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SZGene - Gene overview of all published SZ-association studies for ZNF804A    
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 Gene: ZNF804A  (C2orf10)  Entrez Gene
 Protein: zinc finger protein 804A   ProteinLink
 Chromosome: 2   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 15 November 2010
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      SZ Cases Normal Controls    
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Dwyer, 2010
Overlaps with
O'Donovan, 2008
CL  10  (detail)  517
(-)
IV--501
(-)
-Negative
O'Donovan, 2008
Israel CL  1  (detail)  741
(36%)
IV24.3 + 8.2
(-)
45.7 + 13.9
(-)
1517
(22%)
39.9 + 13.7
(-)
Positive
O'Donovan, 2008
UK CL  1  (detail)  642
(32%)
IV23.8 + 7.9
(-)
43.9 + 14.4
(-)
2937
(51%)
-Positive
O'Donovan, 2008
Ireland CL  1  (detail)  295
(32%)
IV23.8 + 8.7
(-)
45.1 + 9.6
(-)
983
(70%)
36 + 12.4
(-)
Positive
O'Donovan, 2008
Bulgaria CL  1  (detail)  611
(47%)
IV24.2 + 6.9
(-)
35.3 + 9.6
(-)
661
(51%)
49 + 15.5
(-)
Positive
O'Donovan, 2008
Germany (Munich) CL  1  (detail)  758
(36%)
IV24.6 + 8.2
(-)
38 + 11.4
(-)
1897
(52%)
49 + 16
(-)
Positive
O'Donovan, 2008
Germany (Bonn) CL  1  (detail)  735
(47%)
IV22.4 + 10.1
(-)
40.1 + 13.3
(-)
1036
(48%)
46.5 + 15.8
(-)
Positive
O'Donovan, 2008
USA CL  1  (detail)  1744
(31%)
IV-42.8 + 11.4
(-)
1938
(53%)
50.6 + 16.7
(-)
Positive
Riley, 2009
Ireland, UK CL  12  (detail)  1021
(32%)
IIIR--626
(45%)
-Positive
Steinberg, 2010
Hungary CL  1  (detail)  280
(-)
IV--230
(-)
-Negative
Steinberg, 2010
Norway CL  1  (detail)  283
(-)
M--468
(-)
-Negative
Steinberg, 2010
Russia CL  1  (detail)  498
(-)
IV--500
(-)
-Positive
Steinberg, 2010
Sweden CL  1  (detail)  257
(-)
M--293
(-)
-Negative
Steinberg, 2010
Finland CL  1  (detail)  200
(-)
IV--200
(-)
-Negative
Steinberg, 2010
Germany (Bonn) CL  1  (detail)  285
(-)
IV--522
(-)
-Negative
Steinberg, 2010
Germany (Munich) CL  1  (detail)  185
(-)
IV--322
(-)
-Negative
Steinberg, 2010
Denmark (Aarhus) CL  1  (detail)  236
(-)
M--500
(-)
-Negative
Steinberg, 2010
Denmark (Copenhagen) CL  1  (detail)  514
(-)
10--1340
(-)
-Positive
Steinberg, 2010
UK (England) CL  1  (detail)  118
(-)
10--98
(-)
-Negative
Steinberg, 2010
Italy CL  1  (detail)  90
(-)
10--93
(-)
-Negative
Steinberg, 2010
Netherlands CL  1  (detail)  715
(-)
IV--3977
(-)
-Negative
Steinberg, 2010
UK (Scotland) CL  1  (detail)  671
(-)
M--671
(-)
-Negative
Steinberg, 2010
Iceland CL  1  (detail)  620
(-)
M--37154
(-)
-Negative
Walters, 2010
Overlaps with
O'Donovan, 2008 (Ireland)
CL  1  (detail)  297
(29%)
IV-41.3
(-)
165
(50%)
37.4
(-)
n.a.
Walters, 2010
Overlaps with
O'Donovan, 2008 (Germany)
CL  1  (detail)  251
(37%)
IV-37.1
(-)
1472
(56%)
44.5
(-)
n.a.
Williams, 2010
Overlaps with
O'Donovan, 2008 (stage1)
CL  13  (detail)  479
(-)
IV--1445
(-)
-Positive
Williams, 2010
Overlaps with
O'Donovan, 2008 (stage2)
CL  9  (detail)  1827
(-)
IV--4969
(-)
-Positive
 Asian
Hashimoto, 2010
Japan CL  1  (detail)  113
(48%)
IV24.1
(-)
38.3 + 12.1
(-)
184
(52%)
36.2 + 11.5
(-)
Positive
O'Donovan, 2008
Japan CL  1  (detail)  748
(46%)
IV-45.3 + 15.4
(-)
831
(44%)
39.6 + 15.4
(-)
Positive
O'Donovan, 2008
China CL  1  (detail)  1034
(45%)
IV25.2 + 11.1
(-)
38.8 + 14.1
(-)
1034
(50%)
30 + 8.7
(-)
Positive
Steinberg, 2010
China CL  1  (detail)  470
(-)
IV--470
(-)
-Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine SZ diagnosis ->  "IIIR"(DSM-IIIR), "IV" (DSM-IV), "9" (ICD-9), "10" (ICD-10), "M" (Mixed), "RDC" (Research Diagnostic Criteria), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
SZGene Recent Updates
SZGene Stats
Studies: 1727
Genes: 1008
Polymorphisms: 8788
Meta-analyses: 287
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