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SZGene - Gene overview of all published SZ-association studies for HTR2A    
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 Gene: HTR2A  (HTR2; 5-HT2A)  Entrez Gene    View on AlzGene   View on PDGene
 Protein: 5-hydroxytryptamine receptor 2A  (5-HT2 receptor; serotonin receptor 2A)  ProteinLink
 Chromosome: 13   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 22 October 2010
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      SZ Cases Normal Controls    
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Anttila, 2007
Finland CL  1  (detail)  94
(51%)
IV30 + 9.9
(-)
45.9 + 10.9
(-)
392
(46%)
44.4 + 11.1
(-)
Negative
Arranz, 1995
UK CL  1  (detail)  149
(53%)
IIIR--99
(-)
-Negative
Arranz, 1996a
UK CL  1  (detail)  153
(-)
IIIR--178
(-)
-Negative
Arranz, 1996b
UK CL  1  (detail)  74
(-)
IIIR--183
(-)
-Negative
Arranz, 1998
UK CL  1  (detail)  160
(-)
IIIR--178
(-)
-Negative
Arranz, 1998
Overlaps with
Arranz, 1996a
CL  1  (detail)  160
(-)
IIIR--178
(-)
-n.a.
Baritaki, 2004
Greece CL  1  (detail)  114
(41%)
IV25.5 + 9.2
(14-60)
50.6 + 13.3
(-)
192
(39%)
45.1 + 8.7
(-)
Positive
Bertola, 2007
Spain CL  1  (detail)  246
(-)
IV--315
(-)
-Negative
Betcheva, 2009
Bulgaria CL  2  (detail)  185
(-)
IV--184
(-)
-Negative
Boke, 2007
Turkey CL  1  (detail)  127
(41%)
IV-39.6 + 9
(-)
100
(38%)
45.7 + 15
(-)
Negative
Czerski, 2003
Poland CL  1  (detail)  235
(40%)
M22.9 + 5.8
(-)
30.6 + 10.5
(-)
344
(60%)
41 + 11
(-)
Negative
Domingeuz, 2006
Spain CL  27  (detail)  260
(35%)
IV--354
(55%)
-Trend
Erdmann, 1996
Germany CL  4  (detail)  323
(-)
IIIR--253
(-)
-Positive
Golimbet, 2002
Overlaps with
Golimbet, 2007
CL  1  (detail)  375
(55%)
10--157
(59%)
32.6 + 13.8
(-)
n.a.
Golimbet, 2007
Russia CL  1  (detail)  919
(59%)
1026.1 + 10.3
(-)
38.2 + 14.1
(-)
500
(51%)
37.7 + 13.7
(-)
Positive
Hawi, 1997
Ireland CL  1  (detail)  247
(-)
U--249
(-)
-Negative
He, 1999
UK CL  1  (detail)  253
(-)
IIIR--244
(46%)
-Negative
Herken, 2003a
Turkey CL  2  (detail)  143
(35%)
IV-32.3 + 9.1
(-)
79
(-)
-Negative
Herken, 2003b
Overlaps with
Herken, 2003a
CL  1  (detail)  141
(35%)
IV-34.1 + 9.8
(-)
79
(35%)
30.5 + 6.1
(-)
n.a.
Jonsson, 1996
Sweden CL  1  (detail)  118
(-)
IIIR--99
(-)
-Negative
Joober, 1999
Canada CL  1  (detail)  102
(26%)
IV--90
(47%)
44.6 + 12.8
(-)
Trend
Melkersson, 2009
Sweden CL  4  (detail)  94
(50%)
IV26
(-)
44 + 9
(-)
57
(74%)
45 + 11
(-)
Positive
Penas-Lledo, 2007
Spain CL  2  (detail)  114
(11%)
IV-55 + 12
(-)
142
(50%)
30 + 11
(-)
Positive
Rao, 1998
Overlaps with
Nimgaonkar, 1996
CL  1  (detail)  80
(40%)
IV-37.4 + 10
(-)
127
(66%)
30 + 10.3
(-)
n.a.
Saiz, 2007
Spain CL  2  (detail)  227
(40%)
IV-35.7 + 11.7
(-)
420
(49%)
40.6 + 11.3
(-)
Negative
Sanders, 2008
USA, Australia CL  30  (detail)  1870
(31%)
IV--2002
(53%)
-Negative
Spurlock, 1998
UK CL  1  (detail)  115
(32%)
IIIR-46 + 12
(-)
115
(32%)
45 + 12
(-)
Negative
Vaquero Lorenzo, 2006
Spain CL  1  (detail)  188
(50%)
IV-36 + 11.4
(-)
440
(42%)
43.1 + 14.1
(-)
Positive
Verga, 1997
Overlaps with
Williams, 1996
CL  1  (detail)  100
(40%)
IIIR23.1 + 7.5
(-)
50.7 + 16.7
(-)
103
(50%)
38.1 + 12.1
(-)
n.a.
Virgos, 2001
Spain CL  1  (detail)  262
(40%)
9-61.4
(19-90)
278
(39%)
54.2
(21-90)
Negative
Williams, 1996
Austria CL  1  (detail)  72
(-)
IIIR--57
(-)
-Positive
Williams, 1996
France CL  1  (detail)  101
(-)
IIIR--122
(-)
-Positive
Williams, 1996
Germany CL  1  (detail)  100
(-)
IIIR--100
(-)
-Positive
Williams, 1996
Ireland CL  1  (detail)  37
(-)
IIIR--89
(-)
-Positive
Williams, 1996
Italy CL  1  (detail)  100
(-)
IIIR--103
(-)
-Positive
Williams, 1996
Sweden CL  1  (detail)  67
(-)
IIIR--74
(-)
-Positive
Williams, 1996
UK CL  1  (detail)  94
(-)
IIIR--94
(-)
-Positive
 African Descent
Rao, 1998
Overlaps with
Nimgaonkar, 1996
CL  1  (detail)  47
(43%)
IV-35.2 + 9.3
(-)
37
(57%)
30 + 8
(-)
n.a.
 Asian
Chen, 1997
Taiwan CL  1  (detail)  177
(46%)
IIIR-47
(-)
98
(51%)
45
(-)
Negative
Chen, 2001
China CL  1  (detail)  471
(29%)
IV-42.3 + 10.2
(18-60)
523
(41%)
41.9 + 9.7
(-)
Negative
He, 1999
China CL  1  (detail)  202
(-)
IIIR--202
(55%)
-Negative
Inayama, 1996
Japan CL  1  (detail)  62
(42%)
IIIR26.5 + 7.5
(-)
45 + 11.8
(-)
96
(60%)
37.1 + 14.4
(-)
Positive
Ishigaki, 1996
Japan CL  1  (detail)  158
(49%)
IV26 + 9.7
(-)
44.6 + 16.2
(-)
150
(57%)
37 + 15.4
(-)
Negative
Kim, 1999
Korea CL  1  (detail)  127
(36%)
IV27 + 8.5
(-)
38 + 11.4
(-)
100
(42%)
36 + 7.8
(-)
Negative
Lin, 1999
China CL  1  (detail)  97
(-)
IV--101
(-)
-Negative
Ohara, 1999
Japan CL  1  (detail)  119
(48%)
IV25.3 + 9.2
(-)
43.7 + 15.8
(-)
106
(-)
-Negative
Pae, 2005
Korea CL  1  (detail)  111
(52%)
IV-30.3 + 9.4
(-)
172
(53%)
25 + 9.9
(-)
Negative
Sasaki, 1996
Japan CL  1  (detail)  121
(-)
IIIR--162
(-)
-Negative
Shinkai, 1998
Japan CL  1  (detail)  106
(41%)
IV-54.5 + 12.2
(16-74)
109
(65%)
54.6 + 6.8
(45-72)
Negative
Tan, 2001
Overlaps with
Tan, 2002
CL  1  (detail)  221
(23%)
IV-51.5 + 9
(-)
97
(34%)
-n.a.
Tan, 2002
China CL  1  (detail)  286
(-)
IV--94
(-)
-Negative
Tay, 1997
Singapore CL  1  (detail)  101
(0%)
9--103
(0%)
-Positive
Tsunoka, 2010
Japan CL  2  (detail)  738
(46%)
10-41.2 + 13.8
(-)
802
(56%)
37.6 + 14.3
(-)
Negative
Yoshihara, 2000
Japan CL  1  (detail)  31
(-)
U--55
(-)
-Negative
Zhang, 2004
China (I) CL  1  (detail)  158
(40%)
IV26.7 + 7.5
(-)
55.2 + 10.2
(29-79)
173
(57%)
56.7 + 10.6
(25-92)
Negative
Zhang, 2004
China (II) CL  1  (detail)  133
(46%)
IV25.2 + 7.3
(-)
40.3 + 10.4
(28-65)
134
(40%)
41 + 9.5
(24-82)
Negative
 Other/Mixed
Araga, 2002
India CL  1  (detail)  100
(39%)
IV--100
(-)
-Positive
Correa, 2007
Brazil CL  1  (detail)  129
(39%)
IV--85
(47%)
-Negative
Haider, 2002
Kuwait CL  1  (detail)  80
(25%)
1042.2
(-)
41.9
(19-69)
109
(-)
-Negative
Kouzmenko, 1999
Australia CL  1  (detail)  58
(-)
IIIR--64
(-)
-Negative
Nimgaonkar, 1996
USA CL  1  (detail)  174
(46%)
IIIR-35.9 + 9.9
(-)
239
(63%)
31.1 + 10.5
(-)
Negative
Segman, 2001
Israel CL  3  (detail)  121
(-)
IV--96
(46%)
-Trend
Semwal, 2002
India CL  2  (detail)  536
(44%)
IV-22.8 + 7
(-)
936
(47%)
32.9 + 12.7
(-)
Positive
Tee, 2010
Malaysia CL  1  (detail)  289
(35%)
M-45.5 + 13.6
(-)
130
(44%)
36.8 + 11.2
(-)
Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds    
Study Population # Polys # Families # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
De Luca, 2007
Canada  1  (detail)  8181
(-)
IV--162
(50%)
-Negative
Fallin, 2005
USA  9  (detail)  263274
(26%)
IV19.5 + 4.5
(-)
-548
(50%)
-Negative
Golimbet, 2002
Russia  1  (detail)   375
(55%)
10--104
(42%)
43.7 + 14.7
(-)
Negative
Golimbet, 2007
Russia  1  (detail)  134919
(59%)
1026.1 + 10.3
(-)
38.2 + 14.1
(-)
330
(51%)
46.3 + 13.1
(-)
Positive
Spurlock, 1998
Overlaps with
Spurlock, 1998
 1  (detail)  6363
(32%)
IIIR-35 + 9
(-)
126
(50%)
-n.a.
Verga, 1997
Italy  1  (detail)  6767
(-)
IIIR--134
(50%)
-Negative
Wei, 2005
UK  1  (detail)  124124
(31%)
U-29.3 + 7
(-)
248
(50%)
-Negative
 Asian
He, 1999
China  1  (detail)  112112
(-)
IV--224
(50%)
-Negative
 Other/Mixed
Benmesaoud, 2008
Algeria  1  (detail)  100-IV----Positive
Fanous, 2004
USA  2  (detail)   651
(-)
IIIR--709
(-)
-Negative
Malhotra, 1996
USA  1  (detail)  5252
(-)
IIIR--104
(50%)
-Negative
Semwal, 2001
India  2  (detail)  179179
(42%)
IV22.1 + 6.3
(-)
---Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine SZ diagnosis ->  "IIIR"(DSM-IIIR), "IV" (DSM-IV), "9" (ICD-9), "10" (ICD-10), "M" (Mixed), "RDC" (Research Diagnostic Criteria), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
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Studies: 1727
Genes: 1008
Polymorphisms: 8788
Meta-analyses: 287
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