SZGene

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SZGene - Gene overview of all published SZ-association studies for ERBB4

Gene:

ERBB4 (HER4; p180erbB4)

Protein:

v-erb-a erythroblastic leukemia viral oncogene homolog 4 (receptor tyrosine-protein kinase erbB-4; tyrosine kinase-type cell surface receptor HER4; avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4; v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4)

Chromosome:

2 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 21 October 2010

1. Case-Control Studies (by ethnic group)
				SZ Cases				Normal Controls
Study	Population	Source	# Polys	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result	Comment
Caucasian
Benzel, 2007	UK	CL	109 (detail)	396 (28%)	U	-	44 + 14 (-)	1342 (46%)	-	Positive
Betcheva, 2009	Bulgaria	CL	4 (detail)	185 (-)	IV	-	-	184 (-)	-	Negative
Jungerius, 2007	Netherlands	CL	24 (detail)	310 (-)	IV	-	-	880 (-)	-	Negative
Norton, 2006	Ireland	CL	14 (detail)	290 (-)	IIIR	-	-	634 (-)	-	Negative
Norton, 2006	UK (Cardiff)	CL	12 (detail)	368 (28%)	IV	-	43.8 + 13.1 (-)	368 (29%)	42.6 + 11.9 (-)	Positive
Norton, 2006	UK (Cardiff full I)	CL	2 (detail)	703 (31%)	IV	-	-	703 (33%)	-	Negative
Norton, 2006	UK (Cardiff full II)	CL	14 (detail)	691 (-)	IV	-	-	710 (-)	-	Negative
Norton, 2006	Overlaps with Norton, 2006 UK (Cardiff full I)	CL	2 (detail)	368 (28%)	IV	-	43.8 + 13.1 (-)	368 (29%)	42.6 + 11.9 (-)	n.a.
Silberberg, 2006	Israel	CL	19 (detail)	59 (-)	IV	-	38.6 + 9.5 (18-65)	130 (-)	-	Positive
African Descent
Shi, 2009	USA (GWAS)	CL,PO	1 (detail)	1286 (38%)	M	20.9 + 6.8 (-)	42.7 + 10.4 (-)	973 (61%)	45.6 + 13.1 (-)	Positive
Asian
Lu, 2010	Taiwan	CL	13 (detail)	227 (49%)	IV	-	45 + 8 (-)	223 (57%)	51 + 10.2 (-)	Positive
Shiota, 2008	Japan	CL	5 (detail)	416 (46%)	IV	-	45 + 14.7 (-)	520 (46%)	37.5 + 11.3 (-)	Negative
So, 2009	China	CL,PO	9 (detail)	489 (-)	IV	-	-	519 (-)	-	Positive

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

2. Family-Based Studies (by ethnic group)
				Affecteds				Unaffecteds
Study	Population	# Polys	# Families	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result	Comment
Caucasian
Nicodemus, 2006	USA (I)	7 (detail)	296	-	IV	-	-	-	-	Positive
Nicodemus, 2006	USA (II)	3 (detail)	71	-	IV	-	-	-	-	Positive
African Descent
Nicodemus, 2006	USA (III)	3 (detail)	51	-	IV	-	-	-	-	Positive

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine SZ diagnosis -> "IIIR"(DSM-IIIR), "IV" (DSM-IV), "9" (ICD-9), "10" (ICD-10), "M" (Mixed), "RDC" (Research Diagnostic Criteria), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.


SZGene Recent Updates
SZGene Stats Studies: 1727 Genes: 1008 Polymorphisms: 8788 Meta-analyses: 287





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