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SZGene - Gene overview of all published SZ-association studies for DRD1    
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 Gene: DRD1  (DADR; DRD1A)  Entrez Gene    View on PDGene
 Protein: dopamine receptor D1   ProteinLink
 Chromosome: 5   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 21 October 2010
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      SZ Cases Normal Controls    
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Campion, 1994
France PO  1  (detail)  80
(-)
IIIR--80
(-)
-Negative
Cichon, 1994
Germany CL  4  (detail)  36
(36%)
IIIR--45
(-)
-Negative
Cichon, 1996
Germany CL  3  (detail)  36
(-)
IIIR--45
(-)
28.2 + 5.2
(23-52)
Negative
Dmitrzak-Weglarz, 2006
Poland CL  1  (detail)  407
(46%)
M-31 + 11.5
(-)
399
(62%)
40.6 + 11.8
(-)
Negative
Dollfus, 1996
France PO  1  (detail)  62
(-)
M--161
(-)
-Negative
Hoenicka, 2010
Spain CL  5  (detail)  337
(33%)
IV--364
(53%)
-Positive
Hoogendoorn, 2005
Netherlands CL  2  (detail)  208
(-)
IV--288
(-)
-Negative
Liu, 1995
USA CL  1  (detail)  86
(-)
IIIR--338
(-)
-Negative
Nothen, 1993
Germany CL  1  (detail)  60
(33%)
IIIR25.2 + 8
(14-46)
34.8 + 11
(-)
60
(47%)
28.2 + 5.2
(-)
Negative
Talkowski, 2008
USA CL  3  (detail)  328
(-)
IV--501
(-)
-Negative
 Asian
Iwata, 2003
Japan CL  1  (detail)  51
(57%)
IV13.5 + 1.7
(9-16)
20 + 7
(-)
148
(56%)
21 + 7
(-)
Negative
Kojima, 1999
Japan CL  1  (detail)  148
(56%)
IV27.5 + 8.1
(-)
54.3 + 11.5
(16-74)
148
(51%)
55.4 + 6.8
(45-74)
Negative
Zhang, 2010
China CL  5  (detail)  373
(35%)
IV15.2 + 2.6
(6-18)
33 + 18
(-)
379
(44%)
32 + 9
(-)
Negative
 Other/Mixed
Srivastava, 2010
India CL  5  (detail)  215
(48%)
IV21.4 + 6.1
(-)
29.3 + 8.9
(-)
215
(40%)
34.6 + 12.4
(-)
Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds    
Study Population # Polys # Families # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Fallin, 2005
USA  2  (detail)  263274
(26%)
IV19.5 + 4.5
(-)
-548
(50%)
-Negative
Talkowski, 2008
USA  3  (detail)  150150
(50%)
IV--300
(50%)
-Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine SZ diagnosis ->  "IIIR"(DSM-IIIR), "IV" (DSM-IV), "9" (ICD-9), "10" (ICD-10), "M" (Mixed), "RDC" (Research Diagnostic Criteria), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
SZGene Recent Updates
SZGene Stats
Studies: 1727
Genes: 1008
Polymorphisms: 8788
Meta-analyses: 287
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An up-to-date collection of all published genetic association studies.
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