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Polymorphism Details     
Back Search Methods Disclaimer Credits
 Study: Norton, 2006
 Gene: ERBB4  (HER4; p180erbB4)  Entrez Gene
 Protein: v-erb-a erythroblastic leukemia viral oncogene homolog 4  (receptor tyrosine-protein kinase erbB-4; tyrosine kinase-type cell surface receptor HER4; avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4; v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4)  ProteinLink
 Chromosome: 2   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 21 October 2010
Meta-Analysis     Gene Overview
Total number of polymorphisms investigated by this study: 28

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   m-Allele M-Allele m/m
(frequency)
m/M
(frequency)
M/M
(frequency)
 Caucasian
ERBB4_3228A>G Ireland SZ
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
ERBB4_3228A>G UK (Cardiff) SZ
CTR
0.35
0.33
0.65
0.67
45 (0.122)
40 (0.109)
167 (0.454)
163 (0.443)
156 (0.424)
165 (0.448)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   m-Allele M-Allele m/m
(frequency)
m/M
(frequency)
M/M
(frequency)
 Caucasian
ERBB4_IVS10+60C>T UK (Cardiff) SZ
CTR
0.45
0.45
0.55
0.55
75 (0.204)
75 (0.204)
182 (0.495)
182 (0.495)
111 (0.302)
111 (0.302)
ERBB4_IVS10+60C>T Ireland SZ
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   m-Allele M-Allele m/m
(frequency)
m/M
(frequency)
M/M
(frequency)
 Caucasian
ERBB4_IVS12-15C>T Ireland SZ
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
ERBB4_IVS12-15C>T UK (Cardiff full I) SZ
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
ERBB4_IVS12-15C>T Overlaps with Norton, 2006 UK (Cardiff full I) SZ
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   m-Allele M-Allele m/m
(frequency)
m/M
(frequency)
M/M
(frequency)
 Caucasian
ERBB4_IVS16+23T>C Ireland SZ
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
ERBB4_IVS16+23T>C UK (Cardiff) SZ
CTR
0.07
0.07
0.93
0.93
2 (0.005)
2 (0.005)
48 (0.130)
48 (0.130)
318 (0.864)
318 (0.864)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   m-Allele M-Allele m/m
(frequency)
m/M
(frequency)
M/M
(frequency)
 Caucasian
ERBB4_IVS16-24[A] UK (Cardiff) SZ
CTR
0.09
0.10
0.91
0.90
3 (0.008)
4 (0.011)
60 (0.163)
66 (0.179)
305 (0.829)
298 (0.810)
ERBB4_IVS16-24[A] Ireland SZ
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   m-Allele M-Allele m/m
(frequency)
m/M
(frequency)
M/M
(frequency)
 Caucasian
ERBB4_IVS17-102[G] Ireland SZ
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
ERBB4_IVS17-102[G] UK (Cardiff) SZ
CTR
0.10
0.09
0.90
0.91
4 (0.011)
3 (0.008)
66 (0.179)
60 (0.163)
298 (0.810)
305 (0.829)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   m-Allele M-Allele m/m
(frequency)
m/M
(frequency)
M/M
(frequency)
 Caucasian
ERBB4_IVS2+67G>C Ireland SZ
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
ERBB4_IVS2+67G>C UK (Cardiff full I) SZ
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
ERBB4_IVS2+67G>C Overlaps with Norton, 2006 UK (Cardiff full I) SZ
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   m-Allele M-Allele m/m
(frequency)
m/M
(frequency)
M/M
(frequency)
 Caucasian
ERBB4_IVS20-50G>A Ireland SZ
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
ERBB4_IVS20-50G>A UK (Cardiff) SZ
CTR
0.31
0.30
0.69
0.70
35 (0.095)
33 (0.090)
158 (0.429)
155 (0.421)
175 (0.476)
180 (0.489)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   m-Allele M-Allele m/m
(frequency)
m/M
(frequency)
M/M
(frequency)
 Caucasian
ERBB4_IVS25+63A>G UK (Cardiff) SZ
CTR
0.34
0.36
0.66
0.64
43 (0.117)
48 (0.130)
165 (0.448)
169 (0.459)
160 (0.435)
151 (0.410)
ERBB4_IVS25+63A>G Ireland SZ
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   m-Allele M-Allele m/m
(frequency)
m/M
(frequency)
M/M
(frequency)
 Caucasian
ERBB4_IVS25-92C>T Ireland SZ
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
ERBB4_IVS25-92C>T UK (Cardiff) SZ
CTR
0.41
0.40
0.59
0.60
62 (0.168)
59 (0.160)
178 (0.484)
177 (0.481)
128 (0.348)
132 (0.359)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   m-Allele M-Allele m/m
(frequency)
m/M
(frequency)
M/M
(frequency)
 Caucasian
ERBB4_IVS3+58A>G UK (Cardiff) SZ
CTR
0.20
0.23
0.80
0.77
15 (0.041)
20 (0.054)
118 (0.321)
130 (0.353)
235 (0.639)
218 (0.592)
ERBB4_IVS3+58A>G Ireland SZ
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   m-Allele M-Allele m/m
(frequency)
m/M
(frequency)
M/M
(frequency)
 Caucasian
ERBB4_IVS5-67A>G Ireland SZ
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
ERBB4_IVS5-67A>G UK (Cardiff) SZ
CTR
0.38
0.40
0.62
0.60
53 (0.144)
59 (0.160)
173 (0.470)
177 (0.481)
142 (0.386)
132 (0.359)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
rs1482381 UK (Cardiff) SZ
CTR
0.17
0.15
0.83
0.85
11 (0.030)
8 (0.022)
104 (0.283)
94 (0.255)
253 (0.688)
266 (0.723)
rs1482381 Ireland SZ
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   m-Allele M-Allele m/m
(frequency)
m/M
(frequency)
M/M
(frequency)
 Caucasian
rs1905139 Ireland SZ
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
rs1905139 UK (Cardiff) SZ
CTR
0.48
0.48
0.52
0.52
85 (0.231)
85 (0.231)
184 (0.500)
184 (0.500)
99 (0.269)
99 (0.269)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   m-Allele M-Allele m/m
(frequency)
m/M
(frequency)
M/M
(frequency)
 Caucasian
rs1851185 UK (Cardiff full II) SZ
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
rs2371277 UK (Cardiff full II) SZ
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   m-Allele M-Allele m/m
(frequency)
m/M
(frequency)
M/M
(frequency)
 Caucasian
rs4673629 UK (Cardiff full II) SZ
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   m-Allele M-Allele m/m
(frequency)
m/M
(frequency)
M/M
(frequency)
 Caucasian
rs6435661 UK (Cardiff full II) SZ
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   m-Allele M-Allele m/m
(frequency)
m/M
(frequency)
M/M
(frequency)
 Caucasian
rs6705698 UK (Cardiff full II) SZ
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   T-Allele C-Allele T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
 Caucasian
rs6725181 UK (Cardiff full II) SZ
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
rs6745717 UK (Cardiff full II) SZ
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   G-Allele A-Allele G/G
(frequency)
G/A
(frequency)
A/A
(frequency)
 Caucasian
rs6752616 UK (Cardiff full II) SZ
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   m-Allele M-Allele m/m
(frequency)
m/M
(frequency)
M/M
(frequency)
 Caucasian
rs6758038 UK (Cardiff full II) SZ
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   m-Allele M-Allele m/m
(frequency)
m/M
(frequency)
M/M
(frequency)
 Caucasian
rs7419602 UK (Cardiff full II) SZ
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   m-Allele M-Allele m/m
(frequency)
m/M
(frequency)
M/M
(frequency)
 Caucasian
rs7424835 UK (Cardiff full II) SZ
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   m-Allele M-Allele m/m
(frequency)
m/M
(frequency)
M/M
(frequency)
 Caucasian
rs7425341 UK (Cardiff full II) SZ
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   G-Allele T-Allele G/G
(frequency)
G/T
(frequency)
T/T
(frequency)
 Caucasian
rs7597007 UK (Cardiff full II) SZ
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   m-Allele M-Allele m/m
(frequency)
m/M
(frequency)
M/M
(frequency)
 Caucasian
rs9288438 UK (Cardiff full II) SZ
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).
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