SZGene

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SZGene - Gene overview of all published SZ-association studies for DTNBP1

Gene:

DTNBP1 (SDY; DBND; HPS7; My031; FLJ30031; MGC20210)

Protein:

dystrobrevin binding protein 1 (dysbindin)

Chromosome:

6 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 21 October 2010

1. Case-Control Studies (by ethnic group)
				SZ Cases				Normal Controls
Study	Population	Source	# Polys	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result	Comment
Caucasian
Bakker, 2006	Netherlands	CL	4 (detail)	308 (-)	IV	-	-	580 (-)	-	Negative
Betcheva, 2009	Bulgaria (I)	CL	13 (detail)	185 (-)	IV	-	-	184 (-)	-	Trend
Betcheva, 2009	Bulgaria (II)	CL	1 (detail)	70 (-)	IV	-	-	372 (-)	-	Negative
Datta, 2007	UK	CL	8 (detail)	450 (-)	RDC	-	-	450 (-)	-	Negative
Dutt, 2009	UK, Ireland	CL	2 (detail)	83 (-)	IV	-	-	57 (-)	-	Negative
Dwyer, 2009	UK	CL	7 (detail)	669 (32%)	IV	-	-	710 (33%)	-	Negative
Fallgatter, 2010	Germany	CL	7 (detail)	44 (50%)	IV	-	36.3 + 9.6 (-)	48 (54%)	26.5 + 7.2 (19-63)	n.a.
Funke, 2004	USA (I)	CL	6 (detail)	196 (-)	IV	-	-	467 (52%)	39.3 (-)	Positive
Holliday, 2006	Australia	CL	15 (detail)	194 (-)	M	-	-	180 (-)	-	Negative
Jonsson, 2009	Denmark, Norway, Sweden	CL	11 (detail)	837 (42%)	M	26.5 (-)	45.7 (-)	1473 (42%)	44.1 (-)	Negative
Li, 2005	UK (Scotland)	CL	11 (detail)	580 (28%)	M	-	-	620 (43%)	-	Negative
Morris, 2003	Ireland	CL	8 (detail)	219 (-)	IIIR	-	-	231 (-)	-	Negative
Morris, 2007	Overlaps with Morris, 2003	CL	2 (detail)	373 (-)	IV	-	-	812 (-)	-	n.a.
Morris, 2007	Overlaps with Williams, 2004	CL	1 (detail)	373 (-)	IV	-	-	812 (-)	-	n.a.
Pedrosa, 2006	USA (II)	CL	1 (detail)	172 (-)	M	-	-	165 (-)	-	Negative
Peters, 2008	Australia	CL	37 (detail)	336 (20%)	M	-	-	172 (41%)	-	Negative
Rethelyi, 2009	Hungary	CL	4 (detail)	280 (54%)	IV	28.6 (-)	37.6 (-)	230 (57%)	39.9 (-)	Positive
Riley, 2009	Ireland, UK	CL	9 (detail)	1021 (32%)	IIIR	-	-	626 (45%)	-	Positive
Sanders, 2008	USA, Australia	CL	38 (detail)	1870 (31%)	IV	-	-	2002 (53%)	-	Negative
Strohmaier, 2010	Germany	CL	35 (detail)	634 (45%)	IV	-	38.5 + 11.7 (-)	776 (43%)	45.5 + 13.5 (-)	Negative
Tosato, 2007	Italy	CO	11 (detail)	80 (49%)	10	-	42 (-)	106 (47%)	38 (-)	Positive
Van Den Bogaert, 2003	Overlaps with Strohmaier, 2010 (Germany)	CL	5 (detail)	418 (52%)	IV	-	-	285 (40%)	-	Negative
Van Den Bogaert, 2003	Poland	CL	5 (detail)	294 (41%)	IV	-	-	113 (63%)	-	Negative
Van Den Bogaert, 2003	Sweden	CL	5 (detail)	142 (38%)	IV	-	-	272 (45%)	-	Positive
Vilella, 2007	Spain	PO	11 (detail)	589 (31%)	IV	-	-	615 (48%)	-	Positive
Voisey, 2010	Australia	CL	12 (detail)	160 (14%)	IV	-	36.2 + 12.1 (-)	250 (41%)	36.8 + 12.8 (-)	Positive
Williams, 2004	Overlaps with Morris, 2003	CL	2 (detail)	219 (101%)	IIIR	25.2 + 12.4 (-)	46 + 8.5 (-)	231 (-)	-	Positive
Williams, 2004	UK, Ireland	CL	20 (detail)	708 (31%)	IV	23.6 + 7.7 (-)	41.8 + 13.5 (-)	711 (33%)	-	Positive
Williams, 2004	Ireland (II)	CL	1 (detail)	219 (-)	IIIR	25.2 + 12.4 (-)	46 + 8.5 (-)	231 (-)	-	Positive
Wood, 2006	USA	CL	15 (detail)	311 (-)	IV	-	-	291 (-)	-	Negative
Zuo, 2009	USA (I)	CL	6 (detail)	235 (-)	IIIR	-	-	298 (-)	-	Positive
African Descent
Funke, 2004	USA (II)	CL	6 (detail)	184 (-)	IV	-	-	74 (59%)	31.9 (-)	Positive
Pedrosa, 2006	USA (I)	CL	1 (detail)	152 (-)	M	-	-	129 (-)	-	Negative
Zuo, 2009	USA (II)	CL	6 (detail)	82 (-)	IIIR	-	-	48 (-)	-	Trend
Asian
Hashimoto, 2009	Japan	CL	1 (detail)	70 (39%)	IV	24.8 (-)	45.1 (-)	165 (67%)	37.3 (-)	n.a.
Hokyo, 2010	Japan	CL	1 (detail)	407 (42%)	IV	-	54.7 (-)	384 (64%)	40.1 (-)	Negative
Joo, 2006	Korea	CL	5 (detail)	194 (35%)	IV	22.7 + 5.7 (-)	35 + 6.2 (-)	351 (50%)	25.9 + 6.4 (-)	Negative
Numakawa, 2004	Japan	CL	6 (detail)	670 (49%)	IV	-	44.2 + 14.6 (-)	588 (51%)	36.2 + 12.4 (-)	Positive
Pae, 2009	Korea	CL	4 (detail)	908 (49%)	M	-	33.7 (-)	601 (49%)	38.9 (-)	Positive
Tochigi, 2006	Japan	CL	12 (detail)	314 (44%)	IV	-	46.3 + 14.9 (-)	314 (44%)	37.6 + 11.3 (-)	Positive
Hispanic
Funke, 2004	USA (III)	CL	6 (detail)	41 (-)	IV	-	-	32 (41%)	32.9 (-)	Negative
Other/Mixed
Pedrosa, 2006	USA (I+II)	CL	3 (detail)	324 (-)	M	-	-	294 (-)	-	Negative
Zinkstok, 2007	Netherlands and Other	CL	7 (detail)	76 (13%)	IV	-	21.5 + 2.9 (-)	31 (26%)	21.5 + 3.1 (-)	Negative

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

2. Family-Based Studies (by ethnic group)
				Affecteds				Unaffecteds
Study	Population	# Polys	# Families	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result	Comment
Caucasian
Hall, 2004	South Africa	5 (detail)	233	-	IV	-	-	-	-	Negative
Hall, 2004	USA	5 (detail)	210	-	IV	-	-	-	-	Negative
Holliday, 2006	Australia	15 (detail)	41	114 (-)	M	-	-	135 (-)	-	Negative
Kirov, 2004	Bulgaria	8 (detail)	488	488 (48%)	IV	-	33.1 + 8.2 (-)	976 (50%)	59.9 + 9.2 (-)	Positive
Straub, 2002	Ireland	12 (detail)	270	-	IIIR	-	-	-	-	Positive
Strohmaier, 2010	Overlaps with Schwab, 2003 (Germany)	35 (detail)	180	-	IV	-	-	-	-	Negative
Turunen, 2007	Finland	17 (detail)	441	865 (39%)	IV	-	-	999 (-)	-	Negative
Van Den Oord, 2003	Ireland	14 (detail)	268	-	IIIR	-	-	-	-	Positive
Wessman, 2009	Re-analysis of Turunen, 2007	15 (detail)	292	-	IV	-	-	-	-	n.a.
Asian
Li, 2005	China	8 (detail)	638	810 (45%)	M	-	-	620 (-)	-	Positive
Liu, 2007	Taiwan	9 (detail)	693	1487 (39%)	IV	22.9 + 6.8 (-)	36 + 9.6 (-)	1300 (52%)	55.7 + 15.4 (-)	Negative
Tang, 2003	China	7 (detail)	233	233 (44%)	IIIR	-	22.8 + 0.5 (-)	466 (50%)	-	Positive
Other/Mixed
De Luca, 2005	Canada	3 (detail)	11	-	IV	-	-	-	-	Trend
Duan, 2007	USA	26 (detail)	136	319 (-)	IIIR	-	-	463 (-)	-	Positive
Fallin, 2005	USA	16 (detail)	263	274 (26%)	IV	19.5 + 4.5 (-)	-	548 (50%)	-	Positive
Holliday, 2006	India	15 (detail)	197	329 (-)	M	-	-	339 (-)	-	Negative
Schwab, 2003	Mixed	6 (detail)	203	281 (-)	IV	-	-	-	-	Positive
Zinkstok, 2007	Overlaps with Zinkstok, 2007	7 (detail)		76 (13%)	IV	-	21.5 + 2.9 (-)	31 (58%)	22.8 + 3.8 (-)	n.a.
Zinkstok, 2007	Netherlands and Other	7 (detail)	52	52 (-)	IV	-	-	-	-	Negative

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine SZ diagnosis -> "IIIR"(DSM-IIIR), "IV" (DSM-IV), "9" (ICD-9), "10" (ICD-10), "M" (Mixed), "RDC" (Research Diagnostic Criteria), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.


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SZGene Stats Studies: 1727 Genes: 1008 Polymorphisms: 8788 Meta-analyses: 287





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