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SZGene - Gene overview of all published SZ-association studies for CHRNA7    
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 Gene: CHRNA7  (NACHRA7)  Entrez Gene    View on AlzGene   View on PDGene
 Protein: cholinergic receptor, nicotinic, alpha 7  (alpha7 nicotinic receptor subunit; a7 nicotinic acetylcholine receptor; nicotinic cholinergic receptor alpha 7; nicotinic acetylcholine alpha-7 subunit; alpha-7 nicotinic cholinergic receptor subunit; alpha 7 neuronal nicotinic acetylcholine receptor; cholinergic receptor, nicotinic, alpha polypeptide 7; neuronal nicotinic acetylcholine receptor alpha-7 subunit; nicotinic acetylcholine receptor alpha7 subunit precursor)  ProteinLink
 Chromosome: 15   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 21 October 2010
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      SZ Cases Normal Controls    
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Ancin, 2010
Spain CL  4  (detail)  510
(38%)
IV-37.8 + 17.2
(-)
793
(43%)
38.5 + 14.7
(-)
Negative
Gault, 2003
USA (I) CL  1  (detail)  127
(-)
IV--103
(-)
-Negative
Houy, 2004
France CL  3  (detail)  111
(29%)
IV-29.4 + 7.8
(-)
85
(53%)
36.2 + 9.5
(-)
Positive
Meda, 2009
USA CL  2  (detail)  31
(-)
IV--35
(-)
-Negative
Sanders, 2008
USA, Australia CL  18  (detail)  1870
(31%)
IV--2002
(53%)
-Negative
Stassen, 2000
Switzerland CL  2  (detail)  50
(30%)
10--129
(52%)
-Positive
Stephens, 2009
USA CL  5  (detail)  363
(-)
IV--99
(-)
-Positive
Zammit, 2007
UK CL  1  (detail)  750
(-)
IV--618
(-)
-Negative
 African Descent
Gault, 2003
USA (II) CL  1  (detail)  58
(-)
IV--55
(-)
-Negative
Stephens, 2009
USA CL  8  (detail)  105
(-)
IV--45
(-)
-Positive
 Asian
Fan, 2006
China PO  1  (detail)  432
(50%)
IIIR-43 + 17.5
(-)
284
(42%)
31 + 9.6
(-)
Negative
Iwata, 2006
China CL  9  (detail)  188
(-)
IV--188
(-)
-Negative
Joo, 2010
Korea CL  3  (detail)  254
(40%)
IV-35.5 + 8.2
(-)
349
(50%)
25.9 + 6.5
(-)
Negative
 Hispanic
Gault, 2003
USA (III) CL  1  (detail)  8
(-)
IV--8
(-)
-Negative
 Other/Mixed
Leonard, 2002
USA, Israel CL  4  (detail)  298
(-)
IV--165
(-)
-Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds    
Study Population # Polys # Families # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Xu, 2001
Portugal  1  (detail)  3141
(-)
III--97
(-)
-Positive
 Asian
Fan, 2006
China  1  (detail)  160160
(48%)
IIIR-23 + 6.4
(-)
320
(50%)
-Negative
 Other/Mixed
De Luca, 2004
Canada  1  (detail)  82-IV----Positive
Freedman, 2006
USA  5  (detail)   88
(-)
IIIR----Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine SZ diagnosis ->  "IIIR"(DSM-IIIR), "IV" (DSM-IV), "9" (ICD-9), "10" (ICD-10), "M" (Mixed), "RDC" (Research Diagnostic Criteria), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
SZGene Recent Updates
SZGene Stats
Studies: 1727
Genes: 1008
Polymorphisms: 8788
Meta-analyses: 287
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SZGene
An up-to-date collection of all published genetic association studies.
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