SZGene

Polymorphism Details

Study:

Mancama, 2007

Gene:

CHAT (CMS1A; CMS1A2)

View on AlzGene

Protein:

choline acetyltransferase (acetyl CoA:choline O-acetyltransferase)

Chromosome:

10 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 22 May 2007

Total number of polymorphisms investigated by this study: 3

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		A-Allele	G-Allele	A/A (frequency)	A/G (frequency)	G/G (frequency)
Caucasian
rs1880676	Spain	SZ CTR	0.33 0.28	0.67 0.72	11 (0.131) 3 (0.045)	34 (0.405) 31 (0.463)	39 (0.464) 33 (0.493)
rs1880676	Spain (Basque)	SZ CTR	0.30 0.43	0.70 0.57	19 (0.119) 15 (0.121)	57 (0.358) 76 (0.613)	83 (0.522) 33 (0.266)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		T-Allele	C-Allele	T/T (frequency)	T/C (frequency)	C/C (frequency)
Caucasian
rs733722	Spain (Basque)	SZ CTR	0.22 0.22	0.78 0.78	7 (0.047) 6 (0.050)	53 (0.353) 42 (0.347)	90 (0.600) 73 (0.603)
rs733722	Spain	SZ CTR	0.18 0.11	0.83 0.89	1 (0.017) 3 (0.043)	19 (0.317) 10 (0.143)	40 (0.667) 57 (0.814)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		A-Allele	G-Allele	A/A (frequency)	A/G (frequency)	G/G (frequency)
Caucasian
rs3810950	Spain	SZ CTR	0.30 0.29	0.70 0.71	10 (0.152) 5 (0.068)	20 (0.303) 32 (0.438)	36 (0.545) 36 (0.493)
rs3810950	Spain (Basque)	SZ CTR	0.27 0.35	0.73 0.65	16 (0.095) 20 (0.202)	60 (0.357) 30 (0.303)	92 (0.548) 49 (0.495)


SZGene Recent Updates
SZGene Stats Studies: 1727 Genes: 1008 Polymorphisms: 8788 Meta-analyses: 287





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