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SZGene - Gene overview of all published SZ-association studies for NRG1

Gene:

NRG1 (GGF; HGL; HRG; NDF; ARIA; GGF2; HRG1; HRGA; SMDF)

View on AlzGene

Protein:

neuregulin 1 (glial growth factor; neu differentiation factor; sensory and motor neuron derived factor; heregulin, alpha (45kD, ERBB2 p185-activator))

Chromosome:

8 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 23 November 2010

1. Case-Control Studies (by ethnic group)
				SZ Cases				Normal Controls
Study	Population	Source	# Polys	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result	Comment
Caucasian
Alaerts, 2009	Sweden	CL	37 (detail)	486 (37%)	IV	248 + 73 (-)	531 + 151 (-)	514 (54%)	58 + 13 (-)	Positive
Bakker, 2004	Netherlands	CL	3 (detail)	282 (-)	IV	-	-	585 (-)	-	Positive
Benzel, 2007	UK	CL	94 (detail)	396 (28%)	U	-	44 + 14 (-)	1342 (46%)	-	Positive
Bramon, 2008	UK	CL	3 (detail)	64 (25%)	IV	-	36 + 10 (-)	35 (54%)	41 + 14.4 (-)	Negative
Corvin, 2004	Ireland	CL	20 (detail)	243 (-)	IV	-	-	222 (-)	-	Positive
Dutt, 2009	UK, Ireland	CL	3 (detail)	83 (-)	IV	-	-	57 (-)	-	Negative
Hall, 2007	Overlaps with Jonsson, 2009 (Sweden)	CL	1 (detail)	103 (38%)	M	-	42.4 + 11.5 (-)	89 (33%)	39.2 + 11.5 (-)	n.a.
Hanninen, 2007	Finland	CL	1 (detail)	113 (39%)	IV	23.7 + 6.1 (-)	39.7 + 12 (18-76)	393 (46%)	44.5 + 11.1 (19-65)	Positive
Ingason, 2006	Denmark	CL	5 (detail)	325 (-)	10	-	-	353 (-)	-	Negative
Jonsson, 2009	Denmark, Norway, Sweden	CL	12 (detail)	837 (42%)	M	26.5 (-)	45.7 (-)	1473 (42%)	44.1 (-)	Negative
Jungerius, 2007	Netherlands	CL	17 (detail)	310 (-)	IV	-	-	880 (-)	-	Negative
Kampman, 2004	Finland	CL	1 (detail)	94 (-)	IV	-	-	395 (46%)	44.5 + 11.1 (19-65)	Negative
Lachman, 2006	USA	CL	4 (detail)	177 (-)	M	-	-	164 (-)	-	Negative
Nicodemus, 2009	USA	CL	1 (detail)	296 (-)	IV	-	-	365 (-)	-	Positive
Pedrosa, 2009	USA	CL	1 (detail)	176 (31%)	M	-	42 + 10 (-)	175 (45%)	48 + 13 (-)	Positive
Petryshen, 2005	Portugal, USA	CL	44 (detail)	321 (-)	IV	-	-	242 (46%)	-	Positive
Rethelyi, 2009	Hungary	CL	4 (detail)	280 (54%)	IV	28.6 (-)	37.6 (-)	230 (57%)	39.9 (-)	Positive
Sanders, 2008	USA, Australia	CL	216 (detail)	1870 (31%)	IV	-	-	2002 (53%)	-	Negative
Shaikh, 2010	Overlaps with Dutt, 2009	CL	3 (detail)	70 (-)	IV	-	-	204 (63%)	40.1 + 13.2 (18-65)	Negative
Squassina, 2010	Italy	CL	5 (detail)	171 (30%)	IV	-	36.7 + 9.7 (-)	349 (36%)	38.6 + 10.1 (-)	Negative
Stefansson, 2002	Iceland	CL	7 (detail)	478 (-)	RDC	-	-	394 (-)	-	Positive
Stefansson, 2003	UK (Scotland)	PO	7 (detail)	609 (-)	IIIR	-	-	618 (-)	-	Positive
Thomson, 2006	UK (Scotland)	CL	38 (detail)	386 (28%)	IV	-	-	455 (48%)	-	Positive
Vilella, 2007	Spain	PO	18 (detail)	589 (31%)	IV	-	-	615 (48%)	-	Negative
Walker, 2010	Overlaps with Thomson, 2006 (Scotland I)	CL	6 (detail)	386 (-)	IV	-	-	458 (-)	-	n.a.
Walker, 2010	Scotland (II)	CL	5 (detail)	303 (-)	IV	-	-	307 (-)	-	Negative
Walker, 2010	Germany	CL	3 (detail)	396 (-)	M	-	-	397 (-)	-	Negative
Williams, 2003	UK, Ireland	CL	3 (detail)	709 (32%)	IV	-	45 + 12 (-)	710 (33%)	43 + 12 (-)	Positive
African Descent
Lachman, 2006	USA	CL	4 (detail)	141 (-)	M	-	-	142 (-)	-	Positive
Asian
Fukui, 2006	Japan	CL	4 (detail)	349 (46%)	IV	23.7 + 7.9 (-)	41.9 + 14.9 (-)	424 (49%)	38.3 + 8.9 (-)	Positive
Garcia-Barcelo, 2010	China	CL	1 (detail)	270 (-)	IV	-	-	270 (-)	-	Negative
Hong, 2004	China	CL	1 (detail)	228 (48%)	IV	-	40.6 + 10.4 (-)	269 (54%)	40.8 + 11.4 (-)	Negative
Ikeda, 2008	Japan (I)	CL	58 (detail)	1126 (44%)	IV	-	47 + 15.3 (-)	1022 (48%)	38.8 + 14.5 (-)	Positive
Ikeda, 2008	Japan (II)	CL	3 (detail)	1262 (48%)	IV	-	49.1 + 14.5 (-)	1172 (51%)	41.7 + 14.3 (-)	Negative
Iwata, 2004	Overlap with Ikeda, 2008	CL	6 (detail)	607 (-)	IV	-	-	515 (-)	-	Negative
Kim, 2006	Korea	CL	5 (detail)	242 (48%)	IV	-	33.2 + 9.6 (-)	242 (48%)	33.5 + 8.9 (-)	Positive
Li, 2004	China	CL	24 (detail)	298 (-)	M	-	-	336 (96%)	-	Positive
Shiota, 2008	Japan	CL	13 (detail)	416 (46%)	IV	-	45 + 14.7 (-)	520 (46%)	37.5 + 11.3 (-)	Negative
So, 2009	China	CL,PO	5 (detail)	489 (-)	IV	-	-	519 (-)	-	Positive
Tang, 2004	China	CL	9 (detail)	540 (-)	IIIR	-	-	279 (-)	-	Positive
Zhao, 2004	China	CL	5 (detail)	369 (52%)	U	-	41.5 + 14.3 (-)	299 (51%)	31.2 + 9 (-)	Positive
Other/Mixed
Crowley, 2008	USA	CL	1 (detail)	738 (26%)	U	-	-	733 (33%)	-	Negative
Hong, 2007	USA	CL	2 (detail)	244 (-)	IV	-	-	186 (-)	-	Negative

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

2. Family-Based Studies (by ethnic group)
				Affecteds				Unaffecteds
Study	Population	# Polys	# Families	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result	Comment
Caucasian
Duan, 2005	Overlaps with Duan, 2005	14 (detail)	97	-	U	-	-	-	-	Negative
Fallin, 2005	USA	12 (detail)	263	274 (26%)	IV	19.5 + 4.5 (-)	-	548 (50%)	-	Negative
Georgieva, 2008	Bulgaria	14 (detail)	655	655 (52%)	IV	-	32.8 + 8.5 (-)	1310 (50%)	-	Positive
Hall, 2004	South Africa	5 (detail)	169	169 (-)	IV	-	-	338 (80%)	-	Positive
Hall, 2004	USA	5 (detail)	210	210 (-)	IV	-	-	420 (50%)	-	Negative
Petryshen, 2005	Portugal, USA	44 (detail)	111	111 (-)	U	-	-	222 (50%)	-	Positive
Rosa, 2007	Spain	8 (detail)	151	-	IV	-	-	-	-	Trend
Shaikh, 2010	Overlaps with Shaikh, 2010 (CC)	3 (detail)		138 (40%)	IV	-	40.8 + 11.8 (21-65)	109 (53%)	45.9 + 12.8 (19-65)	Negative
Stefansson, 2002	Iceland	7 (detail)		476 (-)	RDC	-	-	-	-	Positive
Thiselton, 2004	Ireland	7 (detail)	270	724 (-)	U	-	-	-	-	Negative
Turunen, 2007	Finland	13 (detail)	441	865 (39%)	IV	-	-	999 (-)	-	Negative
Voineskos, 2009	Canada	2 (detail)	120	120 (-)	IV	19.8 (-)	-	-	-	Negative
Wessman, 2009	Re-analysis of Turunen, 2007	11 (detail)	292	-	IV	-	-	-	-	n.a.
Asian
Hong, 2004	China	1 (detail)	236	236 (43%)	U	-	30.4 + 8.2 (-)	457 (49%)	-	Positive
Ikeda, 2008	Japan	3 (detail)	166	166 (45%)	IV	-	30 + 8.3 (-)	332 (50%)	-	Negative
Li, 2004	China	24 (detail)	322	-	M	-	-	644 (50%)	-	Positive
Yang, 2003	China	3 (detail)	246	246 (-)	U	-	-	494 (50%)	-	Positive
Zhao, 2004	China	5 (detail)	352	352 (47%)	IIIR	-	23.8 + 6.6 (-)	704 (50%)	-	Positive
Hispanic
Walss-Bass, 2006b	Costa Rica	6 (detail)	134	134 (-)	M	-	-	-	-	Negative
Other/Mixed
Addington, 2006	USA	56 (detail)	78	78 (41%)	M	-	14 + 3 (-)	129 (-)	-	Positive
Duan, 2005	USA	14 (detail)	136	-	U	-	-	-	-	Negative
Walss-Bass, 2006a	USA, Costa Rica	1 (detail)	142	142 (-)	M	-	-	236 (-)	-	Positive

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine SZ diagnosis -> "IIIR"(DSM-IIIR), "IV" (DSM-IV), "9" (ICD-9), "10" (ICD-10), "M" (Mixed), "RDC" (Research Diagnostic Criteria), "U" (Unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.


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