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SZGene - Gene overview of all published SZ-association studies for TNF    
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 Gene: TNF  (DIF; TNFA; TNFSF2; TNF-alpha)  Entrez Gene    View on ALSGene   View on AlzGene   View on MSGene   View on PDGene
 Protein: tumor necrosis factor alpha  (cachectin; APC1 protein)  ProteinLink
 Chromosome: 6   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 22 October 2010
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      SZ Cases Normal Controls    
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Betcheva, 2009
Bulgaria CL  1  (detail)  185
(-)
IV--184
(-)
-Negative
Boin, 2001
Italy CL  1  (detail)  84
(33%)
IV25.6 + 5.9
(-)
43.4 + 9.5
(-)
138
(43%)
-Positive
Handoko, 2003
Australia CL  3  (detail)  65
(-)
IIIR--151
(-)
-Negative
Hanninen, 2005
Finland CL  1  (detail)  149
(37%)
IV23.6 + 6.3
(-)
38.7 + 12.2
(18-76)
393
(46%)
44.5 + 11.1
(19-65)
Trend
Kampman, 2005
Finland CL  1  (detail)  94
(51%)
IV29.7 + 9.9
(-)
45.9 + 10.9
(-)
98
(52%)
45.9 + 11.2
(-)
Negative
Riedel, 2002
Germany CL  1  (detail)  157
(41%)
IV27.6 + 9.5
(-)
33.3 + 11.7
(17-65)
186
(53%)
46.9 + 13.6
(22-76)
Negative
Sacchetti, 2007
Overlaps with
Boin, 2001
CL  1  (detail)  323
(40%)
IV24.4 + 7.8
(-)
41.1 + 12.1
(-)
346
(45%)
48.2 + 15.6
(-)
Trend
Shirts, 2006
USA CL  8  (detail)  125
(35%)
IV-38.7 + 9.7
(-)
276
(49%)
-Negative
Zai, 2006
Canada CL  1  (detail)  149
(-)
M19.4 + 5.2
(-)
37.2 + 9.6
(-)
149
(-)
-Negative
 Asian
Duan, 2004
China CL  5  (detail)  314
(52%)
IV28.2 + 8
(-)
48.5 + 13.3
(-)
340
(-)
34.3 + 10.4
(-)
Negative
Handoko, 2003
Fiji (I) CL  3  (detail)  69
(-)
IIIR--47
(100%)
-Negative
Handoko, 2003
Fiji (II) CL  3  (detail)  98
(-)
IIIR--47
(100%)
-Negative
Hashimoto, 2004
Japan CL  1  (detail)  297
(45%)
IV-43.7 + 14.1
(-)
458
(49%)
36.4 + 12.6
(-)
Negative
Pae, 2003
Korea CL  1  (detail)  241
(54%)
IV24 + 5.2
(-)
32.1 + 9.5
(-)
125
(62%)
37.6 + 6.9
(-)
Negative
Pae, 2006
Korea CL  2  (detail)  152
(52%)
IV-36.9 + 11.6
(-)
152
(55%)
32 + 10.7
(-)
Negative
Tan, 2003
Singapore CL  4  (detail)  302
(26%)
IV22.2 + 7.1
(-)
53.2 + 16.2
(-)
152
(59%)
44.5 + 15.6
(-)
Positive
Tsai, 2003
Taiwan CL  1  (detail)  205
(51%)
IV-37.2 + 8.4
(-)
192
(57%)
37.5 + 8.4
(-)
Negative
Watanabe, 2007
Japan CL  4  (detail)  265
(46%)
IV23.7 + 7.9
(-)
45.2 + 14.9
(-)
424
(49%)
38.3 + 10.5
(-)
Negative
Zhang, 2005
China CL  1  (detail)  111
(38%)
IV--146
(36%)
-Negative
 Other/Mixed
Meira-Lima, 2003
Brazil CL  1  (detail)  186
(47%)
IIIR20.6 + 6
(-)
36 + 8
(-)
657
(57%)
40 + 11
(-)
Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds    
Study Population # Polys # Families # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Handoko, 2003
Australia  3  (detail)  8181
(-)
IIIR--192
(42%)
-Negative
Morar, 2006
Australia  3  (detail)  204-IIIR----Positive
Saviouk, 2005
Canada  2  (detail)  2285
(-)
IIIR----Positive
Zai, 2006
Canada  1  (detail)  9595
(-)
M19.4 + 5.2
(-)
37.2 + 9.6
(-)
--Negative
 Asian
Handoko, 2003
Overlaps with
Handoko, 2003 Fiji (I)
 3  (detail)  6969
(-)
IIIR--89
(-)
-Negative
Handoko, 2003
Overlaps with
Handoko, 2003 Fiji (II)
 3  (detail)  9898
(-)
IIIR--126
(-)
-Negative
Watanabe, 2007
Japan  4  (detail)  8383
(47%)
IV21.1 + 5.1
(-)
29.9 + 9.5
(-)
166
(50%)
-Negative
 Other/Mixed
Handoko, 2003
India  3  (detail)  6666
(-)
IIIR--132
(50%)
-Negative
Schwab, 2003
Germany, Hungary, Israel  1  (detail)  207300
(-)
IIIR--198
(-)
-Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine SZ diagnosis ->  "IIIR"(DSM-IIIR), "IV" (DSM-IV), "9" (ICD-9), "10" (ICD-10), "M" (Mixed), "RDC" (Research Diagnostic Criteria), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
SZGene Recent Updates
SZGene Stats
Studies: 1727
Genes: 1008
Polymorphisms: 8788
Meta-analyses: 287
ALSGene
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An up-to-date collection of all published genetic association studies.
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