIR25.9 + 13.9
(-)
30.3 + 19.1
(-)
182
(42%)
38.3 + 20.4
(-)
Positive
Nicodemus, 2006
USA CL  6  (detail)  296
(21%)
IV--370
(51%)
-Positive
Opgen-Rhein, 2008
USA CL  11  (detail)  178
(37%)
IV21.8
(-)
37.8 + 10.5
(-)
144
(44%)
42.8 + 13.1
(-)
Positive
Rethelyi, 2009
Hungary CL  2  (detail)  280
(54%)
IV28.6
(-)
37.6
(-)
230
(57%)
39.9
(-)
Negative
Sanders, 2008
USA, Australia CL  29  (detail)  1870
(31%)
IV--2002
(53%)
-Negative
Schumacher, 2004
Germany CL  7  (detail)  299
(49%)
IV-38.6 + 11.9
(-)
300
(60%)
47.1 + 15.2
(-)
Positive
Shinkai, 2007
Canada CL  9  (detail)  168
(-)
IV--168
(-)
-Positive
Vilella, 2007
Spain PO  7  (detail)  589
(31%)
IV--615
(48%)
-Negative
Williams, 2006
UK, Ireland CL  9  (detail)  709
(29%)
IV23.6 + 7.7
(-)
41.8 + 13.5
(-)
1416
(48%)
42.4 + 11.1
(-)
Negative
Wood, 2006
USA CL  19  (detail)  311
(-)
IV--291
(-)
-Negative
 Asian
Ma, 2006
China CL  6  (detail)  588
(46%)
IIIR26.3 + 15
(-)
31.9 + 17.7
(-)
588
(68%)
39 + 20.1
(-)
Positive
Ohi, 2009
Japan CL  8  (detail)  1774
(44%)
IV-45.6 + 15.1
(-)
2092
(51%)
45 + 19.7
(-)
Negative
Shin, 2007
Korea CL  9  (detail)  388
(49%)
IV-42.2 + 8.6
(23-76)
367
(35%)
52.5 + 11
(28-79)
Positive
Wang, 2004
China CL  6  (detail)  537
(47%)
IIIR-41.7 + 17.4
(-)
538
(51%)
38.8 + 15.7
(-)
Positive
Yue, 2006
Overlaps with
Yue, 2007
CL  3  (detail)  216
(44%)
1025.6
(13-53)
30 + 10
(-)
321
(43%)
31 + 11
(-)
n.a.
Yue, 2007
China CL  4  (detail)  359
(45%)
M-29 + 9
(-)
359
(43%)
31 + 11
(-)
Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds    
Study Population # Polys # Families # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Fallin, 2005
USA  14  (detail)  263274
(26%)
IV19.5 + 4.5
(-)
-548
(50%)
-Positive
Goldberg, 2006
USA  11  (detail)  217230
(-)
IV----Negative
Hall, 2004
South Africa  7  (detail)  233-IV----Positive
Hall, 2004
USA  7  (detail)  210210
(-)
IV--420
(50%)
-Positive
Nicodemus, 2006
Overlaps with
Goldberg, 2006
 6  (detail)  296-IV----n.a.
Shinkai, 2007
Canada  9  (detail)  113113
(-)
IV19.5 + 5.6
(-)
-226
(50%)
-Positive
 Asian
Hong, 2006
Taiwan  1  (detail)  216216
(43%)
IV-30.3 + 8.2
(-)
432
(50%)
-Positive
Liu, 2006
Taiwan  11  (detail)  218-IV----Negative
Ma, 2009
China  3  (detail)  126-IV----Positive
Shi, 2008
China  2  (detail)  4371116
(36%)
IV--661
(-)
-Positive
Yue, 2007
China  4  (detail)  237237
(44%)
M-31 + 7
(-)
474
(50%)
-Positive
Zou, 2005
China  3  (detail)  223223
(-)
IIIR--446
(50%)
-Positive
 Other/Mixed
Addington, 2004
USA  8  (detail)  9898
(-)
M----Positive
Korostishevsky, 2006
Palestine (I)  11  (detail)  5656
(43%)
IV22
(14-45)
-112
(50%)
-Positive
Korostishevsky, 2006
Palestine (II)  11  (detail)  136136
(22%)
IV24.5
(17-32)
-272
(50%)
-Positive
Korostishevsky, 2006
Palestine (III)  11  (detail)  3131
(35%)
IV23
(16-35)
-62
(50%)
-Positive
Mulle, 2005
USA  13  (detail)  159159
(-)
U--318
(50%)
-Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine SZ diagnosis ->  "IIIR"(DSM-IIIR), "IV" (DSM-IV), "9" (ICD-9), "10" (ICD-10), "M" (Mixed), "RDC" (Research Diagnostic Criteria), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
SZGene Recent Updates
SZGene Stats
Studies: 1727
Genes: 1008
Polymorphisms: 8788
Meta-analyses: 287
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