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SZGene - Gene overview of all published SZ-association studies for KCNH2    
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 Gene: KCNH2  (ERG1; HERG; HERG1; Kv11.1; LQT2; SQT1)  Entrez Gene    View on MSGene
 Protein: potassium voltage-gated channel, subfamily H (eag-related), member 2  (ether-a-go-go-related potassium channel protein; potassium voltage-gated channel subfamily H member 2; voltage-gated potassium channel, subfamily H, member 2)  ProteinLink
 Chromosome: 7   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 20 July 2010
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      SZ Cases Normal Controls    
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Huffaker, 2009
Germany CL  7  (detail)  905
(-)
U--1323
(-)
-Positive
Huffaker, 2009
Armenia CL  7  (detail)  160
(-)
10--162
(-)
-Negative
Huffaker, 2009
Italy CL  7  (detail)  72
(-)
IV--123
(-)
-Negative
 Other/Mixed
Atalar, 2010
Turkey (males) CL  4  (detail)  84
(0%)
IV--74
(0%)
34.3 + 8.1
(-)
Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds    
Study Population # Polys # Families # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Huffaker, 2009
USA (NIMHGI)  34  (detail)  71-U----Positive
Huffaker, 2009
USA (CBDB)  36  (detail)  296-U----Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine SZ diagnosis ->  "IIIR"(DSM-IIIR), "IV" (DSM-IV), "9" (ICD-9), "10" (ICD-10), "M" (Mixed), "RDC" (Research Diagnostic Criteria), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
SZGene Recent Updates
SZGene Stats
Studies: 1727
Genes: 1008
Polymorphisms: 8788
Meta-analyses: 287
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An up-to-date collection of all published genetic association studies.
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