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SZGene - Gene overview of all published SZ-association studies for NRG1    
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 Gene: NRG1  (GGF; HGL; HRG; NDF; ARIA; GGF2; HRG1; HRGA; SMDF)  Entrez Gene    View on AlzGene
 Protein: neuregulin 1  (glial growth factor; neu differentiation factor; sensory and motor neuron derived factor; heregulin, alpha (45kD, ERBB2 p185-activator))  ProteinLink
 Chromosome: 8   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 23 November 2010
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      SZ Cases Normal Controls    
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Alaerts, 2009
Sweden CL  37  (detail)  486
(37%)
IV248 + 73
(-)
531 + 151
(-)
514
(54%)
58 + 13
(-)
Positive
Bakker, 2004
Netherlands CL  3  (detail)  282
(-)
IV--585
(-)
-Positive
Benzel, 2007
UK CL  94  (detail)  396
(28%)
U-44 + 14
(-)
1342
(46%)
-Positive
Bramon, 2008
UK CL  3  (detail)  64
(25%)
IV-36 + 10
(-)
35
(54%)
41 + 14.4
(-)
Negative
Corvin, 2004
Ireland CL  20  (detail)  243
(-)
IV--222
(-)
-Positive
Dutt, 2009
UK, Ireland CL  3  (detail)  83
(-)
IV--57
(-)
-Negative
Hall, 2007
Overlaps with
Jonsson, 2009 (Sweden)
CL  1  (detail)  103
(38%)
M-42.4 + 11.5
(-)
89
(33%)
39.2 + 11.5
(-)
n.a.
Hanninen, 2007
Finland CL  1  (detail)  113
(39%)
IV23.7 + 6.1
(-)
39.7 + 12
(18-76)
393
(46%)
44.5 + 11.1
(19-65)
Positive
Ingason, 2006
Denmark CL  5  (detail)  325
(-)
10--353
(-)
-Negative
Jonsson, 2009
Denmark, Norway, Sweden CL  12  (detail)  837
(42%)
M26.5
(-)
45.7
(-)
1473
(42%)
44.1
(-)
Negative
Jungerius, 2007
Netherlands CL  17  (detail)  310
(-)
IV--880
(-)
-Negative
Kampman, 2004
Finland CL  1  (detail)  94
(-)
IV--395
(46%)
44.5 + 11.1
(19-65)
Negative
Lachman, 2006
USA CL  4  (detail)  177
(-)
M--164
(-)
-Negative
Nicodemus, 2009
USA CL  1  (detail)  296
(-)
IV--365
(-)
-Positive
Pedrosa, 2009
USA CL  1  (detail)  176
(31%)
M-42 + 10
(-)
175
(45%)
48 + 13
(-)
Positive
Petryshen, 2005
Portugal, USA CL  44  (detail)  321
(-)
IV--242
(46%)
-Positive
Rethelyi, 2009
Hungary CL  4  (detail)  280
(54%)
IV28.6
(-)
37.6
(-)
230
(57%)
39.9
(-)
Positive
Sanders, 2008
USA, Australia CL  216  (detail)  1870
(31%)
IV--2002
(53%)
-Negative
Shaikh, 2010
Overlaps with
Dutt, 2009
CL  3  (detail)  70
(-)
IV--204
(63%)
40.1 + 13.2
(18-65)
Negative
Squassina, 2010
Italy CL  5  (detail)  171
(30%)
IV-36.7 + 9.7
(-)
349
(36%)
38.6 + 10.1
(-)
Negative
Stefansson, 2002
Iceland CL  7  (detail)  478
(-)
RDC--394
(-)
-Positive
Stefansson, 2003
UK (Scotland) PO  7  (detail)  609
(-)
IIIR--618
(-)
-Positive
Thomson, 2006
UK (Scotland) CL  38  (detail)  386
(28%)
IV--455
(48%)
-Positive
Vilella, 2007
Spain PO  18  (detail)  589
(31%)
IV--615
(48%)
-Negative
Walker, 2010
Overlaps with
Thomson, 2006 (Scotland I)
CL  6  (detail)  386
(-)
IV--458
(-)
-n.a.
Walker, 2010
Scotland (II) CL  5  (detail)  303
(-)
IV--307
(-)
-Negative
Walker, 2010
Germany CL  3  (detail)  396
(-)
M--397
(-)
-Negative
Williams, 2003
UK, Ireland CL  3  (detail)  709
(32%)
IV-45 + 12
(-)
710
(33%)
43 + 12
(-)
Positive
 African Descent
Lachman, 2006
USA CL  4  (detail)  141
(-)
M--142
(-)
-Positive
 Asian
Fukui, 2006
Japan CL  4  (detail)  349
(46%)
IV23.7 + 7.9
(-)
41.9 + 14.9
(-)
424
(49%)
38.3 + 8.9
(-)
Positive
Garcia-Barcelo, 2010
China CL  1  (detail)  270
(-)
IV--270
(-)
-Negative
Hong, 2004
China CL  1  (detail)  228
(48%)
IV-40.6 + 10.4
(-)
269
(54%)
40.8 + 11.4
(-)
Negative
Ikeda, 2008
Japan (I) CL  58  (detail)  1126
(44%)
IV-47 + 15.3
(-)
1022
(48%)
38.8 + 14.5
(-)
Positive
Ikeda, 2008
Japan (II) CL  3  (detail)  1262
(48%)
IV-49.1 + 14.5
(-)
1172
(51%)
41.7 + 14.3
(-)
Negative
Iwata, 2004
Overlap with Ikeda, 2008 CL  6  (detail)  607
(-)
IV--515
(-)
-Negative
Kim, 2006
Korea CL  5  (detail)  242
(48%)
IV-33.2 + 9.6
(-)
242
(48%)
33.5 + 8.9
(-)
Positive
Li, 2004
China CL  24  (detail)  298
(-)
M--336
(96%)
-Positive
Shiota, 2008
Japan CL  13  (detail)  416
(46%)
IV-45 + 14.7
(-)
520
(46%)
37.5 + 11.3
(-)
Negative
So, 2009
China CL,PO  5  (detail)  489
(-)
IV--519
(-)
-Positive
Tang, 2004
China CL  9  (detail)  540
(-)
IIIR--279
(-)
-Positive
Zhao, 2004
China CL  5  (detail)  369
(52%)
U-41.5 + 14.3
(-)
299
(51%)
31.2 + 9
(-)
Positive
 Other/Mixed
Crowley, 2008
USA CL  1  (detail)  738
(26%)
U--733
(33%)
-Negative
Hong, 2007
USA CL  2  (detail)  244
(-)
IV--186
(-)
-Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds    
Study Population # Polys # Families # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Duan, 2005
Overlaps with
Duan, 2005
 14  (detail)  97-U----Negative
Fallin, 2005
USA  12  (detail)  263274
(26%)
IV19.5 + 4.5
(-)
-548
(50%)
-Negative
Georgieva, 2008
Bulgaria  14  (detail)  655655
(52%)
IV-32.8 + 8.5
(-)
1310
(50%)
-Positive
Hall, 2004
South Africa  5  (detail)  169169
(-)
IV--338
(80%)
-Positive
Hall, 2004
USA  5  (detail)  210210
(-)
IV--420
(50%)
-Negative
Petryshen, 2005
Portugal, USA  44  (detail)  111111
(-)
U--222
(50%)
-Positive
Rosa, 2007
Spain  8  (detail)  151-IV----Trend
Shaikh, 2010
Overlaps with
Shaikh, 2010 (CC)
 3  (detail)   138
(40%)
IV-40.8 + 11.8
(21-65)
109
(53%)
45.9 + 12.8
(19-65)
Negative
Stefansson, 2002
Iceland  7  (detail)   476
(-)
RDC----Positive
Thiselton, 2004
Ireland  7  (detail)  270724
(-)
U----Negative
Turunen, 2007
Finland  13  (detail)  441865
(39%)
IV--999
(-)
-Negative
Voineskos, 2009
Canada  2  (detail)  120120
(-)
IV19.8
(-)
---Negative
Wessman, 2009
Re-analysis of Turunen, 2007  11  (detail)  292-IV----n.a.
 Asian
Hong, 2004
China  1  (detail)  236236
(43%)
U-30.4 + 8.2
(-)
457
(49%)
-Positive
Ikeda, 2008
Japan  3  (detail)  166166
(45%)
IV-30 + 8.3
(-)
332
(50%)
-Negative
Li, 2004
China  24  (detail)  322-M--644
(50%)
-Positive
Yang, 2003
China  3  (detail)  246246
(-)
U--494
(50%)
-Positive
Zhao, 2004
China  5  (detail)  352352
(47%)
IIIR-23.8 + 6.6
(-)
704
(50%)
-Positive
 Hispanic
Walss-Bass, 2006b
Costa Rica  6  (detail)  134134
(-)
M----Negative
 Other/Mixed
Addington, 2006
USA  56  (detail)  7878
(41%)
M-14 + 3
(-)
129
(-)
-Positive
Duan, 2005
USA  14  (detail)  136-U----Negative
Walss-Bass, 2006a
USA, Costa Rica  1  (detail)  142142
(-)
M--236
(-)
-Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine SZ diagnosis ->  "IIIR"(DSM-IIIR), "IV" (DSM-IV), "9" (ICD-9), "10" (ICD-10), "M" (Mixed), "RDC" (Research Diagnostic Criteria), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
SZGene Recent Updates
SZGene Stats
Studies: 1727
Genes: 1008
Polymorphisms: 8788
Meta-analyses: 287
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