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SZGene - Gene overview of all published SZ-association studies for DISC1    
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 Gene: DISC1  (SCZD9)  Entrez Gene
 Protein: disrupted in schizophrenia 1   ProteinLink
 Chromosome: 1   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 21 October 2010
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      SZ Cases Normal Controls    
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Betcheva, 2009
Bulgaria (I) CL  15  (detail)  185
(-)
IV--184
(-)
-Trend
Betcheva, 2009
Bulgaria (II) CL  1  (detail)  70
(-)
IV--372
(-)
-Negative
Devon, 2001
UK (Scotland) CL  4  (detail)  328
(-)
M--726
(-)
-Negative
Hennah, 2009
UK (London) CL  64  (detail)  348
(31%)
IV--351
(55%)
-Positive
Hennah, 2009
Overlaps with
Thompson, 2005 (Edinburgh)
CL  64  (detail)  328
(29%)
IV--315
(45%)
-Positive
Hennah, 2009
Overlaps with
Zhang, 2006 (Aberdeen)
CL  64  (detail)  256
(20%)
IV--255
(42%)
-Positive
Hennah, 2009
Finland CL,PO  64  (detail)  343
(35%)
IV--342
(59%)
-Positive
Hodgkinson, 2004
USA CL  39  (detail)  196
(28%)
IV-39.1
(-)
217
(59%)
46.3
(-)
Positive
Mata, 2009
Spain CL  3  (detail)  91
(38%)
IV27.9 + 7.9
(-)
-21
(38%)
-Positive
Meda, 2009
USA CL  5  (detail)  31
(-)
IV--35
(-)
-Negative
Mouaffak, 2010
France CL  3  (detail)  222
(31%)
IV-30.7 + 9.3
(-)
151
(58%)
25.5 + 6.6
(-)
Positive
Nicodemus, 2006
Germany CL  5  (detail)  501
(35%)
IV--627
(52%)
-Positive
Nicodemus, 2010
USA CL  12  (detail)  296
(22%)
IV--365
(52%)
-Trend
Rastogi, 2009
Canada CL  9  (detail)  210
(-)
IV--210
(-)
-Positive
Saetre, 2008
Denmark CL  15  (detail)  420
(43%)
M27.2 + 8.9
(-)
43.9 + 12.3
(-)
1004
(42%)
43.2 + 11.8
(-)
Positive
Saetre, 2008
Norway CL  15  (detail)  162
(46%)
M27.6 + 8.7
(-)
37.2 + 10.7
(-)
177
(55%)
38.7 + 10.3
(-)
Positive
Saetre, 2008
Sweden CL  15  (detail)  255
(37%)
M24.6 + 6.9
(-)
54.1 + 15.2
(-)
292
(38%)
50.3 + 10.1
(-)
Positive
Sanders, 2008
USA, Australia CL  110  (detail)  1870
(31%)
IV--2002
(53%)
-Negative
Schumacher, 2009
Germany CL  109  (detail)  782
(45%)
IV--839
(43%)
-Positive
Song, 2007
USA CL  7  (detail)  288
(70%)
IV--288
(-)
-Positive
Szeszko, 2008
USA CL  1  (detail)  19
(26%)
IV22.7 + 5.1
(-)
26.3 + 5.9
(-)
25
(56%)
27.1 + 6.8
(-)
Positive
Thomson, 2005
UK (Scotland) CL  26  (detail)  394
(28%)
IV--478
(48%)
-Positive
Wilson-Annan, 1997
UK CL  1  (detail)  105
(-)
IV--143
(-)
-Negative
Wood, 2006
USA CL  71  (detail)  311
(-)
IV--291
(-)
-Positive
Zhang, 2006
UK (Scotland) CL  7  (detail)  677
(-)
IV-37
(17-66)
648
(-)
36
(18-58)
Positive
 Asian
Chen, 2006
China CL  3  (detail)  560
(47%)
IV-37.3 + 13.6
(-)
576
(48%)
33.2 + 10.4
(-)
Trend
Hashimoto, 2006
Japan CL  13  (detail)  658
(48%)
IV24.2 + 8.6
(-)
43.6 + 14.6
(-)
717
(51%)
41.3 + 16.9
(-)
Positive
Kim, 2007
Korea CL  3  (detail)  303
(38%)
IV-43.1 + 10.8
(-)
300
(51%)
36.6 + 6
(-)
Negative
Kockelkorn, 2004
Japan (I) CL  6  (detail)  198
(47%)
IV-53.4 + 11.5
(-)
198
(53%)
55.2 + 17.2
(-)
Positive
Kockelkorn, 2004
Japan (II) CL  2  (detail)  532
(50%)
IV-45.6 + 11
(-)
519
(50%)
45.1 + 11.8
(-)
Negative
Qu, 2007
China CL  4  (detail)  313
(47%)
10-32.2 + 6.4
(-)
317
(45%)
33.5 + 8.7
(-)
Positive
Zhang, 2005
Japan CL  12  (detail)  338
(46%)
IV-46.3 + 14.7
(-)
338
(46%)
40.3 + 11.3
(-)
Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds    
Study Population # Polys # Families # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Callicott, 2005
USA (NIMHGI I)  12  (detail)  67-U----Positive
Callicott, 2005
USA  12  (detail)  219252
(22%)
IV-36.1
(-)
311
(59%)
37.4 + 9.4
(-)
Positive
Cannon, 2005
Finland  5  (detail)  11865
(51%)
M-47.6 + 5.1
(-)
171
(51%)
-Positive
Ekelund, 2004
Finland  4  (detail)  7079
(-)
IV----Positive
Fallin, 2005
USA  19  (detail)  263274
(26%)
IV19.5 + 4.5
(-)
-548
(50%)
-Negative
Hennah, 2003
Finland  21  (detail)   607
(-)
IV----Positive
Lepagnol-Bestel, 2010
France  4  (detail)  114-IV----Positive
Lepagnol-Bestel, 2010
Algeria  4  (detail)  100-IV----Positive
Nicodemus, 2006
Overlaps with
Callicott, 2005
 5  (detail)  296-IV--627
(-)
-n.a.
Rastogi, 2009
Canada  9  (detail)  117-IV----Positive
Wessman, 2009
Re-analysis of Hennah, 2003  21  (detail)  292-IV----n.a.
 African Descent
Callicott, 2005
USA (NIMHGI II)  12  (detail)  51-U----Positive
 Asian
Liu, 2006
Taiwan  26  (detail)  102-IV----Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine SZ diagnosis ->  "IIIR"(DSM-IIIR), "IV" (DSM-IV), "9" (ICD-9), "10" (ICD-10), "M" (Mixed), "RDC" (Research Diagnostic Criteria), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
SZGene Recent Updates
SZGene Stats
Studies: 1727
Genes: 1008
Polymorphisms: 8788
Meta-analyses: 287
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