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SZGene - Gene overview of all published SZ-association studies for DRD2    
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 Gene: DRD2  (D2R; D2DR)  Entrez Gene    View on PDGene
 Protein: dopamine receptor D2  (seven transmembrane helix receptor)  ProteinLink
 Chromosome: 11   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 21 October 2010
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      SZ Cases Normal Controls    
Study Population Source # Polys # Subjects
(% women)		 DX Onset Age
(range)		 Age
(range)		 # Subjects
(% women)		 Age
(range)		 Result Comment
 Caucasian
Asherson, 1994
 UK CL  1  (detail)  112
(-)		IIIR--64
(-)		-Negative
Bertolino, 2008
 Italy CL  3  (detail)  196
(25%)		IV-33.5 + 12.8
(-)		249
(61%)		36.6 + 11.5
(-)		Positive
Betcheva, 2009
 Bulgaria (I) CL  4  (detail)  185
(-)		IV--184
(-)		-Positive
Betcheva, 2009
 Bulgaria (II) CL  2  (detail)  70
(-)		IV--372
(-)		-Positive
Breen, 1999
 UK CL  1  (detail)  439
(-)		M--437
(-)		-Positive
Campion, 1994
 France CL  1  (detail)  80
(-)		IIIR--80
(-)		-Negative
Comings, 1991
 USA CL  1  (detail)  87
(-)		III--314
(-)		-Negative
Crawford, 1996
 USA CL  1  (detail)  84
(-)		IIIR--81
(-)		-Negative
Dollfus, 1996
 France CL  1  (detail)  62
(-)		M--161
(-)		-Negative
Dubertret, 2001
 Overlaps with
Dubertret, 2010		 CL  2  (detail)  50
(26%)		IV20.6 + 3.1
(-)		-50
(22%)		-n.a.
Dubertret, 2004
 Overlaps with
Dubertret, 2010		 CL  6  (detail)  103
(21%)		IV20.7 + 8
(-)		-83
(19%)		-n.a.
Dubertret, 2010
 France CL  8  (detail)  252
(40%)		IV27.5
(-)		40.4
(-)		142
(54%)		73.6 + 8.3
(-)		Positive
Hall, 2007
 Overlaps with
Jonsson, 2003		 CL  1  (detail)  103
(38%)		M-42.4 + 11.5
(-)		89
(33%)		39.2 + 11.5
(-)		n.a.
Hanninen, 2006
 Finland CL  1  (detail)  188
(45%)		IV27 + 8.9
(-)		43.1 + 12
(18-76)		384
(46%)		44.4 + 11.2
(19-65)		Positive
Hoenicka, 2006
 Spain CL  1  (detail)  131
(42%)		IV--364
(-)		-Positive
Hoogendoorn, 2005
 Netherlands CL  2  (detail)  208
(-)		IV--288
(-)		-Negative
Jonsson, 1996
 Sweden CL  1  (detail)  118
(36%)		IIIR-45.8
(20-90)		78
(42%)		38.7
(29-56)		Negative
Jonsson, 1999
 Sweden CL  1  (detail)  129
(36%)		IIIR-44.6 + 17.3
(-)		179
(52%)		45.3 + 15.9
(-)		Positive
Jonsson, 2003
 Sweden CL  1  (detail)  173
(37%)		M-44 + 15.6
(-)		236
(37%)		39.8 + 10.3
(-)		Positive
Kampman, 2003
 Finland CL  1  (detail)  93
(-)		IV--94
(-)		-Negative
Lafuente, 2008
 Spain CL  3  (detail)  243
(46%)		IV-34 + 13
(-)		291
(62%)		61.7 + 11
(-)		Positive
Laurent, 1994
 France CL  1  (detail)  113
(30%)		IIIR-42 + 0.6
(-)		184
(40%)		49 + 0.5
(-)		Negative
Lawford, 2005
 Australia CL  1  (detail)  153
(13%)		IV-36.2 + 12.3
(18-65)		148
(29%)		36.8 + 12.8
(-)		Positive
Li, 1998
 UK CL  1  (detail)  151
(56%)		M-29.4 + 10.9
(15-65)		145
(158%)		-Negative
Mas, 2009
 Spain CL  13  (detail)  159
(-)		IV--373
(54%)		51.9 + 19
(-)		Negative
Meda, 2009
 USA CL  2  (detail)  31
(-)		IV--35
(-)		-Negative
Monakhov, 2008
 Russia CL  3  (detail)  311
(48%)		IV25.4 + 8.9
(-)		35.3 + 12.5
(-)		364
(62%)		31.7 + 12.7
(-)		Positive
Nothen, 1993
 Germany CL  1  (detail)  60
(33%)		IIIR25.2 + 8
(14-46)		34.8 + 11
(-)		60
(47%)		28.2 + 5.2
(-)		Negative
Nothen, 1994
 Germany CL  1  (detail)  179
(-)		III--138
(-)		-Negative
Parsons, 2007
 Spain CL  2  (detail)  119
(34%)		IV-41.2 + 13.9
(-)		165
(51%)		26.8 + 5.4
(-)		Positive
Saiz, 2009
 Spain CL  1  (detail)  288
(40%)		IV-36.3 + 12.4
(-)		421
(49%)		40.6 + 11.3
(-)		Positive
Sanders, 1993
 USA CL  1  (detail)  55
(9%)		IIIR26 + 8
(13-56)		44 + 14
(21-71)		51
(6%)		60 + 10
(37-78)		Negative
Sanders, 2008
 USA, Australia CL  31  (detail)  1870
(31%)		IV--2002
(53%)		-Negative
Sasaki, 1996
 USA, Canada, Italy CL  1  (detail)  273
(33%)		IIIR-32 + 9
(-)		255
(50%)		-Negative
Serretti, 2000
 Italy CL  1  (detail)  366
(-)		IV--267
(52%)		46.6 + 15.9
(-)		Negative
Shaikh, 1994
 UK CL  1  (detail)  140
(-)		III--100
(-)		-Positive
Sobell, 1994
 USA CL  1  (detail)  338
(-)		III--1914
(-)		-Negative
Spurlock, 1998
 UK CL  1  (detail)  97
(-)		IIIR--106
(-)		-Negative
Spurlock, 1998
 Italy CL  1  (detail)  103
(-)		IIIR--96
(-)		-Negative
Spurlock, 1998
 Ireland CL  1  (detail)  34
(-)		IIIR--89
(-)		-Negative
Spurlock, 1998
 Austria CL  1  (detail)  72
(-)		IIIR--57
(-)		-Negative
Stober, 1998
 Germany CL  1  (detail)  260
(40%)		1026.9 + 9.4
(-)		-290
(45%)		29.3 + 9.7
(-)		Negative
Talkowski, 2008
 USA CL  5  (detail)  328
(-)		IV--501
(-)		-Negative
Tallerico, 1999
 USA, Canada CL  1  (detail)  50
(-)		IIIR--51
(-)		-Negative
Verga, 1997
 Italy CL  1  (detail)  103
(41%)		IIIR22.8 + 7.1
(-)		37.9 + 10.5
(-)		97
(51%)		53.2 + 16.4
(-)		Negative
Virgos, 2001
 Spain PO  1  (detail)  262
(40%)		9-61.4
(19-90)		278
(39%)		54.2
(21-90)		Positive
 Asian
Arinami, 1994
 Overlaps with
Arinami, 1996		 CL  1  (detail)  156
(37%)		IIIR-48.1
(17-75)		300
(-)		45.2
(31-60)		n.a.
Arinami, 1996
 Overlaps with
Itokawa, 1993		 CL  1  (detail)  291
(-)		M--579
(-)		-Trend
Arinami, 1997
 Japan CL  2  (detail)  260
(46%)		IIIR22.4
(12-39)		44.4
(19-81)		312
(45%)		48.7
(29-75)		Positive
Chen, 1996
 Taiwan CL  1  (detail)  114
(50%)		IIIR-40
(-)		88
(60%)		27.5
(-)		Negative
Fan, 2009
 China CL  3  (detail)  421
(-)		IV-30.7 + 10.7
(15-70)		404
(-)		28.1 + 8.1
(16-60)		Positive
Fujiwara, 1997
 Japan CL  1  (detail)  52
(-)		M--26
(-)		-Negative
Harano, 1997
 Japan CL  1  (detail)  70
(34%)		IIIR-47 + 10
(-)		101
(54%)		67 + 15
(-)		Negative
Hattori, 1994
 Japan CL  1  (detail)  100
(50%)		IIIR--100
(50%)		-Negative
Himei, 2002
 Japan CL  2  (detail)  190
(37%)		IV-53.1 + 11.5
(-)		103
(49%)		33.1 + 10.8
(-)		Negative
Hokyo, 2010
 Japan CL  2  (detail)  407
(42%)		IV-54.7
(-)		384
(64%)		40.1
(-)		Negative
Hori, 2001
 Japan CL  2  (detail)  241
(49%)		IV-52.7 + 11.5
(-)		201
(50%)		54.7 + 6.8
(-)		Negative
Inada, 1999
 Japan CL  1  (detail)  234
(-)		IIIR--94
(-)		-Positive
Itokawa, 1993
 Japan CL  1  (detail)  50
(42%)		IIIR--110
(-)		-Negative
Kaneshima, 1997
 Japan CL  1  (detail)  78
(55%)		IV-36.3 + 10.1
(19-68)		112
(68%)		23 + 2.1
(18-30)		Negative
Luu, 2008
 Taiwan CL  1  (detail)  211
(47%)		IV-43
(-)		201
(55%)		42
(-)		Negative
Morimoto, 2002
 Japan CL  1  (detail)  48
(-)		III--48
(-)		-Negative
Nanko, 1994
 Overlaps with
Hattori, 1994		 CL  1  (detail)  100
(50%)		IIIR--100
(50%)		-n.a.
Ohara, 1996
 Japan CL  1  (detail)  153
(50%)		IV26.3 + 9.5
(-)		46.3 + 16
(-)		121
(58%)		34.4 + 14.1
(-)		Negative
Ohara, 1998
 Japan CL  1  (detail)  170
(48%)		IV26 + 9.7
(-)		43.5 + 16.1
(-)		121
(58%)		35.4 + 14.2
(-)		Positive
Tanaka, 1996
 Japan CL  1  (detail)  106
(48%)		IIIR-44.7 + 11.8
(15-70)		106
(41%)		45.8 + 25
(22-86)		Negative
 Other/Mixed
Behravan, 2008
 Iran CL  2  (detail)  38
(55%)		IV-42 + 12
(-)		63
(62%)		46 + 18
(-)		Negative
Cordeiro, 2009
 Brazil CL  1  (detail)  229
(35%)		IV-27.2 + 7.5
(19-64)		733
(32%)		31.8 + 9.1
(18-79)		Positive
Gejman, 1994
 USA CL  1  (detail)  106
(-)		M--125
(-)		-Negative
Gupta, 2009
 India CL  8  (detail)  254
(39%)		IV-29.2 + 7.6
(-)		225
(38%)		31 + 11
(-)		Positive
Kukreti, 2006
 Overlaps with
Gupta (2009)		 CL  2  (detail)  101
(45%)		IV25.3 + 7.3
(-)		-145
(-)		-n.a.
Pal, 1995
 India CL  1  (detail)  156
(37%)		IIIR--300
(-)		-Positive
Srivastava, 2010
 India CL  5  (detail)  215
(48%)		IV21.4 + 6.1
(-)		29.3 + 8.9
(-)		215
(40%)		34.6 + 12.4
(-)		Positive
Vijayan, 2007
 India CL  5  (detail)  213
(62%)		IV24.4 + 8
(-)		34.4 + 10.8
(-)		196
(-)		-Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds    
Study Population # Polys # Families # Subjects
(% women)		 DX Onset Age
(range)		 Age
(range)		 # Subjects
(% women)		 Age
(range)		 Result Comment
 Caucasian
Ambrosio, 2004
 Portugal  1  (detail)  9090
(36%)		IV--180
(50%)		-Negative
Dubertret, 2001
 Overlaps with
Dubertret, 2010 (CC)		  2  (detail)  5050
(26%)		IV--100
(50%)		-n.a.
Dubertret, 2004
 Overlaps with
Dubertret, 2010 (CC)		  4  (detail)  103103
(21%)		IV20.7 + 8
(-)		-206
(50%)		-n.a.
Dubertret, 2010
 Overlaps with
Dubertret, 2010 (CC)		  4  (detail)  108108
(20%)		IV----Positive
Fallin, 2005
 USA  5  (detail)  263274
(26%)		IV19.5 + 4.5
(-)		-548
(50%)		-Negative
Laurent, 1994
 France  1  (detail)  51-IIIR----Negative
Schindler, 2002
 Portugal  1  (detail)  7878
(38%)		IV--156
(50%)		-Positive
Talkowski, 2008
 USA  5  (detail)  150150
(50%)		IV--300
(50%)		-Negative
 Asian
Glatt, 2008
 Taiwan  24  (detail)  6161214
(-)		IV--1194
(-)		-Positive
Li, 1998
 China  1  (detail)  229229
(37%)		M-29.4 + 10.9
(15-65)		458
(50%)		-Negative
 Other/Mixed
Fanous, 2004
 USA  1  (detail)   544
(-)		IIIR--730
(-)		-Negative
Goldman, 1997
 USA  1  (detail)   5
(20%)		IIIR--455
(-)		-Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine SZ diagnosis ->  "IIIR"(DSM-IIIR), "IV" (DSM-IV), "9" (ICD-9), "10" (ICD-10), "M" (Mixed), "RDC" (Research Diagnostic Criteria), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
SZGene Recent Updates
SZGene Stats
Studies: 1727
Genes: 1008
Polymorphisms: 8788
Meta-analyses: 287
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