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SZGene - Gene overview of all published SZ-association studies for NOTCH4    
Back Search Methods Disclaimer Credits
 Gene: NOTCH4  (INT3)  Entrez Gene    View on AlzGene   View on MSGene
 Protein: notch4   ProteinLink
 Chromosome: 6   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 22 October 2010
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      SZ Cases Normal Controls    
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Anttila, 2003
Finland CL  1  (detail)  94
(51%)
IV29.6 + 10.1
(-)
46 + 11.1
(-)
94
(-)
-Negative
Anttila, 2004
Overlaps with
Anttila, 2003
CL  1  (detail)  94
(51%)
IV--98
(-)
-n.a.
Betcheva, 2009
Bulgaria (I) CL  4  (detail)  185
(-)
IV--184
(-)
-Positive
Betcheva, 2009
Bulgaria (II) CL  2  (detail)  70
(-)
IV--372
(-)
-Negative
Carmine, 2003
Sweden CL  2  (detail)  74
(39%)
IIIR--135
(33%)
-Negative
Ikeda, 2010
UK (published GWAS) CL  1  (detail)  479
(-)
U--2938
(-)
-Negative
ISC, 2009
UK (London; GWAS) CL  1  (detail)  523
(29%)
M--505
(58%)
-Positive
ISC, 2009
Ireland (GWAS) CL  1  (detail)  275
(31%)
M--866
(70%)
-Positive
ISC, 2009
Portugal (GWAS) CL  1  (detail)  347
(38%)
M--216
(63%)
-Positive
ISC, 2009
Sweden-I (GWAS) CL  1  (detail)  170
(-)
M--170
(-)
-Positive
ISC, 2009
Sweden-II (GWAS) CL  1  (detail)  390
(-)
M--230
(-)
-Positive
ISC, 2009
UK (Aberdeen; GWAS) CL  1  (detail)  720
(26%)
M--702
(36%)
-Positive
ISC, 2009
UK (Edinburgh; GWAS) CL  1  (detail)  369
(27%)
M--287
(48%)
-Positive
ISC, 2009
Bulgaria (GWAS) CL  1  (detail)  528
(49%)
M--611
(52%)
-Positive
Ivo, 2006
Germany CL  10  (detail)  512
(-)
IIIR--232
(69%)
-Negative
Luo, 2004
USA CL  2  (detail)  223
(-)
IIIR--211
(-)
-Negative
McGinnis, 2001
UK (Scotland) CL  2  (detail)  324
(-)
U--692
(-)
-Negative
Sklar, 2001
UK PO  3  (detail)  142
(-)
IV--161
(67%)
-Negative
Stefansson, 2009
Italy (GWAS) CL  1  (detail)  84
(-)
10--89
(-)
-Negative
Stefansson, 2009
Netherlands-I (Follow-up) CL  1  (detail)  715
(-)
IV--3634
(-)
-Negative
Stefansson, 2009
Norway (Follow-up) CL  1  (detail)  114
(-)
M--170
(-)
-Negative
Stefansson, 2009
UK (England; GWAS) CL  1  (detail)  93
(-)
10--88
(-)
-Negative
Stefansson, 2009
Russia (Follow-up) CL  1  (detail)  484
(-)
IV--491
(-)
-Trend
Stefansson, 2009
Spain (Santiago; Follow-up) CL  1  (detail)  296
(-)
IV--625
(-)
-Negative
Stefansson, 2009
Spain (Valencia; Follow-up) CL  1  (detail)  371
(-)
IV--417
(-)
-Negative
Stefansson, 2009
Sweden (Follow-up) CL  1  (detail)  255
(-)
M--293
(-)
-Trend
Stefansson, 2009
Denmark (Aarhus; Follow-up) CL  1  (detail)  680
(-)
M--1110
(-)
-Negative
Stefansson, 2009
Denmark (Copenhagen; Follow-up) CL  1  (detail)  513
(-)
10--1339
(-)
-Positive
Stefansson, 2009
Finland (Follow-up) CL  1  (detail)  287
(-)
IV--3987
(-)
-Trend
Stefansson, 2009
Finland (Helsinki; GWAS) CL  1  (detail)  59
(-)
IV--147
(-)
-Positive
Stefansson, 2009
Finland (Kuusamo; GWAS) CL  1  (detail)  123
(-)
IV--50
(-)
-Negative
Stefansson, 2009
Germany (Bonn; Follow-up) CL  1  (detail)  618
(-)
IV--1550
(-)
-Negative
Stefansson, 2009
Germany (Bonn; GWAS) CL  1  (detail)  483
(-)
IV--367
(-)
-Trend
Stefansson, 2009
Germany (Munich; Follow-up) CL  1  (detail)  303
(-)
IV--1625
(-)
-Positive
Stefansson, 2009
Germany (Munich; GWAS) CL  1  (detail)  574
(-)
IV--604
(-)
-Negative
Stefansson, 2009
Hungary (Follow-up) CL  1  (detail)  272
(-)
IV--227
(-)
-Negative
Stefansson, 2009
Iceland (GWAS) CL  1  (detail)  589
(-)
M--11492
(-)
-Negative
Stefansson, 2009
UK (Scotland; GWAS) CL  1  (detail)  658
(-)
M--661
(-)
-Positive
Stefansson, 2009
Netherlands-II (Follow-up) CL  1  (detail)  91
(-)
IV--87
(-)
-Negative
 African Descent
Luo, 2004
USA, Canada CL  2  (detail)  123
(-)
IIIR--85
(-)
-Positive
 Asian
Fan, 2002
China CL  5  (detail)  544
(47%)
IIIR-42 + 16.5
(-)
621
(50%)
41.5 + 16.1
(-)
Negative
Ikeda, 2010
Japan (GWAS) CL  2  (detail)  575
(-)
IV-43.5 + 14.8
(-)
564
(-)
44 + 14.4
(-)
Positive
Ikeda, 2010
Japan (REP) CL  2  (detail)  1511
(-)
IV-45.9 + 14
(-)
1517
(-)
46 + 14.6
(-)
Positive
Imai, 2001
Japan CL  1  (detail)  102
(40%)
IV25.9 + 8.7
(-)
46.7 + 13.4
(-)
100
(70%)
39.8 + 11.8
(-)
Negative
Kaneko, 2004
Japan CL  5  (detail)  235
(48%)
IV30 + 9.4
(-)
46 + 13.3
(-)
235
(48%)
42.8 + 10.8
(-)
Negative
Li, 2010
China CL  1  (detail)  2496
(45%)
IV25.6 + 8.1
(-)
-5184
(48%)
56.2 + 12.8
(-)
Positive
Shibata, 2006
Japan CL  3  (detail)  191
(47%)
IV-40.6 + 13.7
(17-47)
133
(53%)
51.5 + 18.4
(28-58)
Negative
Tochigi, 2004
Japan CL  6  (detail)  284
(43%)
IV-46.1 + 14.6
(-)
284
(43%)
40.1 + 11.5
(-)
Negative
Tochigi, 2007
Japan CL  4  (detail)  241
(43%)
IV-46.2 + 14.8
(-)
290
(43%)
41.6 + 11.6
(-)
Trend
Tochigi, 2007
Overlaps with
Tochigi, 2004
CL  3  (detail)  241
(43%)
IV-46.2 + 14.8
(-)
290
(43%)
41.6 + 11.6
(-)
n.a.
Ujike, 2001
Japan CL  3  (detail)  188
(42%)
10-44.7 + 14
(-)
143
(56%)
42.6 + 15.1
(-)
Negative
 Other/Mixed
Wassink, 2003
USA CL  1  (detail)  210
(26%)
M-28.5 + 9.2
(-)
85
(49%)
28.4 + 7.8
(-)
Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds    
Study Population # Polys # Families # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Ivo, 2006
Germany  10  (detail)  159159
(-)
IIIR--318
(50%)
-Negative
Prasad, 2004
USA  5  (detail)  148148
(-)
IV--296
(50%)
-Positive
Sklar, 2001
Bulgaria  3  (detail)  108108
(-)
IV--216
(50%)
-Negative
Sklar, 2001
Germany (I)  3  (detail)  251251
(-)
IV--502
(50%)
-Negative
Skol, 2003
USA (II)  5  (detail)  62-IIIR----Negative
Wei, 2000
UK  5  (detail)  8080
(-)
U--160
(50%)
-Positive
 African Descent
Skol, 2003
USA (I)  5  (detail)  60-IIIR----Positive
 Asian
Fan, 2002
China  5  (detail)  327327
(45%)
IIIR-25.8 + 7.7
(-)
654
(50%)
-Negative
Kaneko, 2004
Japan  5  (detail)  7878
(44%)
IV30 + 9.4
(-)
-156
(50%)
-Negative
Liu, 2006
Taiwan  7  (detail)  218461
(38%)
IV22.2 + 6.2
(-)
34.5 + 9.4
(-)
403
(53%)
52.6 + 15.3
(-)
Positive
Proitsi, 2008
China  2  (detail)  307307
(50%)
IV--614
(50%)
-Negative
Takahashi, 2003
Japan, China  6  (detail)  123123
(50%)
IV22.9 + 5.4
(-)
29.5 + 5.7
(-)
246
(50%)
60.5 + 7.3
(-)
Negative
Wang, 2006
China  4  (detail)  282282
(36%)
10-25.5 + 6.7
(-)
564
(50%)
-Positive
Zhang, 2004
Overlaps with
Wang, 2006
 4  (detail)  141141
(-)
10--182
(77%)
-Positive
 Other/Mixed
Ivo, 2006
Palestine  10  (detail)  208208
(-)
IV--416
(50%)
-Negative
Miranda, 2006
Colombia  1  (detail)  110-IV----Negative
Prasad, 2004
India  5  (detail)  182182
(-)
IV--364
(50%)
-Positive
Sklar, 2001
Germany (II)  3  (detail)  160160
(-)
IV--160
(-)
-Negative
Skol, 2003
USA (III)  5  (detail)  44-IIIR----Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine SZ diagnosis ->  "IIIR"(DSM-IIIR), "IV" (DSM-IV), "9" (ICD-9), "10" (ICD-10), "M" (Mixed), "RDC" (Research Diagnostic Criteria), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
SZGene Recent Updates
SZGene Stats
Studies: 1727
Genes: 1008
Polymorphisms: 8788
Meta-analyses: 287
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