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Printable version  
Polymorphism Details     
Back Search Methods Disclaimer Credits
 Study: Fatemi, 2008
 Gene: PDE4B  (DPDE4; PDEIVB)  Entrez Gene    View on MSGene
 Protein: phosphodiesterase 4B, cAMP-specific  (phosphodiesterase; dunce-like phosphodiesterase E4)  ProteinLink
 Chromosome: 1   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 22 October 2010
Meta-Analysis     Gene Overview
Total number of polymorphisms investigated by this study: 27

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele T-Allele G/G
(frequency)		 G/T
(frequency)		 T/T
(frequency)
 African Descent
rs4454519 USA SZ
CTR		 0.11
0.08		 0.89
0.92		 3 (0.013)
1 (0.005)		 45 (0.192)
31 (0.158)		 186 (0.795)
164 (0.837)
 Caucasian
rs4454519 USA SZ
CTR		 0.18
0.18		 0.82
0.82		 22 (0.034)
13 (0.032)		 193 (0.300)
121 (0.297)		 429 (0.666)
273 (0.671)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   m-Allele M-Allele m/m
(frequency)		 m/M
(frequency)		 M/M
(frequency)
 African Descent
rs6588174 USA SZ
CTR		 0.76
0.73		 0.24
0.27		 136 (0.581)
107 (0.540)		 85 (0.363)
77 (0.389)		 13 (0.056)
14 (0.071)
 Caucasian
rs6588174 USA SZ
CTR		 0.49
0.51		 0.51
0.49		 157 (0.243)
107 (0.263)		 322 (0.499)
203 (0.499)		 166 (0.257)
97 (0.238)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   m-Allele M-Allele m/m
(frequency)		 m/M
(frequency)		 M/M
(frequency)
 African Descent
rs1392812 USA SZ
CTR		 0.37
0.38		 0.63
0.62		 32 (0.137)
28 (0.142)		 109 (0.466)
92 (0.467)		 93 (0.397)
77 (0.391)
 Caucasian
rs1392812 USA SZ
CTR		 0.46
0.45		 0.54
0.55		 134 (0.208)
83 (0.203)		 320 (0.496)
202 (0.495)		 191 (0.296)
123 (0.301)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   m-Allele M-Allele m/m
(frequency)		 m/M
(frequency)		 M/M
(frequency)
 African Descent
rs2503166 USA SZ
CTR		 0.31
0.31		 0.69
0.69		 23 (0.098)
19 (0.096)		 100 (0.427)
84 (0.426)		 111 (0.474)
94 (0.477)
 Caucasian
rs2503166 USA SZ
CTR		 0.28
0.29		 0.72
0.71		 52 (0.081)
34 (0.084)		 262 (0.407)
168 (0.413)		 329 (0.512)
205 (0.504)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele A-Allele C/C
(frequency)		 C/A
(frequency)		 A/A
(frequency)
 African Descent
rs583018 USA SZ
CTR		 0.70
0.71		 0.30
0.29		 114 (0.489)
98 (0.497)		 98 (0.421)
82 (0.416)		 21 (0.090)
17 (0.086)
 Caucasian
rs583018 USA SZ
CTR		 0.34
0.32		 0.66
0.68		 75 (0.116)
41 (0.101)		 290 (0.450)
177 (0.435)		 279 (0.433)
189 (0.464)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   m-Allele M-Allele m/m
(frequency)		 m/M
(frequency)		 M/M
(frequency)
 African Descent
rs1572680 USA SZ
CTR		 0.17
0.20		 0.83
0.80		 7 (0.030)
8 (0.041)		 67 (0.286)
62 (0.315)		 160 (0.684)
127 (0.645)
 Caucasian
rs1572680 USA SZ
CTR		 0.50
0.54		 0.50
0.46		 160 (0.248)
120 (0.295)		 322 (0.500)
202 (0.496)		 162 (0.252)
85 (0.209)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 African Descent
rs599381 USA SZ
CTR		 0.07
0.03		 0.93
0.97		 1 (0.004)
0 (0.000)		 32 (0.137)
11 (0.056)		 200 (0.858)
186 (0.944)
 Caucasian
rs599381 USA SZ
CTR		 0.22
0.20		 0.78
0.80		 32 (0.050)
17 (0.042)		 223 (0.346)
132 (0.324)		 389 (0.604)
259 (0.635)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele T-Allele A/A
(frequency)		 A/T
(frequency)		 T/T
(frequency)
 African Descent
rs1040716 USA SZ
CTR		 0.84
0.88		 0.16
0.12		 166 (0.709)
155 (0.783)		 62 (0.265)
40 (0.202)		 6 (0.026)
3 (0.015)
 Caucasian
rs1040716 USA SZ
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele A-Allele C/C
(frequency)		 C/A
(frequency)		 A/A
(frequency)
 African Descent
rs2144719 USA SZ
CTR		 0.09
0.10		 0.91
0.90		 2 (0.009)
2 (0.010)		 37 (0.158)
36 (0.183)		 195 (0.833)
159 (0.807)
 Caucasian
rs2144719 USA SZ
CTR		 0.36
0.44		 0.64
0.56		 83 (0.129)
78 (0.192)		 296 (0.460)
200 (0.491)		 265 (0.411)
129 (0.317)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele G-Allele T/T
(frequency)		 T/G
(frequency)		 G/G
(frequency)
 African Descent
rs4004 USA SZ
CTR		 0.09
0.09		 0.91
0.91		 2 (0.009)
2 (0.010)		 40 (0.171)
32 (0.162)		 192 (0.821)
163 (0.827)
 Caucasian
rs4004 USA SZ
CTR		 0.35
0.37		 0.65
0.63		 80 (0.124)
55 (0.135)		 294 (0.457)
190 (0.467)		 270 (0.419)
162 (0.398)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 African Descent
rs4320761 USA SZ
CTR		 0.44
0.42		 0.56
0.58		 45 (0.192)
35 (0.178)		 115 (0.491)
96 (0.487)		 74 (0.316)
66 (0.335)
 Caucasian
rs4320761 USA SZ
CTR		 0.07
0.04		 0.93
0.96		 3 (0.005)
1 (0.002)		 82 (0.127)
32 (0.079)		 559 (0.868)
374 (0.919)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 African Descent
rs910694 USA SZ
CTR		 0.72
0.77		 0.28
0.23		 121 (0.519)
118 (0.599)		 94 (0.403)
69 (0.350)		 18 (0.077)
10 (0.051)
 Caucasian
rs910694 USA SZ
CTR		 0.44
0.50		 0.56
0.50		 126 (0.196)
102 (0.250)		 318 (0.494)
204 (0.500)		 200 (0.311)
102 (0.250)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele A-Allele C/C
(frequency)		 C/A
(frequency)		 A/A
(frequency)
 African Descent
rs1321177 USA SZ
CTR		 0.31
0.32		 0.69
0.68		 22 (0.094)
20 (0.102)		 100 (0.427)
86 (0.437)		 112 (0.479)
91 (0.462)
 Caucasian
rs1321177 USA SZ
CTR		 0.30
0.37		 0.70
0.63		 56 (0.087)
56 (0.138)		 268 (0.417)
190 (0.467)		 319 (0.496)
161 (0.396)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele C-Allele A/A
(frequency)		 A/C
(frequency)		 C/C
(frequency)
 African Descent
rs4077431 USA SZ
CTR		 0.48
0.42		 0.52
0.58		 55 (0.234)
35 (0.178)		 117 (0.498)
96 (0.487)		 63 (0.268)
66 (0.335)
 Caucasian
rs4077431 USA SZ
CTR		 0.41
0.42		 0.59
0.58		 108 (0.168)
72 (0.177)		 311 (0.483)
198 (0.486)		 225 (0.349)
137 (0.337)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 African Descent
rs7547294 USA SZ
CTR		 0.41
0.48		 0.59
0.52		 40 (0.171)
46 (0.235)		 114 (0.487)
98 (0.500)		 80 (0.342)
52 (0.265)
 Caucasian
rs7547294 USA SZ
CTR		 0.49
0.50		 0.51
0.50		 155 (0.240)
100 (0.246)		 322 (0.499)
203 (0.500)		 168 (0.260)
103 (0.254)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 African Descent
rs783038 USA SZ
CTR		 0.07
0.08		 0.93
0.92		 1 (0.004)
1 (0.005)		 32 (0.137)
30 (0.152)		 201 (0.859)
166 (0.843)
 Caucasian
rs783038 USA SZ
CTR		 0.25
0.30		 0.75
0.70		 40 (0.062)
36 (0.088)		 241 (0.374)
170 (0.417)		 363 (0.564)
202 (0.495)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 African Descent
rs7519259 USA SZ
CTR		 0.19
0.16		 0.81
0.84		 9 (0.038)
5 (0.025)		 72 (0.308)
54 (0.274)		 153 (0.654)
138 (0.701)
 Caucasian
rs7519259 USA SZ
CTR		 0.48
0.47		 0.52
0.53		 148 (0.230)
91 (0.224)		 321 (0.498)
203 (0.499)		 175 (0.272)
113 (0.278)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele T-Allele A/A
(frequency)		 A/T
(frequency)		 T/T
(frequency)
 African Descent
rs556303 USA SZ
CTR		 0.06
0.07		 0.94
0.93		 1 (0.004)
1 (0.005)		 28 (0.120)
25 (0.127)		 205 (0.876)
171 (0.868)
 Caucasian
rs556303 USA SZ
CTR		 0.37
0.36		 0.63
0.64		 87 (0.135)
54 (0.133)		 300 (0.466)
189 (0.464)		 257 (0.399)
164 (0.403)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 African Descent
rs531244 USA SZ
CTR		 0.19
0.19		 0.81
0.81		 9 (0.038)
7 (0.036)		 73 (0.311)
61 (0.311)		 153 (0.651)
128 (0.653)
 Caucasian
rs531244 USA SZ
CTR		 0.31
0.34		 0.69
0.66		 63 (0.098)
46 (0.113)		 277 (0.430)
181 (0.445)		 304 (0.472)
180 (0.442)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 African Descent
rs4259616 USA SZ
CTR		 0.45
0.48		 0.55
0.52		 47 (0.200)
45 (0.228)		 116 (0.494)
98 (0.497)		 72 (0.306)
54 (0.274)
 Caucasian
rs4259616 USA SZ
CTR		 0.20
0.17		 0.80
0.83		 27 (0.042)
12 (0.029)		 208 (0.323)
118 (0.290)		 409 (0.635)
277 (0.681)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 African Descent
rs2503220 USA SZ
CTR		 0.14
0.16		 0.86
0.84		 5 (0.021)
5 (0.025)		 57 (0.244)
52 (0.263)		 172 (0.735)
141 (0.712)
 Caucasian
rs2503220 USA SZ
CTR		 0.09
0.06		 0.91
0.94		 5 (0.008)
2 (0.005)		 103 (0.160)
49 (0.120)		 536 (0.832)
357 (0.875)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 African Descent
rs2503161 USA SZ
CTR		 0.61
0.64		 0.39
0.36		 89 (0.379)
72 (0.385)		 111 (0.472)
94 (0.503)		 35 (0.149)
21 (0.112)
 Caucasian
rs2503161 USA SZ
CTR		 0.50
0.51		 0.50
0.49		 159 (0.247)
108 (0.265)		 322 (0.500)
203 (0.499)		 163 (0.253)
96 (0.236)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 African Descent
rs2489907 USA SZ
CTR		 0.29
0.35		 0.71
0.65		 20 (0.085)
24 (0.122)		 97 (0.415)
89 (0.452)		 117 (0.500)
84 (0.426)
 Caucasian
rs2489907 USA SZ
CTR		 0.27
0.25		 0.73
0.75		 46 (0.071)
26 (0.064)		 251 (0.390)
155 (0.381)		 347 (0.539)
226 (0.555)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 African Descent
rs1463884 USA SZ
CTR		 0.45
0.41		 0.55
0.59		 48 (0.205)
33 (0.168)		 116 (0.496)
95 (0.482)		 70 (0.299)
69 (0.350)
 Caucasian
rs1463884 USA SZ
CTR		 0.15
0.13		 0.85
0.87		 15 (0.023)
7 (0.017)		 169 (0.262)
95 (0.233)		 460 (0.714)
305 (0.749)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele A-Allele C/C
(frequency)		 C/A
(frequency)		 A/A
(frequency)
 African Descent
rs1354064 USA SZ
CTR		 0.15
0.14		 0.85
0.86		 5 (0.021)
4 (0.020)		 60 (0.256)
48 (0.244)		 169 (0.722)
145 (0.736)
 Caucasian
rs1354064 USA SZ
CTR		 0.09
0.06		 0.91
0.94		 5 (0.008)
1 (0.002)		 101 (0.157)
46 (0.113)		 538 (0.835)
360 (0.885)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 African Descent
rs1338721 USA SZ
CTR		 0.72
0.75		 0.28
0.25		 123 (0.526)
111 (0.563)		 93 (0.397)
74 (0.376)		 18 (0.077)
12 (0.061)
 Caucasian
rs1338721 USA SZ
CTR		 0.48
0.46		 0.52
0.54		 150 (0.233)
85 (0.209)		 322 (0.500)
202 (0.496)		 172 (0.267)
120 (0.295)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 African Descent
rs11208816 USA SZ
CTR		 0.68
0.69		 0.32
0.31		 108 (0.462)
93 (0.472)		 102 (0.436)
85 (0.431)		 24 (0.103)
19 (0.096)
 Caucasian
rs11208816 USA SZ
CTR		 0.48
0.45		 0.52
0.55		 147 (0.228)
83 (0.204)		 321 (0.498)
202 (0.496)		 176 (0.273)
122 (0.300)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
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