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SZGene - Gene overview of all published SZ-association studies for GABRB2    
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 Gene: GABRB2   Entrez Gene
 Protein: gamma-aminobutyric acid (GABA) A receptor, beta 2   ProteinLink
 Chromosome: 5   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 22 October 2010
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      SZ Cases Normal Controls    
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Betcheva, 2009
Bulgaria (I) CL  5  (detail)  185
(-)
IV--184
(-)
-Positive
Betcheva, 2009
Bulgaria (II) CL  1  (detail)  70
(-)
IV--372
(-)
-Negative
Jamra, 2007
Germany CL  5  (detail)  367
(-)
IV--360
(-)
-Negative
Lo, 2006
Germany CL  15  (detail)  301
(20%)
IV-28.3 + 10.1
(-)
190
(40%)
29.3 + 9
(-)
Positive
Lo, 2007
Overlaps with
Lo, 2006 Germany
CL  4  (detail)  119
(0%)
IV--114
(0%)
-n.a.
Lo, 2007
USA CL  4  (detail)  107
(0%)
IV--136
(0%)
-Positive
Petryshen, 2005
Portugal CL  56  (detail)  321
(41%)
IV--242
(61%)
-Positive
Yu, 2006
Germany CL  6  (detail)  155
(-)
IV-27.1 + 9.2
(-)
190
(-)
29.3 + 9
(-)
Positive
 Asian
Ikeda, 2005
Japan CL  8  (detail)  288
(49%)
IV-39.6 + 14
(-)
288
(48%)
33.6 + 14
(-)
Negative
Lo, 2004
China CL  10  (detail)  137
(-)
IV26.7
(-)
47.9
(-)
171
(-)
33.5
(-)
Positive
Lo, 2006
Japan CL  11  (detail)  304
(31%)
IV-54.8 + 13.3
(-)
207
(51%)
48.8 + 23.9
(-)
Positive
Lo, 2007
Overlaps with
Lo, 2004
CL  4  (detail)  -IV----n.a.
Lo, 2007
Overlaps with
Lo, 2006 Japan
CL  4  (detail)  210
(0%)
IV--102
(0%)
-n.a.
Zhao, 2006
China CL  16  (detail)  31
(26%)
IV21.4 + 5.6
(-)
43.3 + 8.6
(-)
31
(23%)
43.5 + 7.4
(-)
Positive
Zhao, 2007
China CL  6  (detail)  292
(48%)
IIIR-41 + 9.1
(-)
286
(50%)
33.3 + 8.4
(-)
Positive
Zhao, 2009
China CL  1  (detail)  31
(26%)
M-43.3 + 8.6
(-)
31
(23%)
43.5 + 7.4
(-)
n.a.
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds    
Study Population # Polys # Families # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Petryshen, 2005
Portugal  56  (detail)  111111
(29%)
IV--222
(50%)
-Positive
Petryshen, 2005
Germany  56  (detail)  238238
(38%)
IV--476
(50%)
-Positive
Pun, 2010
USA  29  (detail)  150-IV----Positive
 African Descent
Lo, 2007
Nigeria  4  (detail)  3030
(23%)
IV--58
(48%)
-Positive
 Asian
Liu, 2005
China  6  (detail)  352352
(47%)
IIIR-23.8 + 6.6
(-)
704
(50%)
-Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine SZ diagnosis ->  "IIIR"(DSM-IIIR), "IV" (DSM-IV), "9" (ICD-9), "10" (ICD-10), "M" (Mixed), "RDC" (Research Diagnostic Criteria), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
SZGene Recent Updates
SZGene Stats
Studies: 1727
Genes: 1008
Polymorphisms: 8788
Meta-analyses: 287
ALSGene
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MSGene
PDGene
SZGene
An up-to-date collection of all published genetic association studies.
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