SZGene

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SZGene - Gene overview of all published SZ-association studies for SLC6A3

Gene:

SLC6A3 (DAT; DAT1)

View on AlzGene View on PDGene

Protein:

solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 (dopamine transporter)

Chromosome:

5 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 22 October 2010

1. Case-Control Studies (by ethnic group)
				SZ Cases				Normal Controls
Study	Population	Source	# Polys	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result	Comment
Caucasian
Alvarez, 2009	Spain	CL	2 (detail)	159 (-)	IV	-	-	290 (62%)	61.7 + 11 (-)	Negative
Bodeau-Pean, 1995	France	CL	1 (detail)	91 (32%)	IIIR	24 + 6.2 (-)	42 + 12 (-)	91 (45%)	48 + 11 (-)	Negative
Cordeiro, 2004	Brazil	CL	1 (detail)	220 (-)	IV	-	-	226 (22%)	-	Negative
Daniels, 1995	UK	CL	1 (detail)	92 (39%)	IIIR	-	56 (26-87)	84 (42%)	52 (18-95)	Negative
Hoogendoorn, 2005	Netherlands	CL	1 (detail)	208 (-)	IV	-	-	288 (-)	-	Negative
Joober, 2000	Canada	CL	1 (detail)	106 (29%)	IV	-	39.5 + 8.3 (-)	89 (-)	-	Negative
Mas, 2009	Spain	CL	14 (detail)	159 (-)	IV	-	-	373 (54%)	51.9 + 19 (-)	Negative
Meda, 2009	USA	CL	1 (detail)	31 (-)	IV	-	-	35 (-)	-	Negative
Pal, 2009	Croatia	CL	8 (detail)	103 (42%)	10	-	436 + 106 (23-74)	131 (-)	503 + 75 (30-74)	Positive
Persico, 1997	Italy	CL	1 (detail)	147 (37%)	IIIR	-	-	84 (-)	-	Trend
Prata, 2009b	Overlaps with Prata, 2009c	CL	1 (detail)	41 (-)	IV	-	-	44 (-)	-	n.a.
Prata, 2009c	UK	CL	1 (detail)	41 (17%)	IV	-	35.2 + 11.4 (-)	44 (50%)	33.4 + 10.1 (-)	Positive
Saiz, 2009	Spain	CL	1 (detail)	288 (40%)	IV	-	363 + 124 (-)	421 (49%)	406 + 113 (-)	Positive
Szekeres, 2004	Hungary	CL	1 (detail)	75 (55%)	IV	-	-	45 (62%)	36.4 + 12.8 (-)	Negative
Talkowski, 2008	USA	CL	17 (detail)	478 (-)	IV	-	-	501 (-)	-	Positive
Talkowski, 2008	Overlaps with Talkowski, 2008	CL	6 (detail)	328 (-)	IV	-	501 (-)	-	-	n.a.
Asian
Fujiwara, 1997	Japan	CL	1 (detail)	115 (-)	M	-	-	26 (-)	-	Negative
Huang, 2009	China	CL	6 (detail)	352 (38%)	IV	27.7 + 11.2 (-)	36.4 + 12.3 (-)	311 (35%)	38 + 10.7 (-)	Positive
Inada, 1996	Japan	CL	1 (detail)	118 (54%)	IIIR	-	59 (22-86)	117 (53%)	46 (20-80)	Negative
Jeong, 2004	Korea	CL	4 (detail)	252 (40%)	IV	-	33.2 + 8.2 (-)	271 (41%)	22.4 + 6.6 (-)	Negative
Li, 1994	China	CL	1 (detail)	105 (33%)	U	-	27.5 + 7.4 (15-51)	98 (36%)	25 + 6.9 (19-50)	Negative
Liu, 2004	Taiwan	CL	1 (detail)	79 (6%)	IV	23.5 + 8.4 (-)	29.1 + 6.2 (-)	72 (8%)	29.6 + 6.8 (-)	Negative
Other/Mixed
Galehdari, 2009	Iran	CL	1 (detail)	200 (42%)	IV	-	43.3 + 11.3 (-)	200 (-)	39.4 + 11.1 (-)	Negative
Khodayari, 2004	Iran	CL	1 (detail)	100 (0%)	IV	-	40.9 + 8 (-)	100 (0%)	45 + 5.4 (-)	Positive
Martinez, 2001	USA	CL	1 (detail)	28 (-)	IV	-	-	31 (-)	-	Negative
Semwal, 2002	India	CL	1 (detail)	536 (44%)	IV	-	22.8 + 7 (-)	936 (47%)	32.9 + 12.7 (-)	Negative
Wonodi, 2008	USA	CL	1 (detail)	190 (-)	IV	-	-	160 (-)	-	Negative

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

2. Family-Based Studies (by ethnic group)
				Affecteds				Unaffecteds
Study	Population	# Polys	# Families	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result	Comment
Caucasian
Cordeiro, 2004	Brazil	1 (detail)	49	49 (-)	IV	-	-	98 (50%)	-	Negative
Georgieva, 2002	Bulgaria	1 (detail)	178	178 (51%)	IV	23.7 + 7.1 (-)	-	356 (50%)	59.6 + 9.1 (-)	Negative
Stober, 2006	Germany	4 (detail)	82	82 (32%)	U	23 + 6.2 (-)	29.8 + 7.3 (-)	164 (50%)	-	Positive
Talkowski, 2008	Bulgaria	16 (detail)	659	659 (50%)	IV	-	-	1318 (50%)	-	Positive
Talkowski, 2008	USA	6 (detail)	150	150 (50%)	IV	-	-	300 (50%)	-	Positive
Other/Mixed
Fanous, 2004	USA	1 (detail)		197 (-)	IIIR	-	-	177 (-)	-	Negative
Maier, 1996	Germany, Israel	2 (detail)	108	-	U	-	-	-	-	Negative
Semwal, 2001	India	1 (detail)	178	179 (42%)	IV	22.1 + 6.3 (-)	-	-	-	Negative

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine SZ diagnosis -> "IIIR"(DSM-IIIR), "IV" (DSM-IV), "9" (ICD-9), "10" (ICD-10), "M" (Mixed), "RDC" (Research Diagnostic Criteria), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.


SZGene Recent Updates
SZGene Stats Studies: 1727 Genes: 1008 Polymorphisms: 8788 Meta-analyses: 287





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