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Printable version
SZGene - Gene overview of all published SZ-association studies for NOTCH4
Gene:
NOTCH4
(INT3)
View on AlzGene
View on MSGene
Protein:
notch4
Chromosome:
6
(View:
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
X
Y
MT
)
Status:
Updated 22 October 2010
1. Case-Control Studies (by ethnic group)
SZ Cases
Normal Controls
Study
Population
Source
# Polys
# Subjects
(% women)
DX
Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
Comment
Caucasian
Anttila, 2003
Finland
CL
1
(detail)
94
(51%)
IV
29.6 + 10.1
(-)
46 + 11.1
(-)
94
(-)
-
Negative
Anttila, 2004
Overlaps with
Anttila, 2003
CL
1
(detail)
94
(51%)
IV
-
-
98
(-)
-
n.a.
Betcheva, 2009
Bulgaria (I)
CL
4
(detail)
185
(-)
IV
-
-
184
(-)
-
Positive
Betcheva, 2009
Bulgaria (II)
CL
2
(detail)
70
(-)
IV
-
-
372
(-)
-
Negative
Carmine, 2003
Sweden
CL
2
(detail)
74
(39%)
IIIR
-
-
135
(33%)
-
Negative
Ikeda, 2010
UK (published GWAS)
CL
1
(detail)
479
(-)
U
-
-
2938
(-)
-
Negative
ISC, 2009
UK (London; GWAS)
CL
1
(detail)
523
(29%)
M
-
-
505
(58%)
-
Positive
ISC, 2009
Ireland (GWAS)
CL
1
(detail)
275
(31%)
M
-
-
866
(70%)
-
Positive
ISC, 2009
Portugal (GWAS)
CL
1
(detail)
347
(38%)
M
-
-
216
(63%)
-
Positive
ISC, 2009
Sweden-I (GWAS)
CL
1
(detail)
170
(-)
M
-
-
170
(-)
-
Positive
ISC, 2009
Sweden-II (GWAS)
CL
1
(detail)
390
(-)
M
-
-
230
(-)
-
Positive
ISC, 2009
UK (Aberdeen; GWAS)
CL
1
(detail)
720
(26%)
M
-
-
702
(36%)
-
Positive
ISC, 2009
UK (Edinburgh; GWAS)
CL
1
(detail)
369
(27%)
M
-
-
287
(48%)
-
Positive
ISC, 2009
Bulgaria (GWAS)
CL
1
(detail)
528
(49%)
M
-
-
611
(52%)
-
Positive
Ivo, 2006
Germany
CL
10
(detail)
512
(-)
IIIR
-
-
232
(69%)
-
Negative
Luo, 2004
USA
CL
2
(detail)
223
(-)
IIIR
-
-
211
(-)
-
Negative
McGinnis, 2001
UK (Scotland)
CL
2
(detail)
324
(-)
U
-
-
692
(-)
-
Negative
Sklar, 2001
UK
PO
3
(detail)
142
(-)
IV
-
-
161
(67%)
-
Negative
Stefansson, 2009
Italy (GWAS)
CL
1
(detail)
84
(-)
10
-
-
89
(-)
-
Negative
Stefansson, 2009
Netherlands-I (Follow-up)
CL
1
(detail)
715
(-)
IV
-
-
3634
(-)
-
Negative
Stefansson, 2009
Norway (Follow-up)
CL
1
(detail)
114
(-)
M
-
-
170
(-)
-
Negative
Stefansson, 2009
UK (England; GWAS)
CL
1
(detail)
93
(-)
10
-
-
88
(-)
-
Negative
Stefansson, 2009
Russia (Follow-up)
CL
1
(detail)
484
(-)
IV
-
-
491
(-)
-
Trend
Stefansson, 2009
Spain (Santiago; Follow-up)
CL
1
(detail)
296
(-)
IV
-
-
625
(-)
-
Negative
Stefansson, 2009
Spain (Valencia; Follow-up)
CL
1
(detail)
371
(-)
IV
-
-
417
(-)
-
Negative
Stefansson, 2009
Sweden (Follow-up)
CL
1
(detail)
255
(-)
M
-
-
293
(-)
-
Trend
Stefansson, 2009
Denmark (Aarhus; Follow-up)
CL
1
(detail)
680
(-)
M
-
-
1110
(-)
-
Negative
Stefansson, 2009
Denmark (Copenhagen; Follow-up)
CL
1
(detail)
513
(-)
10
-
-
1339
(-)
-
Positive
Stefansson, 2009
Finland (Follow-up)
CL
1
(detail)
287
(-)
IV
-
-
3987
(-)
-
Trend
Stefansson, 2009
Finland (Helsinki; GWAS)
CL
1
(detail)
59
(-)
IV
-
-
147
(-)
-
Positive
Stefansson, 2009
Finland (Kuusamo; GWAS)
CL
1
(detail)
123
(-)
IV
-
-
50
(-)
-
Negative
Stefansson, 2009
Germany (Bonn; Follow-up)
CL
1
(detail)
618
(-)
IV
-
-
1550
(-)
-
Negative
Stefansson, 2009
Germany (Bonn; GWAS)
CL
1
(detail)
483
(-)
IV
-
-
367
(-)
-
Trend
Stefansson, 2009
Germany (Munich; Follow-up)
CL
1
(detail)
303
(-)
IV
-
-
1625
(-)
-
Positive
Stefansson, 2009
Germany (Munich; GWAS)
CL
1
(detail)
574
(-)
IV
-
-
604
(-)
-
Negative
Stefansson, 2009
Hungary (Follow-up)
CL
1
(detail)
272
(-)
IV
-
-
227
(-)
-
Negative
Stefansson, 2009
Iceland (GWAS)
CL
1
(detail)
589
(-)
M
-
-
11492
(-)
-
Negative
Stefansson, 2009
UK (Scotland; GWAS)
CL
1
(detail)
658
(-)
M
-
-
661
(-)
-
Positive
Stefansson, 2009
Netherlands-II (Follow-up)
CL
1
(detail)
91
(-)
IV
-
-
87
(-)
-
Negative
African Descent
Luo, 2004
USA, Canada
CL
2
(detail)
123
(-)
IIIR
-
-
85
(-)
-
Positive
Asian
Fan, 2002
China
CL
5
(detail)
544
(47%)
IIIR
-
42 + 16.5
(-)
621
(50%)
41.5 + 16.1
(-)
Negative
Ikeda, 2010
Japan (GWAS)
CL
2
(detail)
575
(-)
IV
-
43.5 + 14.8
(-)
564
(-)
44 + 14.4
(-)
Positive
Ikeda, 2010
Japan (REP)
CL
2
(detail)
1511
(-)
IV
-
45.9 + 14
(-)
1517
(-)
46 + 14.6
(-)
Positive
Imai, 2001
Japan
CL
1
(detail)
102
(40%)
IV
25.9 + 8.7
(-)
46.7 + 13.4
(-)
100
(70%)
39.8 + 11.8
(-)
Negative
Kaneko, 2004
Japan
CL
5
(detail)
235
(48%)
IV
30 + 9.4
(-)
46 + 13.3
(-)
235
(48%)
42.8 + 10.8
(-)
Negative
Li, 2010
China
CL
1
(detail)
2496
(45%)
IV
25.6 + 8.1
(-)
-
5184
(48%)
56.2 + 12.8
(-)
Positive
Shibata, 2006
Japan
CL
3
(detail)
191
(47%)
IV
-
40.6 + 13.7
(17-47)
133
(53%)
51.5 + 18.4
(28-58)
Negative
Tochigi, 2004
Japan
CL
6
(detail)
284
(43%)
IV
-
46.1 + 14.6
(-)
284
(43%)
40.1 + 11.5
(-)
Negative
Tochigi, 2007
Japan
CL
4
(detail)
241
(43%)
IV
-
46.2 + 14.8
(-)
290
(43%)
41.6 + 11.6
(-)
Trend
Tochigi, 2007
Overlaps with
Tochigi, 2004
CL
3
(detail)
241
(43%)
IV
-
46.2 + 14.8
(-)
290
(43%)
41.6 + 11.6
(-)
n.a.
Ujike, 2001
Japan
CL
3
(detail)
188
(42%)
10
-
44.7 + 14
(-)
143
(56%)
42.6 + 15.1
(-)
Negative
Other/Mixed
Wassink, 2003
USA
CL
1
(detail)
210
(26%)
M
-
28.5 + 9.2
(-)
85
(49%)
28.4 + 7.8
(-)
Negative
Contact us
if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
Affecteds
Unaffecteds
Study
Population
# Polys
# Families
# Subjects
(% women)
DX
Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
Comment
Caucasian
Ivo, 2006
Germany
10
(detail)
159
159
(-)
IIIR
-
-
318
(50%)
-
Negative
Prasad, 2004
USA
5
(detail)
148
148
(-)
IV
-
-
296
(50%)
-
Positive
Sklar, 2001
Bulgaria
3
(detail)
108
108
(-)
IV
-
-
216
(50%)
-
Negative
Sklar, 2001
Germany (I)
3
(detail)
251
251
(-)
IV
-
-
502
(50%)
-
Negative
Skol, 2003
USA (II)
5
(detail)
62
-
IIIR
-
-
-
-
Negative
Wei, 2000
UK
5
(detail)
80
80
(-)
U
-
-
160
(50%)
-
Positive
African Descent
Skol, 2003
USA (I)
5
(detail)
60
-
IIIR
-
-
-
-
Positive
Asian
Fan, 2002
China
5
(detail)
327
327
(45%)
IIIR
-
25.8 + 7.7
(-)
654
(50%)
-
Negative
Kaneko, 2004
Japan
5
(detail)
78
78
(44%)
IV
30 + 9.4
(-)
-
156
(50%)
-
Negative
Liu, 2006
Taiwan
7
(detail)
218
461
(38%)
IV
22.2 + 6.2
(-)
34.5 + 9.4
(-)
403
(53%)
52.6 + 15.3
(-)
Positive
Proitsi, 2008
China
2
(detail)
307
307
(50%)
IV
-
-
614
(50%)
-
Negative
Takahashi, 2003
Japan, China
6
(detail)
123
123
(50%)
IV
22.9 + 5.4
(-)
29.5 + 5.7
(-)
246
(50%)
60.5 + 7.3
(-)
Negative
Wang, 2006
China
4
(detail)
282
282
(36%)
10
-
25.5 + 6.7
(-)
564
(50%)
-
Positive
Zhang, 2004
Overlaps with
Wang, 2006
4
(detail)
141
141
(-)
10
-
-
182
(77%)
-
Positive
Other/Mixed
Ivo, 2006
Palestine
10
(detail)
208
208
(-)
IV
-
-
416
(50%)
-
Negative
Miranda, 2006
Colombia
1
(detail)
110
-
IV
-
-
-
-
Negative
Prasad, 2004
India
5
(detail)
182
182
(-)
IV
-
-
364
(50%)
-
Positive
Sklar, 2001
Germany (II)
3
(detail)
160
160
(-)
IV
-
-
160
(-)
-
Negative
Skol, 2003
USA (III)
5
(detail)
44
-
IIIR
-
-
-
-
Negative
Contact us
if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:
Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:
Number of polymorphisms tested per gene and per sample.
Onset Age and Age:
Mean or median age at onset or examination, respectively.
DX:
Criteria used to determine SZ diagnosis -> "IIIR"(DSM-IIIR), "IV" (DSM-IV), "9" (ICD-9), "10" (ICD-10), "M" (Mixed), "RDC" (Research Diagnostic Criteria), "U" (Unknown).
Result:
Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-)
: Either no data provided or in case of overlap, data included in original study.
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Genes: 1008
Polymorphisms: 8788
Meta-analyses: 287
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