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SZGene - Gene overview of all published SZ-association studies for GFRA1    
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 Gene: GFRA1  (GDNFR; RET1L; RETL1; TRNR1; GDNFRA; GFR-ALPHA-1)  Entrez Gene
 Protein: GDNF family receptor alpha 1  (RET ligand 1; GPI-linked anchor protein; PI-linked cell-surface accessory protein; TGF-beta related neurotrophic factor receptor 1; Glial cell line-derived neurotrophic factor receptor alpha)  ProteinLink
 Chromosome: 10   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 22 October 2010
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      SZ Cases Normal Controls    
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Jungerius, 2007
Netherlands CL  14  (detail)  310
(-)
IV--880
(-)
-Negative
O'Donovan, 2008
Overlaps with
O'Donovan, 2008a
CL  2  (detail)  642
(32%)
IV23.8 + 7.9
(-)
43.9 + 14.4
(-)
2937
(51%)
-n.a.
O'Donovan, 2008a
UK CL  2  (detail)  642
(32%)
IV23.8 + 7.9
(-)
43.9 + 14.4
(-)
2937
(51%)
-Positive
O'Donovan, 2008a
Ireland CL  1  (detail)  295
(32%)
IV23.8 + 8.7
(-)
45.1 + 9.6
(-)
983
(70%)
36 + 12.4
(-)
Negative
O'Donovan, 2008a
Bulgaria CL  1  (detail)  611
(47%)
IV24.2 + 6.9
(-)
35.3 + 9.6
(-)
661
(51%)
49 + 15.5
(-)
Negative
O'Donovan, 2008a
Germany (Munich) CL  1  (detail)  758
(36%)
IV24.6 + 8.2
(-)
38 + 11.4
(-)
1897
(52%)
49 + 16
(-)
Negative
Souza, 2010
USA, Canada CL  25  (detail)  219
(-)
IV--219
(33%)
36 + 8
(-)
Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds    
Study Population # Polys # Families # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Fallin, 2005
USA  12  (detail)  263274
(26%)
IV19.5 + 4.5
(-)
-548
(50%)
-Negative
Souza, 2010
Canada  25  (detail)  85-IV----Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine SZ diagnosis ->  "IIIR"(DSM-IIIR), "IV" (DSM-IV), "9" (ICD-9), "10" (ICD-10), "M" (Mixed), "RDC" (Research Diagnostic Criteria), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
SZGene Recent Updates
SZGene Stats
Studies: 1727
Genes: 1008
Polymorphisms: 8788
Meta-analyses: 287
ALSGene
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SZGene
An up-to-date collection of all published genetic association studies.
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