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, the Brain and Behavior Research Fund, and was created with funding from the
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Printable version
SZGene - Gene overview of all published SZ-association studies for ERBB4
Gene:
ERBB4
(HER4; p180erbB4)
Protein:
v-erb-a erythroblastic leukemia viral oncogene homolog 4
(receptor tyrosine-protein kinase erbB-4; tyrosine kinase-type cell surface receptor HER4; avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4; v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4)
Chromosome:
2
(View:
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
X
Y
MT
)
Status:
Updated 21 October 2010
1. Case-Control Studies (by ethnic group)
SZ Cases
Normal Controls
Study
Population
Source
# Polys
# Subjects
(% women)
DX
Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
Comment
Caucasian
Benzel, 2007
UK
CL
109
(detail)
396
(28%)
U
-
44 + 14
(-)
1342
(46%)
-
Positive
Betcheva, 2009
Bulgaria
CL
4
(detail)
185
(-)
IV
-
-
184
(-)
-
Negative
Jungerius, 2007
Netherlands
CL
24
(detail)
310
(-)
IV
-
-
880
(-)
-
Negative
Norton, 2006
Ireland
CL
14
(detail)
290
(-)
IIIR
-
-
634
(-)
-
Negative
Norton, 2006
UK (Cardiff)
CL
12
(detail)
368
(28%)
IV
-
43.8 + 13.1
(-)
368
(29%)
42.6 + 11.9
(-)
Positive
Norton, 2006
UK (Cardiff full I)
CL
2
(detail)
703
(31%)
IV
-
-
703
(33%)
-
Negative
Norton, 2006
UK (Cardiff full II)
CL
14
(detail)
691
(-)
IV
-
-
710
(-)
-
Negative
Norton, 2006
Overlaps with
Norton, 2006 UK (Cardiff full I)
CL
2
(detail)
368
(28%)
IV
-
43.8 + 13.1
(-)
368
(29%)
42.6 + 11.9
(-)
n.a.
Silberberg, 2006
Israel
CL
19
(detail)
59
(-)
IV
-
38.6 + 9.5
(18-65)
130
(-)
-
Positive
African Descent
Shi, 2009
USA (GWAS)
CL,PO
1
(detail)
1286
(38%)
M
20.9 + 6.8
(-)
42.7 + 10.4
(-)
973
(61%)
45.6 + 13.1
(-)
Positive
Asian
Lu, 2010
Taiwan
CL
13
(detail)
227
(49%)
IV
-
45 + 8
(-)
223
(57%)
51 + 10.2
(-)
Positive
Shiota, 2008
Japan
CL
5
(detail)
416
(46%)
IV
-
45 + 14.7
(-)
520
(46%)
37.5 + 11.3
(-)
Negative
So, 2009
China
CL,PO
9
(detail)
489
(-)
IV
-
-
519
(-)
-
Positive
Contact us
if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
Affecteds
Unaffecteds
Study
Population
# Polys
# Families
# Subjects
(% women)
DX
Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
Comment
Caucasian
Nicodemus, 2006
USA (I)
7
(detail)
296
-
IV
-
-
-
-
Positive
Nicodemus, 2006
USA (II)
3
(detail)
71
-
IV
-
-
-
-
Positive
African Descent
Nicodemus, 2006
USA (III)
3
(detail)
51
-
IV
-
-
-
-
Positive
Contact us
if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:
Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:
Number of polymorphisms tested per gene and per sample.
Onset Age and Age:
Mean or median age at onset or examination, respectively.
DX:
Criteria used to determine SZ diagnosis -> "IIIR"(DSM-IIIR), "IV" (DSM-IV), "9" (ICD-9), "10" (ICD-10), "M" (Mixed), "RDC" (Research Diagnostic Criteria), "U" (Unknown).
Result:
Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-)
: Either no data provided or in case of overlap, data included in original study.
SZGene Recent Updates
SZGene Stats
Studies: 1727
Genes: 1008
Polymorphisms: 8788
Meta-analyses: 287
ALSGene
AlzGene
MSGene
PDGene
SZGene
An up-to-date collection of all published genetic association studies.
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