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Printable version
SZGene - Gene overview of all published SZ-association studies for DISC1
Gene:
DISC1
(SCZD9)
Protein:
disrupted in schizophrenia 1
Chromosome:
1
(View:
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
X
Y
MT
)
Status:
Updated 21 October 2010
1. Case-Control Studies (by ethnic group)
SZ Cases
Normal Controls
Study
Population
Source
# Polys
# Subjects
(% women)
DX
Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
Comment
Caucasian
Betcheva, 2009
Bulgaria (I)
CL
15
(detail)
185
(-)
IV
-
-
184
(-)
-
Trend
Betcheva, 2009
Bulgaria (II)
CL
1
(detail)
70
(-)
IV
-
-
372
(-)
-
Negative
Devon, 2001
UK (Scotland)
CL
4
(detail)
328
(-)
M
-
-
726
(-)
-
Negative
Hennah, 2009
UK (London)
CL
64
(detail)
348
(31%)
IV
-
-
351
(55%)
-
Positive
Hennah, 2009
Overlaps with
Thompson, 2005 (Edinburgh)
CL
64
(detail)
328
(29%)
IV
-
-
315
(45%)
-
Positive
Hennah, 2009
Overlaps with
Zhang, 2006 (Aberdeen)
CL
64
(detail)
256
(20%)
IV
-
-
255
(42%)
-
Positive
Hennah, 2009
Finland
CL,PO
64
(detail)
343
(35%)
IV
-
-
342
(59%)
-
Positive
Hodgkinson, 2004
USA
CL
39
(detail)
196
(28%)
IV
-
39.1
(-)
217
(59%)
46.3
(-)
Positive
Mata, 2009
Spain
CL
3
(detail)
91
(38%)
IV
27.9 + 7.9
(-)
-
21
(38%)
-
Positive
Meda, 2009
USA
CL
5
(detail)
31
(-)
IV
-
-
35
(-)
-
Negative
Mouaffak, 2010
France
CL
3
(detail)
222
(31%)
IV
-
30.7 + 9.3
(-)
151
(58%)
25.5 + 6.6
(-)
Positive
Nicodemus, 2006
Germany
CL
5
(detail)
501
(35%)
IV
-
-
627
(52%)
-
Positive
Nicodemus, 2010
USA
CL
12
(detail)
296
(22%)
IV
-
-
365
(52%)
-
Trend
Rastogi, 2009
Canada
CL
9
(detail)
210
(-)
IV
-
-
210
(-)
-
Positive
Saetre, 2008
Denmark
CL
15
(detail)
420
(43%)
M
27.2 + 8.9
(-)
43.9 + 12.3
(-)
1004
(42%)
43.2 + 11.8
(-)
Positive
Saetre, 2008
Norway
CL
15
(detail)
162
(46%)
M
27.6 + 8.7
(-)
37.2 + 10.7
(-)
177
(55%)
38.7 + 10.3
(-)
Positive
Saetre, 2008
Sweden
CL
15
(detail)
255
(37%)
M
24.6 + 6.9
(-)
54.1 + 15.2
(-)
292
(38%)
50.3 + 10.1
(-)
Positive
Sanders, 2008
USA, Australia
CL
110
(detail)
1870
(31%)
IV
-
-
2002
(53%)
-
Negative
Schumacher, 2009
Germany
CL
109
(detail)
782
(45%)
IV
-
-
839
(43%)
-
Positive
Song, 2007
USA
CL
7
(detail)
288
(70%)
IV
-
-
288
(-)
-
Positive
Szeszko, 2008
USA
CL
1
(detail)
19
(26%)
IV
22.7 + 5.1
(-)
26.3 + 5.9
(-)
25
(56%)
27.1 + 6.8
(-)
Positive
Thomson, 2005
UK (Scotland)
CL
26
(detail)
394
(28%)
IV
-
-
478
(48%)
-
Positive
Wilson-Annan, 1997
UK
CL
1
(detail)
105
(-)
IV
-
-
143
(-)
-
Negative
Wood, 2006
USA
CL
71
(detail)
311
(-)
IV
-
-
291
(-)
-
Positive
Zhang, 2006
UK (Scotland)
CL
7
(detail)
677
(-)
IV
-
37
(17-66)
648
(-)
36
(18-58)
Positive
Asian
Chen, 2006
China
CL
3
(detail)
560
(47%)
IV
-
37.3 + 13.6
(-)
576
(48%)
33.2 + 10.4
(-)
Trend
Hashimoto, 2006
Japan
CL
13
(detail)
658
(48%)
IV
24.2 + 8.6
(-)
43.6 + 14.6
(-)
717
(51%)
41.3 + 16.9
(-)
Positive
Kim, 2007
Korea
CL
3
(detail)
303
(38%)
IV
-
43.1 + 10.8
(-)
300
(51%)
36.6 + 6
(-)
Negative
Kockelkorn, 2004
Japan (I)
CL
6
(detail)
198
(47%)
IV
-
53.4 + 11.5
(-)
198
(53%)
55.2 + 17.2
(-)
Positive
Kockelkorn, 2004
Japan (II)
CL
2
(detail)
532
(50%)
IV
-
45.6 + 11
(-)
519
(50%)
45.1 + 11.8
(-)
Negative
Qu, 2007
China
CL
4
(detail)
313
(47%)
10
-
32.2 + 6.4
(-)
317
(45%)
33.5 + 8.7
(-)
Positive
Zhang, 2005
Japan
CL
12
(detail)
338
(46%)
IV
-
46.3 + 14.7
(-)
338
(46%)
40.3 + 11.3
(-)
Negative
Contact us
if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
Affecteds
Unaffecteds
Study
Population
# Polys
# Families
# Subjects
(% women)
DX
Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
Comment
Caucasian
Callicott, 2005
USA (NIMHGI I)
12
(detail)
67
-
U
-
-
-
-
Positive
Callicott, 2005
USA
12
(detail)
219
252
(22%)
IV
-
36.1
(-)
311
(59%)
37.4 + 9.4
(-)
Positive
Cannon, 2005
Finland
5
(detail)
118
65
(51%)
M
-
47.6 + 5.1
(-)
171
(51%)
-
Positive
Ekelund, 2004
Finland
4
(detail)
70
79
(-)
IV
-
-
-
-
Positive
Fallin, 2005
USA
19
(detail)
263
274
(26%)
IV
19.5 + 4.5
(-)
-
548
(50%)
-
Negative
Hennah, 2003
Finland
21
(detail)
607
(-)
IV
-
-
-
-
Positive
Lepagnol-Bestel, 2010
France
4
(detail)
114
-
IV
-
-
-
-
Positive
Lepagnol-Bestel, 2010
Algeria
4
(detail)
100
-
IV
-
-
-
-
Positive
Nicodemus, 2006
Overlaps with
Callicott, 2005
5
(detail)
296
-
IV
-
-
627
(-)
-
n.a.
Rastogi, 2009
Canada
9
(detail)
117
-
IV
-
-
-
-
Positive
Wessman, 2009
Re-analysis of Hennah, 2003
21
(detail)
292
-
IV
-
-
-
-
n.a.
African Descent
Callicott, 2005
USA (NIMHGI II)
12
(detail)
51
-
U
-
-
-
-
Positive
Asian
Liu, 2006
Taiwan
26
(detail)
102
-
IV
-
-
-
-
Positive
Contact us
if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:
Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:
Number of polymorphisms tested per gene and per sample.
Onset Age and Age:
Mean or median age at onset or examination, respectively.
DX:
Criteria used to determine SZ diagnosis -> "IIIR"(DSM-IIIR), "IV" (DSM-IV), "9" (ICD-9), "10" (ICD-10), "M" (Mixed), "RDC" (Research Diagnostic Criteria), "U" (Unknown).
Result:
Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-)
: Either no data provided or in case of overlap, data included in original study.
SZGene Recent Updates
SZGene Stats
Studies: 1727
Genes: 1008
Polymorphisms: 8788
Meta-analyses: 287
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