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Summary of putative genetic linkage regions for schizophrenia based on meta-analysis by Ng et al. (2009)
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Chromosome Location (Mb) P-value
1p32.2-31.1 57.3-84.6 0.027 (ALL)
1p13.2-q23.3* 114.6-162.1 0.008 (ALL)
2q12.1-21.2* 103.3-134.0 0.0076 (ALL)
2q21.2-31.1* 134.0-169.9 0.024 (ALL)
2q33.3-36.3 206.3-228.3 0.009 (ALL), 0.010 (CAUC)
3p14.1-q13.32 71.6-120.2 0.041 (ALL), 0.044 (CAUC)
5q31.3-35.1* 141.8-167.7 0.0046 (ALL), 0.017 (CAUC)
5q35.1-35.3 167.7-180.4 0.028 (ALL)
6p21.31-12.1 33.9-56.6 0.044 (CAUC)
8p22-12* 15.7-32.7 0.031 (ALL), 0.0006 (CAUC)
10q26.12-26.3 123.1-135.1 0.035 (ALL)
16p13.12-q12.2* 13.2-51.5 0.018 (CAUC)

Linkage regions in this table are based on nominally significant results of the meta-analysis of genome-wide linkage (GWL) scans performed by Ng et al (2009), in particular the results summarized in Tables 2 and 3 of that paper. This meta-analysis represents an updated, refined version of the GWL meta-analysis of the same group (Lewis et al., 2003), the results of which were displayed here previously. Meta-analysis (using the Genome Search Meta-Analysis [GSMA] method) was applied to data from a total of 32 published GWL scans across 3255 pedigrees including 7413 affected individuals. The GSMA included scans that typed DNA markers at 30 cM or finer density throughout the genome in non-overlapping samples with at least 30 probands diagnosed with schizophrenia or schizoaffective disorder. The approximate chromosomal intervals of these loci are indicated by a red line on the respective chromosome graphs throughout SzGene (example).

Asterisks indicate which regions were consistent with the previous GSMA of Lewis et al (2003). “P-value” refers to the summed rank P-value as given in Ng et al (2009). Bold P-values indicate regions with genome-wide suggestive evidence for linkage (P <0.0078). “ALL” denotes P-values for meta-analyses including samples irrespective of ethnic descent, “CAUC” indicates P-values for Caucasian samples only. Please consult the paper by Ng et al (2009) for more details.

References

Ng MY, et al (2009). “Meta-analysis of 32 genome-wide linkage studies of schizophrenia.” Mol Psychiatry. 2009 Aug;14(8):774-85.

Lewis CM, et al. (2003) "Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia." Am J Hum Genet 73:34-38.

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